| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.221827 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.208875 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.135609 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.132554 |
| LOXL2 | lysyl oxidase-like 2 | 0.126908 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.103306 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0892491 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0872448 |
| FBN1 | fibrillin 1 | 0.0862433 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0821149 |
| MYOF | myoferlin | 0.0796951 |
| COL5A1 | collagen, type V, alpha 1 | 0.0796901 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0772262 |
| SEPTIN9 | septin 9 | 0.0745175 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0732015 |
| NDRG1 | N-myc downstream regulated 1 | 0.0722544 |
| APP | amyloid beta (A4) precursor protein | 0.0715109 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0710081 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0703131 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.068973 |
| FLNB | filamin B, beta | 0.0678393 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0678187 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0645314 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0624228 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0614439 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0572281 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0551179 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0545407 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0544773 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0533506 |
| PCBP2 | poly(rC) binding protein 2 | 0.049764 |
| NAV2 | neuron navigator 2 | 0.0487316 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0484699 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0472351 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0469496 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0463828 |
| POTEF | POTE ankyrin domain family, member F | 0.0450762 |
| DST | dystonin | 0.0444454 |
| ATP13A3 | ATPase type 13A3 | 0.0440825 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.043842 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0422041 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0420757 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0408942 |
| SETD5 | SET domain containing 5 | 0.0402139 |
| MSI2 | musashi RNA-binding protein 2 | 0.0401855 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0400225 |
| PGK1 | phosphoglycerate kinase 1 | 0.0399923 |
| HDAC9 | histone deacetylase 9 | 0.0399764 |
| RUNX1 | runt-related transcription factor 1 | 0.0397888 |
| AHNAK | AHNAK nucleoprotein | 0.0396184 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0395835 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0395343 |
| FLNA | filamin A, alpha | 0.039184 |
| TPM3 | tropomyosin 3 | 0.0386885 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0377106 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0374739 |
| AFAP1 | actin filament associated protein 1 | 0.0360507 |
| CD109 | CD109 molecule | 0.0359077 |
| L1CAM | L1 cell adhesion molecule | 0.0356236 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0351247 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.034774 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0347451 |
| CTBP2 | C-terminal binding protein 2 | 0.0346368 |
| MSN | moesin | 0.0341682 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0341469 |
| C1D | C1D nuclear receptor corepressor | 0.0339274 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0332341 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0330541 |
| LDHA | lactate dehydrogenase A | 0.0325243 |
| HELZ | helicase with zinc finger | 0.0324727 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0324675 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0324437 |
| NCOR2 | nuclear receptor corepressor 2 | 0.032194 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0320267 |
| SH3BP2 | SH3-domain binding protein 2 | 0.0317127 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0316013 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0315439 |
| SQSTM1 | sequestosome 1 | 0.0314416 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0312233 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0305932 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0299326 |
| PLEC | plectin | 0.0299227 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0298717 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0298338 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0298055 |
| AUTS2 | autism susceptibility candidate 2 | 0.0296142 |
| NBAS | neuroblastoma amplified sequence | 0.0288924 |
| COL5A2 | collagen, type V, alpha 2 | 0.0286214 |
| MED13L | mediator complex subunit 13-like | 0.0285086 |
| COL3A1 | collagen, type III, alpha 1 | 0.0284288 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0282352 |
| CDH13 | cadherin 13 | 0.0280917 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0280883 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0280376 |
| B2M | beta-2-microglobulin | 0.0279466 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0279235 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0278318 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0275701 |
| DENND5A | DENN/MADD domain containing 5A | 0.0268716 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0265669 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.230791 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139994 |
| VIM | vimentin | -0.0782129 |
| LOX | lysyl oxidase | -0.0719245 |
| TMSB10 | thymosin beta 10 | -0.0704983 |
| S100A10 | S100 calcium binding protein A10 | -0.0636046 |
| MT2A | metallothionein 2A | -0.051664 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0494605 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0398253 |
| MEIS2 | Meis homeobox 2 | -0.0383064 |
| CSTB | cystatin B (stefin B) | -0.0370735 |
| SUCNR1 | succinate receptor 1 | -0.0366821 |
| ACTG1 | actin gamma 1 | -0.0364456 |
| HLA-B | major histocompatibility complex, class I, B | -0.0363506 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0345558 |
| EHBP1 | EH domain binding protein 1 | -0.0335312 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0312407 |
| TMSB4X | thymosin beta 4, X-linked | -0.0293437 |
| CANX | calnexin | -0.0275953 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0268593 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0266295 |
| CAVIN1 | caveolae associated protein 1 | -0.0240687 |
| PTMA | prothymosin, alpha | -0.0236631 |
| STC1 | stanniocalcin 1 | -0.0231467 |
| VCL | vinculin | -0.0227743 |
| RPL35A | ribosomal protein L35a | -0.0223734 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0218434 |
| BPTF | bromodomain PHD finger transcription factor | -0.0215666 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0212867 |
| RRBP1 | ribosome binding protein 1 | -0.0211687 |
| RPLP2 | ribosomal protein, large, P2 | -0.0207041 |
| NPR2 | natriuretic peptide receptor 2 | -0.0205804 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0205765 |
| RPLP1 | ribosomal protein, large, P1 | -0.0201464 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0200447 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0197206 |
| RPS24 | ribosomal protein S24 | -0.019535 |
| H3-3B | H3.3 histone B | -0.0194254 |
| RPLP0 | ribosomal protein, large, P0 | -0.0193479 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0190999 |
| RPS5 | ribosomal protein S5 | -0.0188284 |
| MKI67 | marker of proliferation Ki-67 | -0.018712 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0186392 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0184547 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0183784 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0181009 |
| ARF1 | ADP-ribosylation factor 1 | -0.0180949 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0180558 |
| TUBB | tubulin, beta class I | -0.0177954 |
| TMEM263 | transmembrane protein 263 | -0.0177678 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0174392 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0174146 |
| LMO7 | LIM domain 7 | -0.0174099 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0172768 |
| RPS16 | ribosomal protein S16 | -0.0168921 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.016873 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0168682 |
| GDF15 | growth differentiation factor 15 | -0.0167247 |
| PHTF2 | putative homeodomain transcription factor 2 | -0.0167079 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0164731 |
| THY1 | Thy-1 cell surface antigen | -0.0163998 |
| VMP1 | vacuole membrane protein 1 | -0.0163767 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0163716 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0162888 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0162312 |
| PXDN | peroxidasin | -0.0161721 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.016161 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0160103 |
| RPS21 | ribosomal protein S21 | -0.0159312 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0159293 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0158418 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0158138 |
| S100A9 | S100 calcium binding protein A9 | -0.0157108 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0156947 |
| CDK6 | cyclin-dependent kinase 6 | -0.015677 |
| FUS | FUS RNA binding protein | -0.0155985 |
| RPS15 | ribosomal protein S15 | -0.0155524 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0155506 |
| CENPF | centromere protein F, 350/400kDa | -0.0151848 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0151582 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0151241 |
| TBCA | tubulin folding cofactor A | -0.0151129 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0150392 |
| GPR180 | G protein-coupled receptor 180 | -0.0150044 |
| ODAD2 | outer dynein arm docking complex subunit 2 | -0.0149742 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0147775 |
| CTSD | cathepsin D | -0.0147713 |
| RPL12 | ribosomal protein L12 | -0.0147675 |
| RPS6 | ribosomal protein S6 | -0.0146123 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0142872 |
| RPL34 | ribosomal protein L34 | -0.014277 |
| MTDH | metadherin | -0.0142685 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0142552 |
| MT1X | metallothionein 1X | -0.0140992 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0140686 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0139915 |
| HMGB1 | high mobility group box 1 | -0.0138943 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0136945 |
| ASTN2 | astrotactin 2 | -0.0134469 |
| IER3 | immediate early response 3 | -0.0133721 |
