Daidzin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0572448
EFNA5 ephrin-A5 0.0407483
NAMPT nicotinamide phosphoribosyltransferase 0.0394414
FRMD6 FERM domain containing 6 0.0367652
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0350074
TRIO trio Rho guanine nucleotide exchange factor 0.0345144
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0340977
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0340157
LPP LIM domain containing preferred translocation partner in lipoma 0.0337306
TENT5A terminal nucleotidyltransferase 5A 0.0336576
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0329865
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322801
FNIP1 folliculin interacting protein 1 0.0321365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.031808
RSAD2 radical S-adenosyl methionine domain containing 2 0.0312319
ESYT2 extended synaptotagmin-like protein 2 0.0309204
ANO6 anoctamin 6 0.0305037
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0300792
SOD2 superoxide dismutase 2, mitochondrial 0.029147
MBD5 methyl-CpG binding domain protein 5 0.0290547
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0288064
PRELID2 PRELI domain containing 2 0.0285648
CENPF centromere protein F, 350/400kDa 0.0280874
ADAM9 ADAM metallopeptidase domain 9 0.027792
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0276867
MAML2 mastermind-like 2 (Drosophila) 0.0276239
ARRDC3 arrestin domain containing 3 0.0265335
FOXJ3 forkhead box J3 0.0265244
PARD3 par-3 family cell polarity regulator 0.0264987
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264353
YTHDC1 YTH domain containing 1 0.0260856
VEGFA vascular endothelial growth factor A 0.0259938
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257906
PRRC2C proline-rich coiled-coil 2C 0.0254072
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0252799
BCLAF1 BCL2-associated transcription factor 1 0.0248429
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0245908
MSN moesin 0.0240352
BIRC3 baculoviral IAP repeat containing 3 0.0231251
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0227958
YBX1 Y box binding protein 1 0.0227284
TBC1D23 TBC1 domain family, member 23 0.0225189
TTLL10 tubulin tyrosine ligase-like family member 10 0.0224394
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0223913
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0223763
SECISBP2L SECIS binding protein 2-like 0.0222499
XPO6 exportin 6 0.0222311
ANLN anillin, actin binding protein 0.0220059
USO1 USO1 vesicle transport factor 0.0219144
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0217904
ZCCHC7 zinc finger, CCHC domain containing 7 0.0216851
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0215846
UBA6 ubiquitin-like modifier activating enzyme 6 0.021535
POT1 protection of telomeres 1 0.0215173
EGR1 early growth response 1 0.0214175
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.021389
PTPRJ protein tyrosine phosphatase, receptor type, J 0.021247
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0211405
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0211171
AHR aryl hydrocarbon receptor 0.0210837
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0210296
SAMD4A sterile alpha motif domain containing 4A 0.0210214
SUCO SUN domain containing ossification factor 0.0209227
ATP13A3 ATPase type 13A3 0.0209067
MACF1 microtubule-actin crosslinking factor 1 0.0208673
IL6 interleukin 6 0.0208356
ELL2 elongation factor, RNA polymerase II, 2 0.020759
VEGFC vascular endothelial growth factor C 0.0206216
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.020537
BACE2 beta-site APP-cleaving enzyme 2 0.0204302
MCTP2 multiple C2 domains, transmembrane 2 0.0203012
RAD51B RAD51 paralog B 0.0202892
ETV6 ets variant 6 0.0202012
ADAM17 ADAM metallopeptidase domain 17 0.0201307
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0201119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0201108
SEPTIN9 septin 9 0.0200606
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0199996
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0199072
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.0198678
OXSR1 oxidative stress responsive 1 0.0198339
PDE4D phosphodiesterase 4D, cAMP-specific 0.0197597
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.019734
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0196452
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0195646
VPS26C VPS26 endosomal protein sorting factor C 0.0195335
NPC1 Niemann-Pick disease, type C1 0.019503
CACUL1 CDK2-associated, cullin domain 1 0.019494
NUSAP1 nucleolar and spindle associated protein 1 0.0193925
RIGI RNA sensor RIG-I 0.0193839
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0193776
ERBIN erbb2 interacting protein 0.0193273
NDRG1 N-myc downstream regulated 1 0.0192602
WDR41 WD repeat domain 41 0.0190808
FRYL FRY-like 0.0190494
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0189945
BRWD3 bromodomain and WD repeat domain containing 3 0.0189938
SMYD3 SET and MYND domain containing 3 0.0188947
SCFD1 sec1 family domain containing 1 0.0188544
MRPS6 mitochondrial ribosomal protein S6 0.0186742

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.259354
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24101
IGFBP3 insulin-like growth factor binding protein 3 -0.205763
MT2A metallothionein 2A -0.169844
VIM vimentin -0.16832
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141906
FTL ferritin, light polypeptide -0.13875
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.128309
FN1 fibronectin 1 -0.10581
LOX lysyl oxidase -0.0922552
HLA-B major histocompatibility complex, class I, B -0.090919
PRSS23 protease, serine, 23 -0.0888605
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0856615
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.083353
MAP1B microtubule-associated protein 1B -0.0794634
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0768983
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0762997
TGFBI transforming growth factor, beta-induced, 68kDa -0.0746664
CALD1 caldesmon 1 -0.073118
PKM pyruvate kinase, muscle -0.0719743
CDH13 cadherin 13 -0.0706113
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0705288
AHNAK AHNAK nucleoprotein -0.0687779
CALU calumenin -0.0685237
F3 coagulation factor III (thromboplastin, tissue factor) -0.0668729
LOC112694756 uncharaterized LOC112694756 -0.0658328
EGFR epidermal growth factor receptor -0.0647276
COL6A3 collagen, type VI, alpha 3 -0.0620232
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0590506
MEF2A myocyte enhancer factor 2A -0.0586405
MT1X metallothionein 1X -0.0557537
ANXA2 annexin A2 -0.0552819
TPM4 tropomyosin 4 -0.054991
COL6A1 collagen, type VI, alpha 1 -0.0497807
STC1 stanniocalcin 1 -0.049758
CANX calnexin -0.0496941
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.048738
SDC4 syndecan 4 -0.0484931
ZMYND8 zinc finger, MYND-type containing 8 -0.0482987
MORF4L2 mortality factor 4 like 2 -0.0480939
RPL35A ribosomal protein L35a -0.0479476
PDIA3 protein disulfide isomerase family A, member 3 -0.0479314
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0458971
B2M beta-2-microglobulin -0.0458398
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0454564
HLA-C major histocompatibility complex, class I, C -0.0448635
ACTG1 actin gamma 1 -0.0443287
GLG1 golgi glycoprotein 1 -0.0431049
FLNA filamin A, alpha -0.0424401
LOXL2 lysyl oxidase-like 2 -0.0420132
LMAN1 lectin, mannose-binding, 1 -0.0412821
HLA-A major histocompatibility complex, class I, A -0.0411729
HIP1 huntingtin interacting protein 1 -0.0395917
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.039053
ZNF395 zinc finger protein 395 -0.0388439
HDLBP high density lipoprotein binding protein -0.0379374
CALR calreticulin -0.0374177
RNF145 ring finger protein 145 -0.0370527
VCL vinculin -0.036005
CAV1 caveolin 1, caveolae protein, 22kDa -0.0356734
EIF1 eukaryotic translation initiation factor 1 -0.035318
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.034784
CLIC4 chloride intracellular channel 4 -0.0340992
S100A10 S100 calcium binding protein A10 -0.0336006
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0334909
ECE1 endothelin converting enzyme 1 -0.0332223
INSIG2 insulin induced gene 2 -0.0330514
PGK1 phosphoglycerate kinase 1 -0.0329757
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0324475
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0320618
COL1A1 collagen, type I, alpha 1 -0.031861
CLTC clathrin, heavy chain (Hc) -0.0316254
AFF4 AF4/FMR2 family, member 4 -0.0313815
RPL5 ribosomal protein L5 -0.0313254
RAB10 RAB10, member RAS oncogene family -0.0310353
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0307981
IGFBP7 insulin-like growth factor binding protein 7 -0.0307556
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.030692
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0305181
COL5A1 collagen, type V, alpha 1 -0.0300801
RPS14 ribosomal protein S14 -0.0298472
DPYD dihydropyrimidine dehydrogenase -0.0297806
ENO1 enolase 1, (alpha) -0.0297677
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0297017
PTN pleiotrophin -0.0292485
AKAP12 A kinase (PRKA) anchor protein 12 -0.0292084
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0289428
NRP1 neuropilin 1 -0.0289091
RRBP1 ribosome binding protein 1 -0.0286535
RPL28 ribosomal protein L28 -0.0284678
CAVIN1 caveolae associated protein 1 -0.0284312
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0281332
EPAS1 endothelial PAS domain protein 1 -0.0281162
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0280552
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0279924
RPL34 ribosomal protein L34 -0.027767
SKP1 S-phase kinase-associated protein 1 -0.0277306
SPDYA speedy/RINGO cell cycle regulator family member A -0.0276468
TTC3 tetratricopeptide repeat domain 3 -0.0270609
JMJD1C jumonji domain containing 1C -0.0263789