| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCBP2 | poly(rC) binding protein 2 | 0.158773 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132648 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0938588 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0859162 |
| YAP1 | Yes-associated protein 1 | 0.0833875 |
| CCNL1 | cyclin L1 | 0.0782115 |
| MMP12 | matrix metallopeptidase 12 | 0.0691209 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0681161 |
| HMGA1 | high mobility group AT-hook 1 | 0.0660713 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.065771 |
| POTEF | POTE ankyrin domain family, member F | 0.0647402 |
| VMP1 | vacuole membrane protein 1 | 0.06447 |
| TPM3 | tropomyosin 3 | 0.0619636 |
| CDK17 | cyclin-dependent kinase 17 | 0.059113 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.058737 |
| TMEM41B | transmembrane protein 41B | 0.057508 |
| TXNRD1 | thioredoxin reductase 1 | 0.0543099 |
| UBC | ubiquitin C | 0.0537182 |
| NHSL1 | NHS-like 1 | 0.0536961 |
| TMEM123 | transmembrane protein 123 | 0.0531934 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0530824 |
| XPO1 | exportin 1 | 0.0528555 |
| MED13L | mediator complex subunit 13-like | 0.0505952 |
| PDGFC | platelet derived growth factor C | 0.0486557 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0480254 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0480173 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0479854 |
| CPOX | coproporphyrinogen oxidase | 0.0475587 |
| CLTC | clathrin, heavy chain (Hc) | 0.0475551 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.046624 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0456195 |
| RTN4 | reticulon 4 | 0.0445036 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0444793 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0440875 |
| RPL3 | ribosomal protein L3 | 0.0420208 |
| CALR | calreticulin | 0.0416733 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0403752 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0398784 |
| WDR43 | WD repeat domain 43 | 0.0390568 |
| VCL | vinculin | 0.0382669 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.038138 |
| TUBA1B | tubulin, alpha 1b | 0.0380838 |
| JMJD1C | jumonji domain containing 1C | 0.0375623 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0373065 |
| NUP58 | nucleoporin 58 | 0.0367261 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0366423 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0362577 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0360399 |
| RAB7A | RAB7A, member RAS oncogene family | 0.03592 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358249 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0356886 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0356323 |
| RPS18 | ribosomal protein S18 | 0.0354188 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0352063 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.035146 |
| XPOT | exportin, tRNA | 0.0349199 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0346485 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0346168 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0345039 |
| APP | amyloid beta (A4) precursor protein | 0.0344459 |
| CLDND1 | claudin domain containing 1 | 0.0342722 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.033996 |
| HDGF | hepatoma-derived growth factor | 0.0339848 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0339443 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0338525 |
| ECT2 | epithelial cell transforming 2 | 0.0336977 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0333365 |
| AXIN2 | axin 2 | 0.033289 |
| SETD5 | SET domain containing 5 | 0.0327551 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0327545 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0325806 |
| NLGN1 | neuroligin 1 | 0.0324385 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0319002 |
| HLA-A | major histocompatibility complex, class I, A | 0.0317418 |
| USP34 | ubiquitin specific peptidase 34 | 0.0311106 |
| MCL1 | myeloid cell leukemia 1 | 0.0310632 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0309074 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0308089 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0306184 |
| BCHE | butyrylcholinesterase | 0.0305301 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0304958 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0303382 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0302296 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0301407 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0301107 |
| IPO7 | importin 7 | 0.0300852 |
| MATR3 | matrin 3 | 0.0300812 |
| RRM2 | ribonucleotide reductase M2 | 0.0300221 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0295809 |
| NBAS | neuroblastoma amplified sequence | 0.0295693 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0295614 |
| PGK1 | phosphoglycerate kinase 1 | 0.0294278 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0294129 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0289866 |
| ADAR | adenosine deaminase, RNA-specific | 0.0288929 |
| TNPO1 | transportin 1 | 0.0288531 |
| DIAPH1 | diaphanous-related formin 1 | 0.0285568 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0284115 |
| TENM3 | teneurin transmembrane protein 3 | 0.0279723 |
| DIAPH3 | diaphanous-related formin 3 | 0.0277956 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0974922 |
| FTL | ferritin, light polypeptide | -0.0842798 |
| TMSB10 | thymosin beta 10 | -0.0837361 |
| VIM | vimentin | -0.0831513 |
| PCDH7 | protocadherin 7 | -0.0764718 |
| AREG | amphiregulin | -0.0686814 |
| RPLP1 | ribosomal protein, large, P1 | -0.0664344 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.05849 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0570804 |
| RPS19 | ribosomal protein S19 | -0.0408907 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.040428 |
| ZNF804A | zinc finger protein 804A | -0.0404089 |
| EHBP1 | EH domain binding protein 1 | -0.0400749 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0395743 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0384137 |
| RPL26 | ribosomal protein L26 | -0.0377315 |
| RPL36 | ribosomal protein L36 | -0.03686 |
| RPL12 | ribosomal protein L12 | -0.0337829 |
| HMGA2 | high mobility group AT-hook 2 | -0.0335203 |
| EDN1 | endothelin 1 | -0.0328555 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0319321 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0312686 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.031188 |
| RPS6 | ribosomal protein S6 | -0.030371 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0300546 |
| ZNF638 | zinc finger protein 638 | -0.0299831 |
| RPS27A | ribosomal protein S27a | -0.0295335 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0294996 |
| BPTF | bromodomain PHD finger transcription factor | -0.0292354 |
| RPL8 | ribosomal protein L8 | -0.0289994 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.028875 |
| CAVIN1 | caveolae associated protein 1 | -0.0277155 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0276431 |
| RPL23 | ribosomal protein L23 | -0.0275603 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0264987 |
| CCND1 | cyclin D1 | -0.0256145 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0250393 |
| RPL37A | ribosomal protein L37a | -0.0239097 |
| RPL35A | ribosomal protein L35a | -0.0237775 |
| INTS6 | integrator complex subunit 6 | -0.0232204 |
| LRRC23 | leucine rich repeat containing 23 | -0.0225894 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0223997 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.022335 |
| RACK1 | receptor for activated C kinase 1 | -0.0212168 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0208434 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0208308 |
| R3HDM2 | R3H domain containing 2 | -0.0208018 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0206065 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0204398 |
| YBX3 | Y box binding protein 3 | -0.020435 |
| H1-0 | H1.0 linker histone | -0.0204164 |
| RPL28 | ribosomal protein L28 | -0.0203593 |
| RPS17 | ribosomal protein S17 | -0.020183 |
| AHNAK | AHNAK nucleoprotein | -0.0201697 |
| RPS8 | ribosomal protein S8 | -0.0201591 |
| RPS16 | ribosomal protein S16 | -0.0201299 |
| TBCA | tubulin folding cofactor A | -0.0201188 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0199066 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190647 |
| BRCA1 | breast cancer 1, early onset | -0.0190386 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0187843 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0186486 |
| EXOC4 | exocyst complex component 4 | -0.0185848 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0185764 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0183104 |
| RPS3 | ribosomal protein S3 | -0.0181683 |
| RPS27 | ribosomal protein S27 | -0.0180747 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.017953 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0178833 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0178781 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0178415 |
| NBEAL1 | neurobeachin-like 1 | -0.017829 |
| EXOC6B | exocyst complex component 6B | -0.0178239 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0175077 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0173194 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0172822 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.017237 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0169702 |
| GOLGA4 | golgin A4 | -0.0168936 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0167318 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0166842 |
| DUSP16 | dual specificity phosphatase 16 | -0.0166149 |
| EZR | ezrin | -0.0165764 |
| RPL34 | ribosomal protein L34 | -0.0162803 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0162779 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0162579 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.016159 |
| SRP72 | signal recognition particle 72kDa | -0.0161341 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0160609 |
| NPR2 | natriuretic peptide receptor 2 | -0.0160368 |
| CDK13 | cyclin-dependent kinase 13 | -0.0160267 |
| WWC1 | WW and C2 domain containing 1 | -0.0159229 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.015805 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0156076 |
| RPL27A | ribosomal protein L27a | -0.0155716 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0155479 |
| RPL11 | ribosomal protein L11 | -0.0154931 |
| EFNA5 | ephrin-A5 | -0.0154735 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0151592 |
| HMGB1 | high mobility group box 1 | -0.0151296 |
