Daidzin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANKRD11 ankyrin repeat domain 11 0.084467
PTMA prothymosin, alpha 0.0762696
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0721221
GOLGA4 golgin A4 0.0707068
MYH9 myosin, heavy chain 9, non-muscle 0.0659029
ZNF292 zinc finger protein 292 0.0579563
MKI67 marker of proliferation Ki-67 0.0577619
PRELID2 PRELI domain containing 2 0.057056
HILPDA hypoxia inducible lipid droplet-associated 0.0552199
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0548247
CENPF centromere protein F, 350/400kDa 0.0502811
SPAG9 sperm associated antigen 9 0.0501182
RABGAP1 RAB GTPase activating protein 1 0.0497294
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0491288
TPX2 TPX2, microtubule-associated 0.0486715
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0480286
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.046992
SPTBN1 spectrin, beta, non-erythrocytic 1 0.046585
SETD5 SET domain containing 5 0.0457608
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0453979
ANKRD36 ankyrin repeat domain 36 0.0445648
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.043786
FNDC3B fibronectin type III domain containing 3B 0.0437693
ERBIN erbb2 interacting protein 0.0421431
QKI QKI, KH domain containing, RNA binding 0.0417303
CCDC88A coiled-coil domain containing 88A 0.0415583
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0415307
JAK1 Janus kinase 1 0.0414859
ANKRD37 ankyrin repeat domain 37 0.041179
INSIG1 insulin induced gene 1 0.0399574
LMO7 LIM domain 7 0.039833
YME1L1 YME1-like 1 ATPase 0.0397628
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0392734
APOLD1 apolipoprotein L domain containing 1 0.0391689
PRRC2C proline-rich coiled-coil 2C 0.0385948
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0383259
NAMPT nicotinamide phosphoribosyltransferase 0.0381433
PUM2 pumilio RNA-binding family member 2 0.037294
KIF5B kinesin family member 5B 0.037028
ADM adrenomedullin 0.0368822
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0368391
CAPRIN2 caprin family member 2 0.0368025
CKAP5 cytoskeleton associated protein 5 0.036754
BABAM2 BRISC and BRCA1 A complex member 2 0.036432
BASP1 brain abundant, membrane attached signal protein 1 0.0360972
RAD23B RAD23 homolog B (S. cerevisiae) 0.0356562
CALR calreticulin 0.0354821
TPI1 triosephosphate isomerase 1 0.035334
DIAPH3 diaphanous-related formin 3 0.034557
NHSL1 NHS-like 1 0.034548
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0337791
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0334507
MCTP1 multiple C2 domains, transmembrane 1 0.0330123
TPM3 tropomyosin 3 0.0326366
FAM168A family with sequence similarity 168, member A 0.0324931
NCOA1 nuclear receptor coactivator 1 0.0320521
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.032003
EML4 echinoderm microtubule associated protein like 4 0.0320024
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0319054
ZMYND8 zinc finger, MYND-type containing 8 0.0318674
CEP250 centrosomal protein 250kDa 0.0318357
RBM6 RNA binding motif protein 6 0.031791
MACF1 microtubule-actin crosslinking factor 1 0.0316608
WWOX WW domain containing oxidoreductase 0.0315678
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.031496
ZNF638 zinc finger protein 638 0.0314458
CALU calumenin 0.0313123
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0310521
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.031045
FAR1 fatty acyl CoA reductase 1 0.0306068
NAV2 neuron navigator 2 0.0305664
PNISR PNN-interacting serine/arginine-rich protein 0.0305658
TMF1 TATA element modulatory factor 1 0.030526
TRA2A transformer 2 alpha homolog (Drosophila) 0.0304126
ESYT2 extended synaptotagmin-like protein 2 0.0300151
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0299421
MT2A metallothionein 2A 0.0298418
SNX14 sorting nexin 14 0.0298015
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0296072
MSN moesin 0.0295982
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0295696
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0293436
GGT7 gamma-glutamyltransferase 7 0.0291623
EIF5B eukaryotic translation initiation factor 5B 0.0290895
MED4 mediator complex subunit 4 0.0289143
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0287188
ACTN1 actinin, alpha 1 0.0286695
MEF2A myocyte enhancer factor 2A 0.0286421
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0286267
KDM2A lysine (K)-specific demethylase 2A 0.0285988
ARRDC3 arrestin domain containing 3 0.0285938
RSF1 remodeling and spacing factor 1 0.0283827
TRIM37 tripartite motif containing 37 0.0283436
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0282388
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0279022
USP47 ubiquitin specific peptidase 47 0.0278795
MUSK muscle, skeletal, receptor tyrosine kinase 0.0277525
ANLN anillin, actin binding protein 0.0275031
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0274495
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0274278

decreased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 -0.0982604
VIM vimentin -0.0898608
DSCAM Down syndrome cell adhesion molecule -0.0822551
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0690744
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0606014
CD44 CD44 molecule (Indian blood group) -0.0578207
OSMR oncostatin M receptor -0.0534902
NCEH1 neutral cholesterol ester hydrolase 1 -0.0527078
LDHA lactate dehydrogenase A -0.0518912
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0497375
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0463161
NIPBL Nipped-B homolog (Drosophila) -0.0458645
EGR1 early growth response 1 -0.0457333
TMSB10 thymosin beta 10 -0.0437165
PRH1 proline-rich protein HaeIII subfamily 1 -0.0435385
MBD5 methyl-CpG binding domain protein 5 -0.0418748
FBXL2 F-box and leucine-rich repeat protein 2 -0.0412028
FBXL7 F-box and leucine-rich repeat protein 7 -0.0384344
GLS2 glutaminase 2 (liver, mitochondrial) -0.0380816
ANXA2 annexin A2 -0.0378789
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0378403
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0372671
PHACTR4 phosphatase and actin regulator 4 -0.0370973
JMJD1C jumonji domain containing 1C -0.0355823
RPL30 ribosomal protein L30 -0.0354143
RPL35A ribosomal protein L35a -0.0352932
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0349717
VCL vinculin -0.0349326
BSG basigin (Ok blood group) -0.0348543
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0345312
SVIL supervillin -0.0340246
BIRC2 baculoviral IAP repeat containing 2 -0.0339497
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0337831
TAS2R14 taste receptor, type 2, member 14 -0.0335351
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0334655
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0331887
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.032852
TTC3 tetratricopeptide repeat domain 3 -0.0328007
GNAS GNAS complex locus -0.0327888
SLC38A2 solute carrier family 38, member 2 -0.0327002
NABP1 nucleic acid binding protein 1 -0.0323183
CENPP centromere protein P -0.0321827
HDLBP high density lipoprotein binding protein -0.0321212
ASPH aspartate beta-hydroxylase -0.0316304
RPLP1 ribosomal protein, large, P1 -0.0314442
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0309071
IFIH1 interferon induced with helicase C domain 1 -0.0308194
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0307876
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -0.0303783
IGFBP3 insulin-like growth factor binding protein 3 -0.0301135
DNAH14 dynein, axonemal, heavy chain 14 -0.0300572
UBB ubiquitin B -0.0299943
SMYD3 SET and MYND domain containing 3 -0.0295778
APLP2 amyloid beta (A4) precursor-like protein 2 -0.029343
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0292296
CLASP2 cytoplasmic linker associated protein 2 -0.0291724
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0291566
ZC3H12B zinc finger CCCH-type containing 12B -0.0290742
CREBBP CREB binding protein -0.0289711
FSCN1 fascin actin-bundling protein 1 -0.0288548
CDYL chromodomain protein, Y-like -0.0284884
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0284627
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0282007
NBEAL1 neurobeachin-like 1 -0.0281661
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0280395
ZFAND3 zinc finger, AN1-type domain 3 -0.027977
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.02776
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0271589
RPL4 ribosomal protein L4 -0.0270865
RAB1A RAB1A, member RAS oncogene family -0.0270333
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0270284
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0268869
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0267488
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0263302
CTNND1 catenin (cadherin-associated protein), delta 1 -0.026314
PTK2 protein tyrosine kinase 2 -0.0261724
PTPRK protein tyrosine phosphatase, receptor type, K -0.0261394
TRIO trio Rho guanine nucleotide exchange factor -0.0261034
ZBTB44 zinc finger and BTB domain containing 44 -0.0259537
RDX radixin -0.0259478
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0259038
HLA-C major histocompatibility complex, class I, C -0.0258755
FKBP10 FK506 binding protein 10, 65 kDa -0.0258277
BZW1 basic leucine zipper and W2 domains 1 -0.0255581
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0255031
CLIP1 CAP-GLY domain containing linker protein 1 -0.0254969
CCDC82 coiled-coil domain containing 82 -0.025394
EXOC2 exocyst complex component 2 -0.0253919
ATM ATM serine/threonine kinase -0.0251332
ETF1 eukaryotic translation termination factor 1 -0.0251321
SQSTM1 sequestosome 1 -0.0250909
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0250068
FAF2 Fas associated factor family member 2 -0.024994
NALCN sodium leak channel, non selective -0.0249877
ERCC8 excision repair cross-complementation group 8 -0.0249345
SOD2 superoxide dismutase 2, mitochondrial -0.0247846
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0247472
WSB1 WD repeat and SOCS box containing 1 -0.0246881
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0246109
RYBP RING1 and YY1 binding protein -0.0245497