Daidzin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.166333
NDRG1 N-myc downstream regulated 1 0.157202
PTMA prothymosin, alpha 0.135026
FAM13A family with sequence similarity 13, member A 0.119548
RPS6 ribosomal protein S6 0.11481
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.105619
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0980412
PRELID2 PRELI domain containing 2 0.0932035
EZR ezrin 0.0901567
TXNIP thioredoxin interacting protein 0.0878842
DSPP dentin sialophosphoprotein 0.0773904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0729372
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0696809
NPSR1 neuropeptide S receptor 1 0.0680413
KRT18 keratin 18, type I 0.0665583
ITGA6 integrin, alpha 6 0.0629969
CCNY cyclin Y 0.0610676
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0597097
ESYT2 extended synaptotagmin-like protein 2 0.0596325
CENPF centromere protein F, 350/400kDa 0.0592029
RPS12 ribosomal protein S12 0.0591682
GOLGA4 golgin A4 0.057493
TPM3 tropomyosin 3 0.0520757
RPS2 ribosomal protein S2 0.0512337
RPL37A ribosomal protein L37a 0.0484135
CEMIP cell migration inducing protein, hyaluronan binding 0.0478396
RPS8 ribosomal protein S8 0.0467267
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0438868
FLNB filamin B, beta 0.0422302
UBA6 ubiquitin-like modifier activating enzyme 6 0.0414569
EREG epiregulin 0.0410458
ZNF292 zinc finger protein 292 0.040635
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0398655
PTPRR protein tyrosine phosphatase, receptor type, R 0.0396568
ERRFI1 ERBB receptor feedback inhibitor 1 0.0382757
SLK STE20-like kinase 0.0375491
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0374273
MXI1 MAX interactor 1, dimerization protein 0.0370604
ITPRID2 ITPR interacting domain containing 2 0.0364299
ASPH aspartate beta-hydroxylase 0.0362218
DDIT4 DNA-damage-inducible transcript 4 0.0347916
TNS4 tensin 4 0.0340021
EHF ets homologous factor 0.0335258
SBF2 SET binding factor 2 0.0334596
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0328059
GOLGB1 golgin B1 0.0327364
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0324543
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0318573
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0313388
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0311458
TMF1 TATA element modulatory factor 1 0.0310903
ANXA1 annexin A1 0.0310447
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0306198
RPL11 ribosomal protein L11 0.0305858
TMSB4X thymosin beta 4, X-linked 0.0301454
FNIP1 folliculin interacting protein 1 0.0300321
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0298903
HSPA8 heat shock 70kDa protein 8 0.0295668
RPS19 ribosomal protein S19 0.029443
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0293629
RPS3 ribosomal protein S3 0.0286327
PLAUR plasminogen activator, urokinase receptor 0.0282512
UGCG UDP-glucose ceramide glucosyltransferase 0.0275306
RNF217 ring finger protein 217 0.0268818
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0268316
CD46 CD46 molecule, complement regulatory protein 0.0266903
KAT6B K(lysine) acetyltransferase 6B 0.0264522
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0261903
TRIO trio Rho guanine nucleotide exchange factor 0.0259068
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0255669
CALB1 calbindin 1, 28kDa 0.0253715
EIF4B eukaryotic translation initiation factor 4B 0.0252306
RPL35A ribosomal protein L35a 0.0246776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0244874
DENND4C DENN/MADD domain containing 4C 0.0243952
RPL26 ribosomal protein L26 0.0242064
CDK19 cyclin-dependent kinase 19 0.0241802
FOSL1 FOS-like antigen 1 0.0241435
BCLAF1 BCL2-associated transcription factor 1 0.024105
PRRC2C proline-rich coiled-coil 2C 0.0240889
ARHGAP26 Rho GTPase activating protein 26 0.0239543
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0236544
KLF3 Kruppel-like factor 3 (basic) 0.0234936
OGA O-GlcNAcase 0.0233282
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0233129
KTN1 kinectin 1 (kinesin receptor) 0.0232875
INSIG1 insulin induced gene 1 0.0229117
KDM6A lysine (K)-specific demethylase 6A 0.0227096
NAMPT nicotinamide phosphoribosyltransferase 0.0225815
FNBP1L formin binding protein 1-like 0.0224421
EPHA2 EPH receptor A2 0.0224248
KIF5B kinesin family member 5B 0.0223489
MAML2 mastermind-like 2 (Drosophila) 0.0221191
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0219825
KMT2E lysine (K)-specific methyltransferase 2E 0.0219731
TBC1D5 TBC1 domain family, member 5 0.0219283
MUC13 mucin 13, cell surface associated 0.0218295
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0217706
MKI67 marker of proliferation Ki-67 0.0216007
RLF rearranged L-myc fusion 0.0215372

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.2503
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192195
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.138332
MYO1E myosin IE -0.124811
TMSB10 thymosin beta 10 -0.11855
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.110669
LOC112694756 uncharaterized LOC112694756 -0.0797503
UBC ubiquitin C -0.0603594
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0600285
FTL ferritin, light polypeptide -0.0577802
EXT1 exostosin glycosyltransferase 1 -0.0553993
GMDS GDP-mannose 4,6-dehydratase -0.0551472
AHNAK AHNAK nucleoprotein -0.0534185
CANX calnexin -0.052931
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0518769
CCND1 cyclin D1 -0.0490321
MUC6 mucin 6, oligomeric mucus/gel-forming -0.048587
ACTN4 actinin, alpha 4 -0.0478604
VCL vinculin -0.0468708
PKM pyruvate kinase, muscle -0.0441469
RAB10 RAB10, member RAS oncogene family -0.043042
PIGR polymeric immunoglobulin receptor -0.0427054
PDIA3 protein disulfide isomerase family A, member 3 -0.0422002
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0413773
LDHA lactate dehydrogenase A -0.0410114
ABLIM1 actin binding LIM protein 1 -0.040293
RPS24 ribosomal protein S24 -0.0386714
H1-0 H1.0 linker histone -0.0379426
HDLBP high density lipoprotein binding protein -0.0377697
SOX9 SRY (sex determining region Y)-box 9 -0.0365126
EEF2 eukaryotic translation elongation factor 2 -0.0364901
ARF1 ADP-ribosylation factor 1 -0.036365
POTEF POTE ankyrin domain family, member F -0.0361231
ONECUT3 one cut homeobox 3 -0.0349815
LMO7 LIM domain 7 -0.0347468
S100A6 S100 calcium binding protein A6 -0.0345993
IARS1 isoleucyl-tRNA synthetase 1 -0.0340669
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0340099
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0336527
ANKRD17 ankyrin repeat domain 17 -0.0335295
RPLP1 ribosomal protein, large, P1 -0.0333289
CD44 CD44 molecule (Indian blood group) -0.0330648
POF1B premature ovarian failure, 1B -0.0330281
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0329912
PDIA4 protein disulfide isomerase family A, member 4 -0.0325045
MUC17 mucin 17, cell surface associated -0.0317634
FTH1 ferritin, heavy polypeptide 1 -0.0316213
ACTG1 actin gamma 1 -0.0315484
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0303042
TJP1 tight junction protein 1 -0.0298515
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0296981
NCEH1 neutral cholesterol ester hydrolase 1 -0.0289295
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0279844
AGR2 anterior gradient 2 -0.0278756
VDAC1 voltage-dependent anion channel 1 -0.0271717
EGR1 early growth response 1 -0.0264664
RPS27A ribosomal protein S27a -0.0259852
MBNL1 muscleblind-like splicing regulator 1 -0.0254744
LOC102724023 ES1 protein homolog, mitochondrial -0.0251622
IER3 immediate early response 3 -0.024409
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0243934
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0239674
SMAD2 SMAD family member 2 -0.0238936
RBM25 RNA binding motif protein 25 -0.023257
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232335
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0226283
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0225995
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0222936
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0222652
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0221367
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0220992
NPR2 natriuretic peptide receptor 2 -0.0220005
AGO2 argonaute RISC catalytic component 2 -0.0219581
RAB7A RAB7A, member RAS oncogene family -0.0216208
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0214945
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0210459
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0209271
RPL4 ribosomal protein L4 -0.0209134
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0209042
PTPRK protein tyrosine phosphatase, receptor type, K -0.0207484
MTAP methylthioadenosine phosphorylase -0.0207255
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0205112
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.020445
ABR active BCR-related -0.0204064
PTPRG protein tyrosine phosphatase, receptor type, G -0.0203466
PALLD palladin, cytoskeletal associated protein -0.0202924
PCBP2 poly(rC) binding protein 2 -0.0199006
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.019806
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0195473
FOXO1 forkhead box O1 -0.019373
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0191863
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0190379
MYH14 myosin, heavy chain 14, non-muscle -0.0189804
FNDC3A fibronectin type III domain containing 3A -0.0189089
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0188877
ARHGAP42 Rho GTPase activating protein 42 -0.0188054
HMGB1 high mobility group box 1 -0.0186987
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0186805
RAD21 RAD21 homolog (S. pombe) -0.018676
CCNI cyclin I -0.0185331