| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. (Chemical Entities of Biological Interest Ontology, CHEBI_4317) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6914273 |
| Similar Terms | |
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198 proteins with high or low expression in Dantrolene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCPKMT | valosin containing protein lysine (K) methyltransferase | 2.66 |
| KLHDC10 | kelch domain containing 10 | 2.25 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 2.08 |
| PIP | prolactin-induced protein | 1.19 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.18 |
| ERG28 | ergosterol biosynthesis 28 homolog | 1.03 |
| H1-3 | H1.3 linker histone, cluster member | 0.88 |
| CACYBP | calcyclin binding protein | 0.87 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.8 |
| PVR | poliovirus receptor | 0.74 |
| H2AFX | H2A histone family, member X | 0.7 |
| KLHL8 | kelch-like family member 8 | 0.65 |
| ARPC5L | actin related protein 2/3 complex, subunit 5-like | 0.61 |
| PIGK | phosphatidylinositol glycan anchor biosynthesis, class K | 0.6 |
| UCK1 | uridine-cytidine kinase 1 | 0.6 |
| YEATS4 | YEATS domain containing 4 | 0.6 |
| MAGEB1 | melanoma antigen family B1 | 0.59 |
| RPL23A | ribosomal protein L23a | 0.59 |
| NHP2 | NHP2 ribonucleoprotein | 0.58 |
| NAXE | NAD(P)HX epimerase | 0.57 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | 0.56 |
| CDK10 | cyclin-dependent kinase 10 | 0.56 |
| PFN2 | profilin 2 | 0.56 |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide | 0.55 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.55 |
| ZNF675 | zinc finger protein 675 | 0.53 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.53 |
| TMEM135 | transmembrane protein 135 | 0.53 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.53 |
| USP48 | ubiquitin specific peptidase 48 | 0.52 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.51 |
| TCHP | trichoplein, keratin filament binding | 0.51 |
| BBS7 | Bardet-Biedl syndrome 7 | 0.51 |
| PLCB4 | phospholipase C, beta 4 | 0.51 |
| PPID | peptidylprolyl isomerase D | 0.51 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.49 |
| RPL28 | ribosomal protein L28 | 0.49 |
| ODC1 | ornithine decarboxylase 1 | 0.49 |
| NOS1 | nitric oxide synthase 1 (neuronal) | 0.49 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.48 |
| TCP11L2 | t-complex 11, testis-specific-like 2 | 0.48 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.48 |
| TET3 | tet methylcytosine dioxygenase 3 | 0.48 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.47 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | 0.47 |
| RPS5 | ribosomal protein S5 | 0.45 |
| STX10 | syntaxin 10 | 0.45 |
| OPHN1 | oligophrenin 1 | 0.45 |
| ARMT1 | acidic residue methyltransferase 1 | 0.45 |
| MIS12 | MIS12 kinetochore complex component | 0.45 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | 0.44 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.44 |
| KIAA0753 | KIAA0753 | 0.44 |
| RPL36AL | ribosomal protein L36a-like | 0.44 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | 0.42 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.42 |
| OTUD7B | OTU deubiquitinase 7B | 0.42 |
| MADD | MAP-kinase activating death domain | 0.41 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 0.41 |
| NMD3 | NMD3 ribosome export adaptor | 0.41 |
| EPHA5 | EPH receptor A5 | 0.41 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.41 |
| PRR3 | proline rich 3 | 0.41 |
| TOB2 | transducer of ERBB2, 2 | 0.4 |
| DTNB | dystrobrevin, beta | 0.4 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.4 |
| CYCS | cytochrome c, somatic | 0.4 |
| XPO1 | exportin 1 | 0.4 |
| RPL15 | ribosomal protein L15 | 0.4 |
| USP18 | ubiquitin specific peptidase 18 | 0.4 |
| CYC1 | cytochrome c-1 | 0.4 |
| CDC25B | cell division cycle 25B | 0.39 |
| TGOLN2 | trans-golgi network protein 2 | 0.39 |
| ICA1L | islet cell autoantigen 1,69kDa-like | 0.39 |
| SUCO | SUN domain containing ossification factor | 0.39 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.39 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.39 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.38 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.38 |
| HOXA7 | homeobox A7 | 0.37 |
| RPL8 | ribosomal protein L8 | 0.37 |
| DAP | death-associated protein | 0.37 |
| H2AZ1 | H2A.Z variant histone 1 | 0.37 |
| EIF4E2 | eukaryotic translation initiation factor 4E family member 2 | 0.37 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.37 |
| MRPL20 | mitochondrial ribosomal protein L20 | 0.37 |
| METAP2 | methionyl aminopeptidase 2 | 0.36 |
| GANAB | glucosidase, alpha; neutral AB | 0.36 |
| MYH16 | myosin, heavy chain 16 pseudogene | 0.36 |
| MED16 | mediator complex subunit 16 | 0.36 |
| TMEM97 | transmembrane protein 97 | 0.36 |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | 0.36 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.36 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.35 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.35 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.35 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | 0.35 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.35 |
| TPD52 | tumor protein D52 | 0.35 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | 0.35 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.9 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -1.6 |
| JAK3 | Janus kinase 3 | -1.31 |
| HSPA8 | heat shock 70kDa protein 8 | -1.29 |
| OTC | ornithine carbamoyltransferase | -1.06 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -1.05 |
| CEP63 | centrosomal protein 63kDa | -1.05 |
| RITA1 | RBPJ interacting and tubulin associated 1 | -1.0 |
| PLA2G12A | phospholipase A2, group XIIA | -0.88 |
| ZNF584 | zinc finger protein 584 | -0.84 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.82 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.8 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.79 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.79 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.78 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.76 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.72 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.72 |
| CKM | creatine kinase, muscle | -0.7 |
| FEM1C | fem-1 homolog c (C. elegans) | -0.7 |
| ZNRD2 | zinc ribbon domain containing 2 | -0.67 |
| CEP128 | centrosomal protein 128kDa | -0.63 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.62 |
| FNIP1 | folliculin interacting protein 1 | -0.62 |
| TTYH3 | tweety family member 3 | -0.59 |
| FBXO44 | F-box protein 44 | -0.58 |
| TUBAL3 | tubulin, alpha-like 3 | -0.54 |
| KLK6 | kallikrein-related peptidase 6 | -0.54 |
| CILP2 | cartilage intermediate layer protein 2 | -0.52 |
| CCND3 | cyclin D3 | -0.51 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.5 |
| KCTD5 | potassium channel tetramerization domain containing 5 | -0.48 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.48 |
| ACTBL2 | actin, beta-like 2 | -0.48 |
| FICD | FIC domain containing | -0.48 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.47 |
| RPL36A | ribosomal protein L36a | -0.47 |
| SPIN2B | spindlin family, member 2B | -0.46 |
| ALKBH2 | alkB, alkylation repair homolog 2 (E. coli) | -0.46 |
| MT2A | metallothionein 2A | -0.46 |
| SYK | spleen tyrosine kinase | -0.46 |
| MT1X | metallothionein 1X | -0.46 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.46 |
| SEPTIN7 | septin 7 | -0.45 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | -0.45 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.45 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.43 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.43 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.43 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.42 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.42 |
| DCTN5 | dynactin 5 (p25) | -0.42 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.42 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.41 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.41 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.41 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.41 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.4 |
| MYO15B | myosin XVB | -0.4 |
| ATP9A | ATPase, class II, type 9A | -0.39 |
| CNTNAP3 | contactin associated protein-like 3 | -0.39 |
| EMP3 | epithelial membrane protein 3 | -0.38 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.38 |
| TBX3 | T-box 3 | -0.38 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.38 |
| ZFAT | zinc finger and AT hook domain containing | -0.38 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | -0.38 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | -0.38 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.37 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.37 |
| GDF15 | growth differentiation factor 15 | -0.37 |
| ABHD2 | abhydrolase domain containing 2 | -0.37 |
| BCL9 | B-cell CLL/lymphoma 9 | -0.37 |
| FTL | ferritin, light polypeptide | -0.36 |
| PMFBP1 | polyamine modulated factor 1 binding protein 1 | -0.36 |
| SELENOK | selenoprotein K | -0.36 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.35 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.35 |
| NMU | neuromedin U | -0.35 |
| NADK | NAD kinase | -0.35 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.35 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.35 |
| CD46 | CD46 molecule, complement regulatory protein | -0.34 |
| COMMD7 | COMM domain containing 7 | -0.34 |
| ZNF91 | zinc finger protein 91 | -0.34 |
| EHF | ets homologous factor | -0.34 |
| CMC1 | C-x(9)-C motif containing 1 | -0.34 |
| MYO15A | myosin XVA | -0.34 |
| DUOX1 | dual oxidase 1 | -0.34 |
| TMEM41B | transmembrane protein 41B | -0.34 |
| SERINC5 | serine incorporator 5 | -0.33 |
| OTX1 | orthodenticle homeobox 1 | -0.33 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.33 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.33 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.33 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -0.32 |
| HYAL2 | hyaluronoglucosaminidase 2 | -0.32 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.32 |
