Daidzin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Daidzin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.181864
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.137901
TPM3 tropomyosin 3 0.0992831
RAD51B RAD51 paralog B 0.0963001
PTMA prothymosin, alpha 0.073421
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0725999
PABPC1 poly(A) binding protein, cytoplasmic 1 0.064662
RPS3 ribosomal protein S3 0.0573215
PRELID2 PRELI domain containing 2 0.0489273
MACF1 microtubule-actin crosslinking factor 1 0.0474495
RPL37A ribosomal protein L37a 0.0467722
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0465621
KRT18 keratin 18, type I 0.0460138
RPS12 ribosomal protein S12 0.0456534
HSPA8 heat shock 70kDa protein 8 0.0454531
AKAP12 A kinase (PRKA) anchor protein 12 0.045407
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0440336
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0412962
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0409602
RPS6 ribosomal protein S6 0.0391865
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0377801
WWOX WW domain containing oxidoreductase 0.0375019
ANKRD36 ankyrin repeat domain 36 0.0368707
EXOC4 exocyst complex component 4 0.036657
EIF4B eukaryotic translation initiation factor 4B 0.036654
ATXN1 ataxin 1 0.0360179
RPS2 ribosomal protein S2 0.0354211
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0350717
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0341271
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0341082
SET SET nuclear proto-oncogene 0.033556
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0330945
HDGF hepatoma-derived growth factor 0.0328436
RPS10 ribosomal protein S10 0.0328259
DST dystonin 0.0327749
MKI67 marker of proliferation Ki-67 0.0327409
RPS8 ribosomal protein S8 0.0319015
CENPF centromere protein F, 350/400kDa 0.0317478
PRKCE protein kinase C, epsilon 0.0314202
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0312314
TBC1D5 TBC1 domain family, member 5 0.0307116
BABAM2 BRISC and BRCA1 A complex member 2 0.030583
RPL11 ribosomal protein L11 0.030472
PDE4D phosphodiesterase 4D, cAMP-specific 0.0293113
MSH2 mutS homolog 2 0.0288424
CAMTA1 calmodulin binding transcription activator 1 0.0287997
PNN pinin, desmosome associated protein 0.0283597
RPL3 ribosomal protein L3 0.0277485
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272923
GIGYF2 GRB10 interacting GYF protein 2 0.0271317
RPS27 ribosomal protein S27 0.0268273
PHF21A PHD finger protein 21A 0.0268174
EEF1G eukaryotic translation elongation factor 1 gamma 0.0267452
LDHB lactate dehydrogenase B 0.0263644
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0262942
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262741
BCLAF1 BCL2-associated transcription factor 1 0.0262683
TMEM14B transmembrane protein 14B 0.0260081
RPS27A ribosomal protein S27a 0.0256821
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0253773
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0252935
TPI1 triosephosphate isomerase 1 0.025204
ANKRD36B ankyrin repeat domain 36B 0.0251575
RAB6A RAB6A, member RAS oncogene family 0.024453
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.0243848
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0242978
FUS FUS RNA binding protein 0.0238751
RPL26 ribosomal protein L26 0.0238415
CEP192 centrosomal protein 192kDa 0.023839
YBX1 Y box binding protein 1 0.0236321
RPS29 ribosomal protein S29 0.023595
TRIO trio Rho guanine nucleotide exchange factor 0.0234338
RPS7 ribosomal protein S7 0.0233988
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.02332
MXI1 MAX interactor 1, dimerization protein 0.0232005
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0231319
FAM168A family with sequence similarity 168, member A 0.0228222
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0227946
RPS18 ribosomal protein S18 0.0224957
RPL8 ribosomal protein L8 0.0223931
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0223392
CHD1L chromodomain helicase DNA binding protein 1-like 0.0222402
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0220369
RPL34 ribosomal protein L34 0.0219427
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0217361
SRRM1 serine/arginine repetitive matrix 1 0.0217199
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0215234
RPL7 ribosomal protein L7 0.0214572
CEP250 centrosomal protein 250kDa 0.0214509
CCNY cyclin Y 0.0214353
FAM13A family with sequence similarity 13, member A 0.0214037
NCKAP1 NCK-associated protein 1 0.0213869
PHF20 PHD finger protein 20 0.0211711
SPIRE1 spire-type actin nucleation factor 1 0.0211411
SPATS2 spermatogenesis associated, serine-rich 2 0.0211008
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0210298
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.020999
DSPP dentin sialophosphoprotein 0.0209008
EFNA5 ephrin-A5 0.0204622
BBX bobby sox homolog (Drosophila) 0.020443

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.12594
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118442
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11199
OSMR oncostatin M receptor -0.108648
RAB7A RAB7A, member RAS oncogene family -0.0875379
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0862366
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0840528
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0774119
VCL vinculin -0.0773264
NABP1 nucleic acid binding protein 1 -0.0756671
TMSB10 thymosin beta 10 -0.0688692
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0680244
CDK17 cyclin-dependent kinase 17 -0.0622912
ELL2 elongation factor, RNA polymerase II, 2 -0.0608928
YBX3 Y box binding protein 3 -0.0604738
LOC102724023 ES1 protein homolog, mitochondrial -0.0583601
MORF4L2 mortality factor 4 like 2 -0.0574002
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0573604
VIM vimentin -0.0571682
TXNRD1 thioredoxin reductase 1 -0.0564297
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0557994
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0549125
ACTG1 actin gamma 1 -0.0526363
MCL1 myeloid cell leukemia 1 -0.0518926
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0511232
TAS2R14 taste receptor, type 2, member 14 -0.0497341
FBXO11 F-box protein 11 -0.047703
WWTR1 WW domain containing transcription regulator 1 -0.0457983
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0449743
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0446698
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0443798
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0442646
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0438527
WNT2B wingless-type MMTV integration site family, member 2B -0.0431648
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0426827
POTEF POTE ankyrin domain family, member F -0.0411581
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0398805
E2F3 E2F transcription factor 3 -0.0395609
SLC38A2 solute carrier family 38, member 2 -0.0392149
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0389711
VDAC1 voltage-dependent anion channel 1 -0.0386597
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0384723
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0382214
USP34 ubiquitin specific peptidase 34 -0.0379337
ZNF644 zinc finger protein 644 -0.0371216
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0368758
ATF6 activating transcription factor 6 -0.0368638
ZNF207 zinc finger protein 207 -0.0364955
MED13 mediator complex subunit 13 -0.0361296
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0360432
PDE10A phosphodiesterase 10A -0.0359254
STC1 stanniocalcin 1 -0.0358689
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.035775
SETX senataxin -0.0354993
EXT1 exostosin glycosyltransferase 1 -0.0351474
SPAG9 sperm associated antigen 9 -0.0350695
RHEB Ras homolog enriched in brain -0.0346434
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0344333
TRIP12 thyroid hormone receptor interactor 12 -0.0339944
RAB1A RAB1A, member RAS oncogene family -0.0338086
BIRC6 baculoviral IAP repeat containing 6 -0.0336839
PLSCR1 phospholipid scramblase 1 -0.033257
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0327104
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0325676
RPS24 ribosomal protein S24 -0.0325488
IGF1R insulin-like growth factor 1 receptor -0.0325455
EML4 echinoderm microtubule associated protein like 4 -0.0324335
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0324295
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0324002
SNAP25 synaptosomal-associated protein, 25kDa -0.0321931
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0320283
CCND1 cyclin D1 -0.0317404
AGO3 argonaute RISC catalytic component 3 -0.0315484
RAD21 RAD21 homolog (S. pombe) -0.0315039
PDLIM5 PDZ and LIM domain 5 -0.0312395
LMAN1 lectin, mannose-binding, 1 -0.0311484
TPM4 tropomyosin 4 -0.0308551
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0308514
ATP13A3 ATPase type 13A3 -0.0307502
ACTN1 actinin, alpha 1 -0.0306795
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0305804
AHNAK AHNAK nucleoprotein -0.030241
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0299672
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0296397
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0295413
PYGL phosphorylase, glycogen, liver -0.0295082
SPDYA speedy/RINGO cell cycle regulator family member A -0.0292509
COPA coatomer protein complex, subunit alpha -0.0291205
KLF6 Kruppel-like factor 6 -0.0290229
HMGA2 high mobility group AT-hook 2 -0.0287817
NIPBL Nipped-B homolog (Drosophila) -0.0287452
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0287378
RPLP1 ribosomal protein, large, P1 -0.0287256
KLF7 Kruppel-like factor 7 (ubiquitous) -0.028681
PRH1 proline-rich protein HaeIII subfamily 1 -0.0284994
ATP11A ATPase, class VI, type 11A -0.0281367
RPL4 ribosomal protein L4 -0.0280564
KDM3A lysine (K)-specific demethylase 3A -0.0280339
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.027867
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.02785