Daidzin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Daidzin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.150854
AKAP12 A kinase (PRKA) anchor protein 12 0.134653
PDE4D phosphodiesterase 4D, cAMP-specific 0.133887
PGK1 phosphoglycerate kinase 1 0.12847
GPC6 glypican 6 0.120328
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.117258
USP34 ubiquitin specific peptidase 34 0.114741
NAMPT nicotinamide phosphoribosyltransferase 0.113586
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.102442
KMT2C lysine (K)-specific methyltransferase 2C 0.097228
SEPTIN9 septin 9 0.0964798
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0879431
PTK2 protein tyrosine kinase 2 0.0814103
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0780942
ZBTB20 zinc finger and BTB domain containing 20 0.0780863
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0777278
ERBIN erbb2 interacting protein 0.0775359
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0765508
SPAG9 sperm associated antigen 9 0.0760996
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0756888
SBF2 SET binding factor 2 0.0753968
KDM3A lysine (K)-specific demethylase 3A 0.0747942
KMT2E lysine (K)-specific methyltransferase 2E 0.0745518
UBA6 ubiquitin-like modifier activating enzyme 6 0.0735479
DST dystonin 0.0701517
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.069551
SFPQ splicing factor proline/glutamine-rich 0.0694003
SETD5 SET domain containing 5 0.0689152
FGFR2 fibroblast growth factor receptor 2 0.0670369
AHNAK AHNAK nucleoprotein 0.0661467
RUNX1 runt-related transcription factor 1 0.0641553
AKAP13 A kinase (PRKA) anchor protein 13 0.0641536
DENND1A DENN/MADD domain containing 1A 0.0631965
KTN1 kinectin 1 (kinesin receptor) 0.0629142
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0596059
TMCC1 transmembrane and coiled-coil domain family 1 0.0592146
DLG1 discs, large homolog 1 (Drosophila) 0.057858
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0576287
MBNL2 muscleblind-like splicing regulator 2 0.0574253
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0568492
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0562944
SQSTM1 sequestosome 1 0.0559248
GNPDA1 glucosamine-6-phosphate deaminase 1 0.054992
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0547123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0541477
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0533974
ATXN1 ataxin 1 0.0532815
INHBA inhibin, beta A 0.0514001
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0512431
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0503378
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0499883
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0498173
ZFAND3 zinc finger, AN1-type domain 3 0.0493887
PRELID2 PRELI domain containing 2 0.0487861
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0486722
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0482129
TMEM87A transmembrane protein 87A 0.0473875
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0469611
DSCAM Down syndrome cell adhesion molecule 0.0465197
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0454069
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0452832
DIAPH2 diaphanous-related formin 2 0.0443582
TOP1 topoisomerase (DNA) I 0.0437284
PICALM phosphatidylinositol binding clathrin assembly protein 0.0434797
STAG2 stromal antigen 2 0.0430872
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0422216
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0415281
OGA O-GlcNAcase 0.0398569
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0392595
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0390674
DPYD dihydropyrimidine dehydrogenase 0.0386231
TM9SF3 transmembrane 9 superfamily member 3 0.0385753
RSRC2 arginine/serine-rich coiled-coil 2 0.0376185
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0375979
ELL2 elongation factor, RNA polymerase II, 2 0.0375631
TMEM263 transmembrane protein 263 0.037336
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0366579
LOC102724023 ES1 protein homolog, mitochondrial 0.0366577
ESYT2 extended synaptotagmin-like protein 2 0.0359689
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0350405
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0349021
RSF1 remodeling and spacing factor 1 0.0347142
NDRG1 N-myc downstream regulated 1 0.0338806
MATR3 matrin 3 0.0338438
B2M beta-2-microglobulin 0.0333744
KLF7 Kruppel-like factor 7 (ubiquitous) 0.033236
RAD51B RAD51 paralog B 0.0330901
NALF1 NALCN channel auxiliary factor 1 0.0323117
FNIP1 folliculin interacting protein 1 0.0316541
MEF2A myocyte enhancer factor 2A 0.0306048
FMNL2 formin-like 2 0.0305842
EFNA5 ephrin-A5 0.0303888
N4BP2L2 NEDD4 binding protein 2-like 2 0.0302454
OXR1 oxidation resistance 1 0.0301461
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.029715
H3-3B H3.3 histone B 0.0295375
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0285324
PSD3 pleckstrin and Sec7 domain containing 3 0.0282142
ZEB1 zinc finger E-box binding homeobox 1 0.02812
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0277146

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.127276
FN1 fibronectin 1 -0.126598
RPLP1 ribosomal protein, large, P1 -0.114355
LRP1B low density lipoprotein receptor-related protein 1B -0.113814
LAMB3 laminin, beta 3 -0.109469
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.106159
RPS8 ribosomal protein S8 -0.101847
TMSB10 thymosin beta 10 -0.0991779
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0955423
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0954418
TPT1 tumor protein, translationally-controlled 1 -0.0953688
RPL34 ribosomal protein L34 -0.094387
PARD3 par-3 family cell polarity regulator -0.0896006
EXT1 exostosin glycosyltransferase 1 -0.0832611
EIF1 eukaryotic translation initiation factor 1 -0.082724
LMO7 LIM domain 7 -0.081626
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0810437
PRKCA protein kinase C, alpha -0.0796083
EGFR epidermal growth factor receptor -0.0780733
RPL12 ribosomal protein L12 -0.071578
IGF2 insulin-like growth factor 2 -0.070749
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0699419
ALCAM activated leukocyte cell adhesion molecule -0.069553
ENO1 enolase 1, (alpha) -0.069381
SRRM2 serine/arginine repetitive matrix 2 -0.0693654
RPLP2 ribosomal protein, large, P2 -0.0687173
MAML3 mastermind-like 3 (Drosophila) -0.0664726
RPL15 ribosomal protein L15 -0.0655179
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0650362
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0636528
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0636405
ACTG1 actin gamma 1 -0.0621684
MACF1 microtubule-actin crosslinking factor 1 -0.0612476
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0612427
PTMA prothymosin, alpha -0.0610851
RACK1 receptor for activated C kinase 1 -0.0610141
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0605661
SP100 SP100 nuclear antigen -0.0599274
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0590179
CEMIP cell migration inducing protein, hyaluronan binding -0.0570822
RPS13 ribosomal protein S13 -0.0565333
PDE10A phosphodiesterase 10A -0.0564339
HMGA2 high mobility group AT-hook 2 -0.0564304
VCL vinculin -0.0555879
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0554594
DOCK4 dedicator of cytokinesis 4 -0.0539299
PDLIM5 PDZ and LIM domain 5 -0.0536803
MYO1E myosin IE -0.0530786
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0526461
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0524696
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0509389
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0492659
RPS25 ribosomal protein S25 -0.0480666
RPLP0 ribosomal protein, large, P0 -0.04704
STC1 stanniocalcin 1 -0.046601
RPS27A ribosomal protein S27a -0.0462382
RPS19 ribosomal protein S19 -0.0454766
COL5A1 collagen, type V, alpha 1 -0.0447623
SLTM SAFB-like, transcription modulator -0.0446438
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0441064
TBC1D5 TBC1 domain family, member 5 -0.0427666
MYOF myoferlin -0.0425496
RPL11 ribosomal protein L11 -0.0422967
RPS16 ribosomal protein S16 -0.0422232
NIPBL Nipped-B homolog (Drosophila) -0.0399234
RPL26 ribosomal protein L26 -0.0393105
SPATA13 spermatogenesis associated 13 -0.0381021
NAV2 neuron navigator 2 -0.0380659
FNDC3A fibronectin type III domain containing 3A -0.0377038
LAMA4 laminin, alpha 4 -0.0364075
RPL37 ribosomal protein L37 -0.0360968
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0360095
BIRC6 baculoviral IAP repeat containing 6 -0.035542
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0353601
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0338298
FOXP1 forkhead box P1 -0.0326515
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0325018
WASF2 WAS protein family, member 2 -0.0323222
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0318191
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0317207
SMYD3 SET and MYND domain containing 3 -0.0315791
RPS6 ribosomal protein S6 -0.0312151
EGR1 early growth response 1 -0.0311652
TBC1D22A TBC1 domain family, member 22A -0.0308321
MYO5B myosin VB -0.0308013
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0305358
RAB2A RAB2A, member RAS oncogene family -0.0293292
ARHGAP26 Rho GTPase activating protein 26 -0.0284135
ANKRD12 ankyrin repeat domain 12 -0.0283506
GRAMD1B GRAM domain containing 1B -0.0281416
AFF4 AF4/FMR2 family, member 4 -0.0278501
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0276011
VIM vimentin -0.0263937
EEF2 eukaryotic translation elongation factor 2 -0.0256441
ARHGAP32 Rho GTPase activating protein 32 -0.0256112
NPEPPS aminopeptidase puromycin sensitive -0.0252721
AKAP9 A kinase (PRKA) anchor protein 9 -0.0248533
ANKRD11 ankyrin repeat domain 11 -0.0245511
NPC1 Niemann-Pick disease, type C1 -0.0240108
SNX9 sorting nexin 9 -0.023842