Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CSF1 colony stimulating factor 1 (macrophage) 0.138033
CCL2 chemokine (C-C motif) ligand 2 0.110885
NAMPT nicotinamide phosphoribosyltransferase 0.104748
MYH9 myosin, heavy chain 9, non-muscle 0.0986034
ZFP36L1 ZFP36 ring finger protein-like 1 0.0913546
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0886939
NRP2 neuropilin 2 0.0823635
SMAD3 SMAD family member 3 0.0783931
NRIP1 nuclear receptor interacting protein 1 0.0734392
ICAM1 intercellular adhesion molecule 1 0.067071
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0644543
CXCL8 chemokine (C-X-C motif) ligand 8 0.0637302
NFE2L2 nuclear factor, erythroid 2-like 2 0.0615649
EXT1 exostosin glycosyltransferase 1 0.0579601
VCAM1 vascular cell adhesion molecule 1 0.055173
APP amyloid beta (A4) precursor protein 0.0514341
FNDC3B fibronectin type III domain containing 3B 0.0509633
DDIT4 DNA-damage-inducible transcript 4 0.0506454
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0505896
UGCG UDP-glucose ceramide glucosyltransferase 0.0479734
SOD2 superoxide dismutase 2, mitochondrial 0.0457038
G0S2 G0/G1 switch 2 0.0431284
HIPK2 homeodomain interacting protein kinase 2 0.041356
DENND2B DENN domain containing 2B 0.0409718
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0406401
JAK1 Janus kinase 1 0.0396787
ANKRD33B ankyrin repeat domain 33B 0.0386135
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0376857
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0376132
PTPRJ protein tyrosine phosphatase, receptor type, J 0.037589
P3H2 prolyl 3-hydroxylase 2 0.0372688
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0366453
PCBP2 poly(rC) binding protein 2 0.0365942
TGFB2 transforming growth factor, beta 2 0.0362787
TXNRD1 thioredoxin reductase 1 0.0359023
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0357896
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0345535
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0343333
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0331462
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0324105
PAX8 paired box 8 0.0318762
TNIP1 TNFAIP3 interacting protein 1 0.031377
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310848
RNF220 ring finger protein 220 0.0300074
PTBP3 polypyrimidine tract binding protein 3 0.0295665
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0293751
CADM1 cell adhesion molecule 1 0.0286121
COL4A1 collagen, type IV, alpha 1 0.028014
ADAR adenosine deaminase, RNA-specific 0.0278277
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0277828
RPL3 ribosomal protein L3 0.0276035
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0266334
BHLHE40 basic helix-loop-helix family, member e40 0.0259903
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0257636
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0255769
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0251265
ATXN10 ataxin 10 0.0246724
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0246585
PLPP3 phospholipid phosphatase 3 0.0244514
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0244108
CKAP5 cytoskeleton associated protein 5 0.0243537
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0243342
GLS2 glutaminase 2 (liver, mitochondrial) 0.0242471
MARCHF6 membrane associated ring-CH-type finger 6 0.0241143
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0241055
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0240937
BIRC3 baculoviral IAP repeat containing 3 0.0239544
EML4 echinoderm microtubule associated protein like 4 0.0237922
PLK2 polo-like kinase 2 0.0237422
ANKRD10 ankyrin repeat domain 10 0.023634
ARHGAP26 Rho GTPase activating protein 26 0.0233918
TNS3 tensin 3 0.0230859
STOX2 storkhead box 2 0.0230421
ADAM17 ADAM metallopeptidase domain 17 0.0230176
NFIB nuclear factor I/B 0.0225468
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0225126
ZMIZ1 zinc finger, MIZ-type containing 1 0.0224025
SPIDR scaffolding protein involved in DNA repair 0.0223565
PBX1 pre-B-cell leukemia homeobox 1 0.0222402
RIPK4 receptor-interacting serine-threonine kinase 4 0.0220832
NCEH1 neutral cholesterol ester hydrolase 1 0.0219449
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0217686
CXCL2 chemokine (C-X-C motif) ligand 2 0.0217491
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0215454
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0214041
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0213685
ANLN anillin, actin binding protein 0.0213237
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0210828
USP12 ubiquitin specific peptidase 12 0.021001
CCNL1 cyclin L1 0.0209781
TNRC6A trinucleotide repeat containing 6A 0.0206556
ELOVL5 ELOVL fatty acid elongase 5 0.0205718
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0204738
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0203621
ACO1 aconitase 1, soluble 0.0202933
SQSTM1 sequestosome 1 0.0202888
ADM adrenomedullin 0.020243
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0201139
RPS18 ribosomal protein S18 0.019994
OSBPL3 oxysterol binding protein-like 3 0.0198685

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.298052
VIM vimentin -0.181935
FRMD4A FERM domain containing 4A -0.134219
CD44 CD44 molecule (Indian blood group) -0.101092
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.077565
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0735367
NDRG1 N-myc downstream regulated 1 -0.0723236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0644666
EHBP1 EH domain binding protein 1 -0.049753
PDIA3 protein disulfide isomerase family A, member 3 -0.0441313
CTSD cathepsin D -0.0440583
CP ceruloplasmin (ferroxidase) -0.0437723
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0418971
PLIN2 perilipin 2 -0.0418385
RPS6 ribosomal protein S6 -0.0398345
RND3 Rho family GTPase 3 -0.0397634
HLA-B major histocompatibility complex, class I, B -0.038946
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.038544
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0364429
TRAM1 translocation associated membrane protein 1 -0.0363874
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0353687
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0349974
TFPI2 tissue factor pathway inhibitor 2 -0.0344207
MAP1B microtubule-associated protein 1B -0.0342056
NAV2 neuron navigator 2 -0.0341798
ACTG1 actin gamma 1 -0.034023
GOLGB1 golgin B1 -0.0336311
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0334919
BICD1 bicaudal D homolog 1 (Drosophila) -0.0317023
MRPS6 mitochondrial ribosomal protein S6 -0.0310515
FAM107B family with sequence similarity 107, member B -0.0310246
SEC31A SEC31 homolog A (S. cerevisiae) -0.0306484
ARL4C ADP-ribosylation factor-like 4C -0.0305586
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0299407
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0297646
RAB7A RAB7A, member RAS oncogene family -0.0295173
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0294167
PDE4D phosphodiesterase 4D, cAMP-specific -0.0294122
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0284332
SP100 SP100 nuclear antigen -0.028368
AKAP9 A kinase (PRKA) anchor protein 9 -0.0283667
ALCAM activated leukocyte cell adhesion molecule -0.0276012
HSPB1 heat shock 27kDa protein 1 -0.027557
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271631
KPNB1 karyopherin (importin) beta 1 -0.0269786
BNC2 basonuclin 2 -0.0268434
ANXA4 annexin A4 -0.0267126
UBAP2 ubiquitin associated protein 2 -0.0265089
HM13 histocompatibility (minor) 13 -0.026229
DST dystonin -0.0261993
MYADM myeloid-associated differentiation marker -0.0259287
HDAC9 histone deacetylase 9 -0.0258714
TPM4 tropomyosin 4 -0.0257877
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0256492
MTDH metadherin -0.0254473
PRKCA protein kinase C, alpha -0.0252867
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0252631
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0250103
MON2 MON2 homolog (S. cerevisiae) -0.0249969
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0249563
BLZF1 basic leucine zipper nuclear factor 1 -0.0249439
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0247465
ZBTB20 zinc finger and BTB domain containing 20 -0.0246514
RPS8 ribosomal protein S8 -0.0244043
CANX calnexin -0.0239167
EIF1 eukaryotic translation initiation factor 1 -0.0238255
EFNA5 ephrin-A5 -0.0237185
TSHZ2 teashirt zinc finger homeobox 2 -0.0237111
CAV1 caveolin 1, caveolae protein, 22kDa -0.0235049
FRMD5 FERM domain containing 5 -0.0233264
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0232126
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0231876
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0228763
DPYSL3 dihydropyrimidinase-like 3 -0.0228621
TPM1 tropomyosin 1 (alpha) -0.0227771
TMSB10 thymosin beta 10 -0.0225811
RPL35A ribosomal protein L35a -0.0224003
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0223118
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.021872
GDI2 GDP dissociation inhibitor 2 -0.0217005
TTC3 tetratricopeptide repeat domain 3 -0.0216924
CDCP1 CUB domain containing protein 1 -0.0216085
RIGI RNA sensor RIG-I -0.0215302
IARS1 isoleucyl-tRNA synthetase 1 -0.021516
RB1 retinoblastoma 1 -0.0213078
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0211587
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0211097
PFN1 profilin 1 -0.0207084
INTS6 integrator complex subunit 6 -0.0205498
IFI16 interferon, gamma-inducible protein 16 -0.0204488
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0202417
PXDN peroxidasin -0.0202142
TUBA1B tubulin, alpha 1b -0.020202
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0201333
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.020114
CHD9 chromodomain helicase DNA binding protein 9 -0.0199857
OXR1 oxidation resistance 1 -0.0197576
TPT1 tumor protein, translationally-controlled 1 -0.0195337
CCND1 cyclin D1 -0.0194824
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0192785