Daidzin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.217429
TRIO trio Rho guanine nucleotide exchange factor 0.111317
B2M beta-2-microglobulin 0.0873916
PTMA prothymosin, alpha 0.0841698
SLC35F3 solute carrier family 35, member F3 0.0744556
MEF2A myocyte enhancer factor 2A 0.0737413
PODXL podocalyxin-like 0.0704683
BHLHE40 basic helix-loop-helix family, member e40 0.067974
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0601628
KRT17 keratin 17, type I 0.0581524
OGA O-GlcNAcase 0.057833
AHNAK AHNAK nucleoprotein 0.0577089
EZR ezrin 0.0570106
PDE4D phosphodiesterase 4D, cAMP-specific 0.0561949
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0550685
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0546154
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0528086
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0519683
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0518366
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0516249
ITGA6 integrin, alpha 6 0.0495643
EFHD2 EF-hand domain family, member D2 0.0494245
VCL vinculin 0.0486486
NCOR2 nuclear receptor corepressor 2 0.048563
PRELID2 PRELI domain containing 2 0.0482592
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0437754
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0434311
SH3PXD2A SH3 and PX domains 2A 0.0429395
VIM vimentin 0.0426577
RPL35A ribosomal protein L35a 0.041739
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0413769
IFITM1 interferon induced transmembrane protein 1 0.040538
RPS19 ribosomal protein S19 0.0403252
ESYT2 extended synaptotagmin-like protein 2 0.0391105
YBX1 Y box binding protein 1 0.0376144
SLK STE20-like kinase 0.0372425
ADAM10 ADAM metallopeptidase domain 10 0.0370104
CALR calreticulin 0.0367867
GRB10 growth factor receptor-bound protein 10 0.0364678
AKAP13 A kinase (PRKA) anchor protein 13 0.0361111
TNIP1 TNFAIP3 interacting protein 1 0.0352798
PSD3 pleckstrin and Sec7 domain containing 3 0.0347573
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0345604
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0340707
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.034024
DST dystonin 0.0337608
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0332376
DSPP dentin sialophosphoprotein 0.0332199
ISG15 ISG15 ubiquitin-like modifier 0.0331815
LIMA1 LIM domain and actin binding 1 0.0321685
RPS8 ribosomal protein S8 0.0320397
SDC4 syndecan 4 0.0317375
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0311547
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0311252
BLCAP bladder cancer associated protein 0.030705
MYH9 myosin, heavy chain 9, non-muscle 0.03032
AKAP12 A kinase (PRKA) anchor protein 12 0.0300459
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0299911
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0298379
IFI44 interferon-induced protein 44 0.0292937
TPM3 tropomyosin 3 0.0286771
MEGF6 multiple EGF-like-domains 6 0.028488
IFI6 interferon, alpha-inducible protein 6 0.0271948
FNIP1 folliculin interacting protein 1 0.0271778
KMT2C lysine (K)-specific methyltransferase 2C 0.0266004
CD99 CD99 molecule 0.026181
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0260933
EEF1G eukaryotic translation elongation factor 1 gamma 0.0260715
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.026017
RPL37A ribosomal protein L37a 0.025873
TSC22D1 TSC22 domain family, member 1 0.0258381
DOCK5 dedicator of cytokinesis 5 0.0257341
EIF4B eukaryotic translation initiation factor 4B 0.0256826
MT2A metallothionein 2A 0.0254502
ARRDC3 arrestin domain containing 3 0.0253599
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0250497
FAM13A family with sequence similarity 13, member A 0.0249951
SOD2 superoxide dismutase 2, mitochondrial 0.0246824
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0240386
HLA-A major histocompatibility complex, class I, A 0.0239716
FNBP1L formin binding protein 1-like 0.0238881
WSB1 WD repeat and SOCS box containing 1 0.0237821
RIGI RNA sensor RIG-I 0.0235793
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0235364
MYO10 myosin X 0.0235245
NFE2L1 nuclear factor, erythroid 2-like 1 0.0231185
RPS6 ribosomal protein S6 0.0230928
MAML2 mastermind-like 2 (Drosophila) 0.0229338
TPT1 tumor protein, translationally-controlled 1 0.0228479
RPLP2 ribosomal protein, large, P2 0.0228091
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0227706
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0226237
SPATS2 spermatogenesis associated, serine-rich 2 0.0226008
RASAL2 RAS protein activator like 2 0.0224925
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0223737
TMED9 transmembrane emp24 protein transport domain containing 9 0.0222694
PDIA6 protein disulfide isomerase family A, member 6 0.0222581
EHF ets homologous factor 0.022036
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0219804
RICTOR RPTOR independent companion of MTOR, complex 2 0.0219735

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.205607
MYOF myoferlin -0.13534
LOC112694756 uncharaterized LOC112694756 -0.108129
IGF2 insulin-like growth factor 2 -0.10252
MTSS1 metastasis suppressor 1 -0.0915764
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0901842
OSMR oncostatin M receptor -0.0802768
MBNL1 muscleblind-like splicing regulator 1 -0.0778304
CAV1 caveolin 1, caveolae protein, 22kDa -0.0758174
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0729101
RPS2 ribosomal protein S2 -0.07161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0674333
CANX calnexin -0.063239
POTEF POTE ankyrin domain family, member F -0.0612736
FOXP1 forkhead box P1 -0.0586388
DSTN destrin (actin depolymerizing factor) -0.0579176
CD44 CD44 molecule (Indian blood group) -0.057016
STC1 stanniocalcin 1 -0.0559883
SMAD3 SMAD family member 3 -0.0527427
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0490766
IARS1 isoleucyl-tRNA synthetase 1 -0.048177
STAU1 staufen double-stranded RNA binding protein 1 -0.047853
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0464166
PTK2 protein tyrosine kinase 2 -0.0460324
ARF1 ADP-ribosylation factor 1 -0.0454624
NAMPT nicotinamide phosphoribosyltransferase -0.0442451
LAMA5 laminin, alpha 5 -0.0442022
LMO7 LIM domain 7 -0.0429672
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0415135
KMT2E lysine (K)-specific methyltransferase 2E -0.0413514
RAI14 retinoic acid induced 14 -0.0411813
KTN1 kinectin 1 (kinesin receptor) -0.0403411
RIN2 Ras and Rab interactor 2 -0.0401356
CDK6 cyclin-dependent kinase 6 -0.0399898
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0395862
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0392725
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0389272
COG5 component of oligomeric golgi complex 5 -0.0387304
RBM39 RNA binding motif protein 39 -0.0383091
CDC42 cell division cycle 42 -0.0380387
RPS24 ribosomal protein S24 -0.0378143
ANKRD28 ankyrin repeat domain 28 -0.0375031
NIPBL Nipped-B homolog (Drosophila) -0.0371248
FN1 fibronectin 1 -0.0369594
HSPG2 heparan sulfate proteoglycan 2 -0.036927
LMAN1 lectin, mannose-binding, 1 -0.0364699
CLTC clathrin, heavy chain (Hc) -0.0362228
CDK13 cyclin-dependent kinase 13 -0.0361924
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0361573
NDE1 nudE neurodevelopment protein 1 -0.0361147
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.035976
SULF2 sulfatase 2 -0.0359519
TOP1 topoisomerase (DNA) I -0.0359204
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0356917
TXNRD1 thioredoxin reductase 1 -0.0356657
ANKRD17 ankyrin repeat domain 17 -0.0351206
LDHA lactate dehydrogenase A -0.0348868
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0345224
HM13 histocompatibility (minor) 13 -0.0339878
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0338555
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0336841
TRAM1 translocation associated membrane protein 1 -0.0333483
CLINT1 clathrin interactor 1 -0.0333272
TKT transketolase -0.0330312
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0326564
MORF4L2 mortality factor 4 like 2 -0.0326314
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0323784
MBNL2 muscleblind-like splicing regulator 2 -0.0312536
RAB22A RAB22A, member RAS oncogene family -0.0312223
KCTD12 potassium channel tetramerization domain containing 12 -0.0310753
ANKHD1 ankyrin repeat and KH domain containing 1 -0.030878
NUP58 nucleoporin 58 -0.0308054
NAP1L1 nucleosome assembly protein 1-like 1 -0.0307489
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0307359
CAPN2 calpain 2, (m/II) large subunit -0.0305149
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0302693
RAB7A RAB7A, member RAS oncogene family -0.0299159
HMGA1 high mobility group AT-hook 1 -0.0297679
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0297471
RSRP1 arginine/serine-rich protein 1 -0.0295365
IPO7 importin 7 -0.0294129
MATR3 matrin 3 -0.0293824
ADNP activity-dependent neuroprotector homeobox -0.0293687
ITCH itchy E3 ubiquitin protein ligase -0.0290514
ARHGAP29 Rho GTPase activating protein 29 -0.0289887
DOCK9 dedicator of cytokinesis 9 -0.0289392
HLA-E major histocompatibility complex, class I, E -0.0289375
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0288431
VDAC1 voltage-dependent anion channel 1 -0.028554
BZW2 basic leucine zipper and W2 domains 2 -0.028132
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0281108
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0278003
PIBF1 progesterone immunomodulatory binding factor 1 -0.0277095
RPL39 ribosomal protein L39 -0.0273317
TMSB4X thymosin beta 4, X-linked -0.0272716
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0271872
CUL4B cullin 4B -0.0269696
NTSR1 neurotensin receptor 1 (high affinity) -0.0267238
TARS1 threonyl-tRNA synthetase 1 -0.0264918
CKAP2 cytoskeleton associated protein 2 -0.0264777