Daidzin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.22196
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.134464
NDRG1 N-myc downstream regulated 1 0.127309
RPS6 ribosomal protein S6 0.11239
PDE10A phosphodiesterase 10A 0.110989
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.108726
DST dystonin 0.0959903
GOLGA4 golgin A4 0.0928805
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0848485
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0842709
NAMPT nicotinamide phosphoribosyltransferase 0.0780126
SFTPA2 surfactant protein A2 0.0756077
HDAC9 histone deacetylase 9 0.066623
ADM adrenomedullin 0.0628314
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0605372
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.060506
FNIP1 folliculin interacting protein 1 0.0556661
OPTN optineurin 0.0541732
ATXN1 ataxin 1 0.0535106
MYH9 myosin, heavy chain 9, non-muscle 0.0499813
RPS8 ribosomal protein S8 0.0498674
SDK1 sidekick cell adhesion molecule 1 0.0491594
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0488473
JMJD1C jumonji domain containing 1C 0.048796
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0485004
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0480117
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0477075
RPS12 ribosomal protein S12 0.0474532
TENT5A terminal nucleotidyltransferase 5A 0.0456855
CDK19 cyclin-dependent kinase 19 0.0456707
MSN moesin 0.0455579
FRMD4A FERM domain containing 4A 0.0434541
TMF1 TATA element modulatory factor 1 0.0433407
RPS2 ribosomal protein S2 0.0427168
GOLGB1 golgin B1 0.0421565
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0418243
ELL2 elongation factor, RNA polymerase II, 2 0.0415819
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0406198
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0404696
FRMPD4 FERM and PDZ domain containing 4 0.0401708
ARRDC3 arrestin domain containing 3 0.040105
RPS3 ribosomal protein S3 0.0399514
RND3 Rho family GTPase 3 0.0394097
BRD2 bromodomain containing 2 0.0387728
CCNL1 cyclin L1 0.0386034
CDH13 cadherin 13 0.0384078
ZNF292 zinc finger protein 292 0.037328
RPS10 ribosomal protein S10 0.0372898
FBXO32 F-box protein 32 0.0363233
FNDC3B fibronectin type III domain containing 3B 0.035808
CADM1 cell adhesion molecule 1 0.0350144
RPL36 ribosomal protein L36 0.0348234
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0347814
FLNB filamin B, beta 0.0339935
BACE2 beta-site APP-cleaving enzyme 2 0.0338497
BCLAF1 BCL2-associated transcription factor 1 0.0334971
RPS19 ribosomal protein S19 0.0331592
SETD5 SET domain containing 5 0.0329618
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0329282
MT2A metallothionein 2A 0.0329003
FMNL2 formin-like 2 0.0328489
MLPH melanophilin 0.0322036
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0318824
LPP LIM domain containing preferred translocation partner in lipoma 0.0318387
KDM4C lysine (K)-specific demethylase 4C 0.0315629
PRELID2 PRELI domain containing 2 0.0311557
RUNX1 runt-related transcription factor 1 0.0306718
APLP2 amyloid beta (A4) precursor-like protein 2 0.0304996
SBF2 SET binding factor 2 0.0303716
RB1CC1 RB1-inducible coiled-coil 1 0.0299974
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0299462
PRRC2C proline-rich coiled-coil 2C 0.0289267
ZMIZ1 zinc finger, MIZ-type containing 1 0.028612
N4BP2L2 NEDD4 binding protein 2-like 2 0.0285169
ESYT2 extended synaptotagmin-like protein 2 0.0278591
IGFBP7 insulin-like growth factor binding protein 7 0.0278029
RPS13 ribosomal protein S13 0.0277175
RPL37A ribosomal protein L37a 0.0273824
AFF3 AF4/FMR2 family, member 3 0.0273214
TMEM132D transmembrane protein 132D 0.0272946
MACF1 microtubule-actin crosslinking factor 1 0.0271533
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0270742
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0268813
FAM219A family with sequence similarity 219, member A 0.0268086
ANO6 anoctamin 6 0.0263684
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0262793
BABAM2 BRISC and BRCA1 A complex member 2 0.0258786
STC2 stanniocalcin 2 0.0258376
CALD1 caldesmon 1 0.0256915
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0252638
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0251228
AKAP9 A kinase (PRKA) anchor protein 9 0.0246834
PDE4D phosphodiesterase 4D, cAMP-specific 0.0244457
INSIG1 insulin induced gene 1 0.0242912
IRAK2 interleukin-1 receptor-associated kinase 2 0.0239264
C3 complement component 3 0.0238893
FRMD5 FERM domain containing 5 0.0238746
EPHA6 EPH receptor A6 0.0238367
GPC6 glypican 6 0.0237552
FHIT fragile histidine triad 0.0235562

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.265631
FN1 fibronectin 1 -0.193574
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102952
RPS24 ribosomal protein S24 -0.0928391
PGK1 phosphoglycerate kinase 1 -0.0882881
LOC112694756 uncharaterized LOC112694756 -0.0848833
TMSB10 thymosin beta 10 -0.0837606
LDHA lactate dehydrogenase A -0.082183
BICC1 BicC family RNA binding protein 1 -0.0776433
FLNA filamin A, alpha -0.0763511
IER3 immediate early response 3 -0.0758788
AHNAK AHNAK nucleoprotein -0.0758185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0752345
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0741638
HLA-E major histocompatibility complex, class I, E -0.0680208
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0679651
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0674329
TUBB tubulin, beta class I -0.062612
SOD2 superoxide dismutase 2, mitochondrial -0.0618636
CANX calnexin -0.0617128
FTH1 ferritin, heavy polypeptide 1 -0.0615631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0595172
PCBP2 poly(rC) binding protein 2 -0.0588001
VDAC1 voltage-dependent anion channel 1 -0.0586067
THBS1 thrombospondin 1 -0.0585806
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0561839
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0545324
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.051292
FTL ferritin, light polypeptide -0.0499466
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0496695
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0489507
ANXA2 annexin A2 -0.0472054
KDM3A lysine (K)-specific demethylase 3A -0.0471166
TMSB4X thymosin beta 4, X-linked -0.0448581
SFRP1 secreted frizzled-related protein 1 -0.0447594
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0444796
RPL4 ribosomal protein L4 -0.0444301
VCL vinculin -0.0442252
LMAN1 lectin, mannose-binding, 1 -0.0430725
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0423763
TSC22D2 TSC22 domain family, member 2 -0.0422674
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0420801
RPLP1 ribosomal protein, large, P1 -0.041897
TPM4 tropomyosin 4 -0.0416582
ACTG1 actin gamma 1 -0.0401305
MORF4L2 mortality factor 4 like 2 -0.0390047
LOX lysyl oxidase -0.038844
RPL23 ribosomal protein L23 -0.038318
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0380146
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0377182
TKT transketolase -0.0359067
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0358726
POTEF POTE ankyrin domain family, member F -0.0357368
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0355652
RPLP0 ribosomal protein, large, P0 -0.0351542
RPL27A ribosomal protein L27a -0.0349805
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0349372
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0344439
PDIA3 protein disulfide isomerase family A, member 3 -0.0343729
RHOA ras homolog family member A -0.0342114
RPL35A ribosomal protein L35a -0.0341389
SPAG9 sperm associated antigen 9 -0.0340246
NPEPPS aminopeptidase puromycin sensitive -0.0339868
THBS2 thrombospondin 2 -0.0338364
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0337082
FAM20C family with sequence similarity 20, member C -0.0335684
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0333767
SDC4 syndecan 4 -0.0333214
COL1A1 collagen, type I, alpha 1 -0.0330962
REEP3 receptor accessory protein 3 -0.0328299
ARF1 ADP-ribosylation factor 1 -0.032741
TGFBI transforming growth factor, beta-induced, 68kDa -0.0326978
HDLBP high density lipoprotein binding protein -0.0316406
TMEM123 transmembrane protein 123 -0.0315761
RPL39 ribosomal protein L39 -0.0315081
NT5C2 5'-nucleotidase, cytosolic II -0.0311942
DEK DEK proto-oncogene -0.0308908
PLIN2 perilipin 2 -0.0308123
TAPBP TAP binding protein (tapasin) -0.0304359
WTAP Wilms tumor 1 associated protein -0.0304294
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0296885
ZFAND3 zinc finger, AN1-type domain 3 -0.0296023
TXNRD1 thioredoxin reductase 1 -0.0295725
RAD21 RAD21 homolog (S. pombe) -0.0290063
OSMR oncostatin M receptor -0.028946
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0285941
ENO1 enolase 1, (alpha) -0.0285914
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0285798
IFI16 interferon, gamma-inducible protein 16 -0.0285022
NCOA7 nuclear receptor coactivator 7 -0.0283503
DENND5A DENN/MADD domain containing 5A -0.0282358
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0281954
LAMP2 lysosomal-associated membrane protein 2 -0.0280128
NAP1L1 nucleosome assembly protein 1-like 1 -0.0279652
CAVIN1 caveolae associated protein 1 -0.0278837
TAOK1 TAO kinase 1 -0.0277359
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0265554
HLA-C major histocompatibility complex, class I, C -0.0263628
EPAS1 endothelial PAS domain protein 1 -0.0261281
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0259618