Daidzin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.121248
DLG1 discs, large homolog 1 (Drosophila) 0.112566
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.111341
PTMA prothymosin, alpha 0.103947
DST dystonin 0.0955376
ANKRD11 ankyrin repeat domain 11 0.07265
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.068998
EXOC4 exocyst complex component 4 0.0670364
RAD51B RAD51 paralog B 0.0669721
RAI1 retinoic acid induced 1 0.0643656
CENPF centromere protein F, 350/400kDa 0.0634729
DOCK11 dedicator of cytokinesis 11 0.0611652
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0601379
GOLGA4 golgin A4 0.0579335
PRELID2 PRELI domain containing 2 0.0576225
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0569334
EZR ezrin 0.0546731
EHBP1 EH domain binding protein 1 0.0545563
FNIP1 folliculin interacting protein 1 0.0537306
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0513131
TBC1D5 TBC1 domain family, member 5 0.0500192
EEF2 eukaryotic translation elongation factor 2 0.0494951
FMNL2 formin-like 2 0.0483309
SLK STE20-like kinase 0.047993
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0479414
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0458123
SBF2 SET binding factor 2 0.0446789
EFNA5 ephrin-A5 0.0443254
SMYD3 SET and MYND domain containing 3 0.0431444
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0421884
RPL23 ribosomal protein L23 0.041806
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0416759
ANKRD12 ankyrin repeat domain 12 0.0412157
ANKRD36 ankyrin repeat domain 36 0.0408191
FUS FUS RNA binding protein 0.0405864
AHNAK2 AHNAK nucleoprotein 2 0.0405692
BABAM2 BRISC and BRCA1 A complex member 2 0.0404595
YEATS2 YEATS domain containing 2 0.0396558
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0387324
TSC22D1 TSC22 domain family, member 1 0.0386698
MBNL2 muscleblind-like splicing regulator 2 0.0385845
ZNF292 zinc finger protein 292 0.0377033
TRA2B transformer 2 beta homolog (Drosophila) 0.0374572
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0362921
MT2A metallothionein 2A 0.0361748
PTK2 protein tyrosine kinase 2 0.0356477
RTTN rotatin 0.0355215
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0354052
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0353512
CDK19 cyclin-dependent kinase 19 0.0352285
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0351633
UBAP2L ubiquitin associated protein 2-like 0.0346476
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0344467
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0341979
FLNB filamin B, beta 0.0339599
ESYT2 extended synaptotagmin-like protein 2 0.033832
MKI67 marker of proliferation Ki-67 0.033568
CFDP1 craniofacial development protein 1 0.0335297
MINK1 misshapen-like kinase 1 0.0334228
CHD9 chromodomain helicase DNA binding protein 9 0.0332458
TRERF1 transcriptional regulating factor 1 0.0324872
OGA O-GlcNAcase 0.0324032
VEGFA vascular endothelial growth factor A 0.0322769
KMT2C lysine (K)-specific methyltransferase 2C 0.0318078
DENND1A DENN/MADD domain containing 1A 0.0317958
PTBP2 polypyrimidine tract binding protein 2 0.0315083
AKAP9 A kinase (PRKA) anchor protein 9 0.0313286
MAP4 microtubule-associated protein 4 0.0306993
TTC28 tetratricopeptide repeat domain 28 0.0305883
GYS1 glycogen synthase 1 (muscle) 0.0302963
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0302248
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0300393
THOC2 THO complex 2 0.0297765
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0293072
ZNF148 zinc finger protein 148 0.0292089
LPP LIM domain containing preferred translocation partner in lipoma 0.0290912
PTPRF protein tyrosine phosphatase, receptor type, F 0.0289736
CD109 CD109 molecule 0.0286148
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.028375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0283332
NDRG1 N-myc downstream regulated 1 0.0281829
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0280082
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0279891
GIGYF2 GRB10 interacting GYF protein 2 0.0277683
EIF4H eukaryotic translation initiation factor 4H 0.0277391
MBD5 methyl-CpG binding domain protein 5 0.0276675
ANXA1 annexin A1 0.0275522
APP amyloid beta (A4) precursor protein 0.0275371
RPL7A ribosomal protein L7a 0.0272636
SINHCAF SIN3-HDAC complex associated factor 0.0272564
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0268644
EIF4B eukaryotic translation initiation factor 4B 0.0266063
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0265357
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.026308
PDE8A phosphodiesterase 8A 0.0260888
ANXA2 annexin A2 0.0260572
PHF21A PHD finger protein 21A 0.025906
N4BP2L2 NEDD4 binding protein 2-like 2 0.025748
MOK MOK protein kinase 0.0255511
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0255124

decreased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 -0.218414
TP63 tumor protein p63 -0.205662
TXNRD1 thioredoxin reductase 1 -0.118708
SPAG9 sperm associated antigen 9 -0.114085
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109641
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0990621
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0963389
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0942149
LOC112694756 uncharaterized LOC112694756 -0.0908973
WWTR1 WW domain containing transcription regulator 1 -0.0898889
EGR1 early growth response 1 -0.08852
KTN1 kinectin 1 (kinesin receptor) -0.0802368
POTEF POTE ankyrin domain family, member F -0.0795814
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0774371
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0747184
CANX calnexin -0.0734799
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0703197
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.069675
TM4SF1 transmembrane 4 L six family member 1 -0.0643377
KMT2E lysine (K)-specific methyltransferase 2E -0.0628953
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0616236
ZEB1 zinc finger E-box binding homeobox 1 -0.057279
TMEM41B transmembrane protein 41B -0.0565873
USP34 ubiquitin specific peptidase 34 -0.0561935
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0548451
CAPRIN2 caprin family member 2 -0.0530902
FBXO11 F-box protein 11 -0.052717
USP12 ubiquitin specific peptidase 12 -0.0501355
RPS2 ribosomal protein S2 -0.0497952
TSC22D2 TSC22 domain family, member 2 -0.0491802
CDCP1 CUB domain containing protein 1 -0.0490525
EREG epiregulin -0.0484744
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0479862
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0477321
SP100 SP100 nuclear antigen -0.0470909
ARID4B AT rich interactive domain 4B (RBP1-like) -0.046003
HMGA1 high mobility group AT-hook 1 -0.045533
TPT1 tumor protein, translationally-controlled 1 -0.0450398
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.044
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0439665
VMP1 vacuole membrane protein 1 -0.0436036
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0429263
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0428073
ZFAND3 zinc finger, AN1-type domain 3 -0.0427403
ARHGAP5 Rho GTPase activating protein 5 -0.0421347
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0421054
PCBP2 poly(rC) binding protein 2 -0.0420441
NUP58 nucleoporin 58 -0.0419256
SOD2 superoxide dismutase 2, mitochondrial -0.0418318
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0417717
TGM2 transglutaminase 2 -0.0410356
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0402338
IPO7 importin 7 -0.0399818
CSNK1A1 casein kinase 1, alpha 1 -0.0388702
RCOR1 REST corepressor 1 -0.0386868
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0386608
IFIH1 interferon induced with helicase C domain 1 -0.0371853
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0371832
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0363395
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0361984
ATP13A3 ATPase type 13A3 -0.0361706
RIGI RNA sensor RIG-I -0.0359802
BIRC3 baculoviral IAP repeat containing 3 -0.0357244
PYGL phosphorylase, glycogen, liver -0.0357125
VDAC1 voltage-dependent anion channel 1 -0.0357122
CLTC clathrin, heavy chain (Hc) -0.0348942
CXCL8 chemokine (C-X-C motif) ligand 8 -0.034827
WARS1 tryptophanyl-tRNA synthetase 1 -0.0340524
SPRY4 sprouty homolog 4 (Drosophila) -0.033868
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0335796
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0333017
PLSCR1 phospholipid scramblase 1 -0.0332172
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0332043
RPL12 ribosomal protein L12 -0.0329648
NEK10 NIMA-related kinase 10 -0.0325143
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.032494
PDIA3 protein disulfide isomerase family A, member 3 -0.0324731
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0324079
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0316968
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0314823
CMIP c-Maf inducing protein -0.031284
PAPOLA poly(A) polymerase alpha -0.0311751
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0310258
ECE1 endothelin converting enzyme 1 -0.0306924
HOMER1 homer scaffolding protein 1 -0.0305965
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.030514
SGK1 serum/glucocorticoid regulated kinase 1 -0.0303746
CLIP2 CAP-GLY domain containing linker protein 2 -0.0303306
KDM3A lysine (K)-specific demethylase 3A -0.0302748
DNER delta/notch-like EGF repeat containing -0.0298497
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0298049
STRN3 striatin, calmodulin binding protein 3 -0.0296663
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0294934
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0294402
RPL27A ribosomal protein L27a -0.0293091
CFLAR CASP8 and FADD-like apoptosis regulator -0.0290999
TAOK1 TAO kinase 1 -0.0290882
HLA-B major histocompatibility complex, class I, B -0.0289857
BICD1 bicaudal D homolog 1 (Drosophila) -0.0287091
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0284447