Daidzin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.11391
VEGFA vascular endothelial growth factor A 0.0855376
NDRG1 N-myc downstream regulated 1 0.0851868
TXNIP thioredoxin interacting protein 0.0712684
SFTPA2 surfactant protein A2 0.0660363
AKAP9 A kinase (PRKA) anchor protein 9 0.0604377
FAM13A family with sequence similarity 13, member A 0.0556937
IFI27 interferon, alpha-inducible protein 27 0.055323
GOLGA4 golgin A4 0.0525221
MYH9 myosin, heavy chain 9, non-muscle 0.0523381
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0504976
TPR translocated promoter region, nuclear basket protein 0.05048
ENO2 enolase 2 (gamma, neuronal) 0.0498372
AKAP12 A kinase (PRKA) anchor protein 12 0.0493617
PRRC2C proline-rich coiled-coil 2C 0.0492385
MKI67 marker of proliferation Ki-67 0.0464684
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0459887
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0458887
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0444271
TMF1 TATA element modulatory factor 1 0.0423797
SUCO SUN domain containing ossification factor 0.0407385
NPAS2 neuronal PAS domain protein 2 0.0407251
PRELID2 PRELI domain containing 2 0.0403529
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0400492
PTMA prothymosin, alpha 0.0391173
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0386154
MCTP2 multiple C2 domains, transmembrane 2 0.036881
STC2 stanniocalcin 2 0.0363085
B2M beta-2-microglobulin 0.0361557
CD109 CD109 molecule 0.0357694
VEGFC vascular endothelial growth factor C 0.0354645
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0347118
DST dystonin 0.0347037
EXT1 exostosin glycosyltransferase 1 0.0343311
SEC23A Sec23 homolog A (S. cerevisiae) 0.0340719
ZNF292 zinc finger protein 292 0.0339311
HDGF hepatoma-derived growth factor 0.0336459
OGA O-GlcNAcase 0.0322922
RPS27 ribosomal protein S27 0.0315333
LOC102724023 ES1 protein homolog, mitochondrial 0.0313603
NAMPT nicotinamide phosphoribosyltransferase 0.0313301
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.030392
BASP1 brain abundant, membrane attached signal protein 1 0.0303657
EIF4B eukaryotic translation initiation factor 4B 0.0303415
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0300809
RPL11 ribosomal protein L11 0.0300761
TTC3 tetratricopeptide repeat domain 3 0.0300326
ARRDC3 arrestin domain containing 3 0.0299507
RPS6 ribosomal protein S6 0.0297429
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0295264
RICTOR RPTOR independent companion of MTOR, complex 2 0.0294171
GOLT1B golgi transport 1B 0.0292375
N4BP2L2 NEDD4 binding protein 2-like 2 0.029195
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0289329
SHB Src homology 2 domain containing adaptor protein B 0.0288052
CUL3 cullin 3 0.0286186
CDC73 cell division cycle 73 0.027818
RPL3 ribosomal protein L3 0.0276643
CENPF centromere protein F, 350/400kDa 0.0276413
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0275525
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268458
SOX4 SRY (sex determining region Y)-box 4 0.0264299
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0261216
PNN pinin, desmosome associated protein 0.0258612
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0257836
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0257302
ZNF146 zinc finger protein 146 0.0256918
TRIO trio Rho guanine nucleotide exchange factor 0.0256897
TBC1D22A TBC1 domain family, member 22A 0.0253673
FNBP1 formin binding protein 1 0.0253606
ACIN1 apoptotic chromatin condensation inducer 1 0.0252653
TMED9 transmembrane emp24 protein transport domain containing 9 0.024758
TMSB10 thymosin beta 10 0.0247326
CAB39 calcium binding protein 39 0.0246211
ARHGAP35 Rho GTPase activating protein 35 0.023784
SOS1 son of sevenless homolog 1 (Drosophila) 0.0235431
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0234851
RBM25 RNA binding motif protein 25 0.023341
SFPQ splicing factor proline/glutamine-rich 0.0230845
HSPA8 heat shock 70kDa protein 8 0.0229209
ZNF160 zinc finger protein 160 0.0229106
SDE2 SDE2 telomere maintenance homolog (S. pombe) 0.0228892
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0227685
DOCK5 dedicator of cytokinesis 5 0.0226206
HMGB3 high mobility group box 3 0.0222701
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0222545
SQSTM1 sequestosome 1 0.0221143
RNF115 ring finger protein 115 0.0220159
RPS29 ribosomal protein S29 0.0219058
GRB10 growth factor receptor-bound protein 10 0.0217587
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0215595
GCC2 GRIP and coiled-coil domain containing 2 0.0214326
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0213003
S100A9 S100 calcium binding protein A9 0.021286
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0211657
FLNB filamin B, beta 0.0209466
RPS21 ribosomal protein S21 0.0209192
MSN moesin 0.0208556
RPL37A ribosomal protein L37a 0.0208097
GIGYF2 GRB10 interacting GYF protein 2 0.020658

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.283669
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.16129
CXCL8 chemokine (C-X-C motif) ligand 8 -0.144525
FN1 fibronectin 1 -0.14018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137605
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111904
HMGA2 high mobility group AT-hook 2 -0.111337
NRG1 neuregulin 1 -0.102205
VIM vimentin -0.0925651
FTH1 ferritin, heavy polypeptide 1 -0.0775902
CANX calnexin -0.0702324
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.057261
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0565377
INTS6 integrator complex subunit 6 -0.0555475
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0524042
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0497567
RPS24 ribosomal protein S24 -0.0478851
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0469021
HILPDA hypoxia inducible lipid droplet-associated -0.0463773
SPDYA speedy/RINGO cell cycle regulator family member A -0.0441332
ARF1 ADP-ribosylation factor 1 -0.0430969
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0420913
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0416903
PDIA3 protein disulfide isomerase family A, member 3 -0.041549
SEPTIN7 septin 7 -0.0415099
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0411389
IL6ST interleukin 6 signal transducer -0.0407039
PCBP2 poly(rC) binding protein 2 -0.0398929
IER3 immediate early response 3 -0.0377755
HMGA1 high mobility group AT-hook 1 -0.0376329
EFNA5 ephrin-A5 -0.0373854
AHR aryl hydrocarbon receptor -0.0369831
RPLP1 ribosomal protein, large, P1 -0.0356296
WDR45B WD repeat domain 45B -0.0354546
LRRC23 leucine rich repeat containing 23 -0.0353203
TSC22D2 TSC22 domain family, member 2 -0.0352915
RPLP0 ribosomal protein, large, P0 -0.0351299
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0343326
IGFBP3 insulin-like growth factor binding protein 3 -0.0341542
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0340453
PALLD palladin, cytoskeletal associated protein -0.0340295
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0330844
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0327641
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0325779
ACTG1 actin gamma 1 -0.0319104
CADM1 cell adhesion molecule 1 -0.0318591
TMEM165 transmembrane protein 165 -0.0316862
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0315551
RPS25 ribosomal protein S25 -0.031455
RAP1B RAP1B, member of RAS oncogene family -0.031153
SDCBP syndecan binding protein (syntenin) -0.0309826
GNAS GNAS complex locus -0.0308799
DSTN destrin (actin depolymerizing factor) -0.0305132
VDAC1 voltage-dependent anion channel 1 -0.0298302
TFG TRK-fused gene -0.0290196
PDLIM5 PDZ and LIM domain 5 -0.0287138
LOC112694756 uncharaterized LOC112694756 -0.0284465
BICD1 bicaudal D homolog 1 (Drosophila) -0.0280101
RHOA ras homolog family member A -0.027983
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0274784
RPS16 ribosomal protein S16 -0.0270855
NIPBL Nipped-B homolog (Drosophila) -0.027074
IL6 interleukin 6 -0.0265846
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.026393
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0263733
BSG basigin (Ok blood group) -0.0261931
PARD3 par-3 family cell polarity regulator -0.0259742
POTEF POTE ankyrin domain family, member F -0.0259226
TPM4 tropomyosin 4 -0.0254792
NUP58 nucleoporin 58 -0.025272
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0250976
RPL35A ribosomal protein L35a -0.0248544
MBNL1 muscleblind-like splicing regulator 1 -0.0248146
ODR4 odr-4 GPCR localization factor homolog -0.0247467
FLNA filamin A, alpha -0.0246302
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0246102
SOD2 superoxide dismutase 2, mitochondrial -0.0237812
BZW2 basic leucine zipper and W2 domains 2 -0.023553
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.023522
RPL12 ribosomal protein L12 -0.0231591
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0231197
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0230124
MTSS1 metastasis suppressor 1 -0.0228698
AEBP2 AE binding protein 2 -0.0227156
GLIS3 GLIS family zinc finger 3 -0.0226983
RYBP RING1 and YY1 binding protein -0.0224592
PTK2 protein tyrosine kinase 2 -0.0224251
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0222901
ATP11B ATPase, class VI, type 11B -0.0222442
RAB7A RAB7A, member RAS oncogene family -0.0220416
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0219703
USP34 ubiquitin specific peptidase 34 -0.0219096
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0218839
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0215779
TMEM131 transmembrane protein 131 -0.0215624
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0215249
ALCAM activated leukocyte cell adhesion molecule -0.0214143
TMEM123 transmembrane protein 123 -0.0213493
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0213311
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0213245