| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.26429 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.162877 |
| SMAD3 | SMAD family member 3 | 0.146133 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.117078 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.104535 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0975563 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0902611 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0807865 |
| PCBP2 | poly(rC) binding protein 2 | 0.073809 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0717017 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0686434 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0674522 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0595052 |
| MCL1 | myeloid cell leukemia 1 | 0.0569366 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0550113 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0529708 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0526788 |
| PGK1 | phosphoglycerate kinase 1 | 0.0513772 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0503535 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0501438 |
| RAI14 | retinoic acid induced 14 | 0.0497051 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0493539 |
| EREG | epiregulin | 0.0473786 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0472427 |
| PDE10A | phosphodiesterase 10A | 0.042593 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0410269 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0403264 |
| EXT1 | exostosin glycosyltransferase 1 | 0.038336 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0380855 |
| RPL3 | ribosomal protein L3 | 0.0380467 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0365331 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0364541 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0363265 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0361874 |
| LDHA | lactate dehydrogenase A | 0.0354586 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0351827 |
| FMNL2 | formin-like 2 | 0.0347706 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0346546 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0344264 |
| MYO1B | myosin IB | 0.0335513 |
| ADAR | adenosine deaminase, RNA-specific | 0.0334216 |
| RPS18 | ribosomal protein S18 | 0.0327696 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0309754 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0309653 |
| APP | amyloid beta (A4) precursor protein | 0.0304494 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0294571 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0292994 |
| FLNB | filamin B, beta | 0.0292631 |
| TNS1 | tensin 1 | 0.0291678 |
| AUTS2 | autism susceptibility candidate 2 | 0.0288392 |
| HIP1 | huntingtin interacting protein 1 | 0.0282992 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0282599 |
| NRG1 | neuregulin 1 | 0.0280458 |
| LOXL2 | lysyl oxidase-like 2 | 0.0278174 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.027367 |
| EFNA5 | ephrin-A5 | 0.0273659 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.027032 |
| RPS3 | ribosomal protein S3 | 0.0265674 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0265109 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0262624 |
| KLF6 | Kruppel-like factor 6 | 0.0262164 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0262026 |
| ANGPTL4 | angiopoietin-like 4 | 0.0257112 |
| WNT7B | wingless-type MMTV integration site family, member 7B | 0.0254677 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0253297 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0250017 |
| RNF145 | ring finger protein 145 | 0.024916 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0247383 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0244672 |
| SEPTIN9 | septin 9 | 0.0243741 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0243174 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0241752 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.024092 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0239646 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0239184 |
| ASPH | aspartate beta-hydroxylase | 0.0239107 |
| ENO1 | enolase 1, (alpha) | 0.0237202 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0237122 |
| MYOF | myoferlin | 0.0236473 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0236322 |
| PDE8A | phosphodiesterase 8A | 0.0235309 |
| FA2H | fatty acid 2-hydroxylase | 0.0230643 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0229411 |
| TGM2 | transglutaminase 2 | 0.0228674 |
| GPRIN3 | GPRIN family member 3 | 0.0227097 |
| KIF16B | kinesin family member 16B | 0.0226474 |
| HDLBP | high density lipoprotein binding protein | 0.0221457 |
| PFKP | phosphofructokinase, platelet | 0.02201 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0217989 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0217844 |
| RARB | retinoic acid receptor, beta | 0.0212255 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0212057 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0211701 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0208295 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0205057 |
| MSN | moesin | 0.0204068 |
| AFDN | afadin, adherens junction formation factor | 0.0202808 |
| RHCG | Rh family, C glycoprotein | 0.0202778 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0201286 |
| ITGB5 | integrin, beta 5 | 0.0200678 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.214015 |
| ACTG1 | actin gamma 1 | -0.100534 |
| VIM | vimentin | -0.082179 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0777373 |
| FTL | ferritin, light polypeptide | -0.0580587 |
| PFN1 | profilin 1 | -0.0450531 |
| RPS6 | ribosomal protein S6 | -0.0447611 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.040542 |
| KRT81 | keratin 81, type II | -0.040274 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0384904 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0367313 |
| TMSB10 | thymosin beta 10 | -0.0358937 |
| NDRG1 | N-myc downstream regulated 1 | -0.0350928 |
| CD44 | CD44 molecule (Indian blood group) | -0.0341988 |
| RPS16 | ribosomal protein S16 | -0.0329396 |
| RPS8 | ribosomal protein S8 | -0.0311668 |
| RPS24 | ribosomal protein S24 | -0.0295159 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0293849 |
| MT1X | metallothionein 1X | -0.0278172 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0277077 |
| RPLP1 | ribosomal protein, large, P1 | -0.0276973 |
| S100A10 | S100 calcium binding protein A10 | -0.0272266 |
| RPS19 | ribosomal protein S19 | -0.0269498 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0253715 |
| USP15 | ubiquitin specific peptidase 15 | -0.0240481 |
| SEPTIN7 | septin 7 | -0.0240374 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0236901 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0232789 |
| RPL8 | ribosomal protein L8 | -0.0230621 |
| JMJD1C | jumonji domain containing 1C | -0.0215898 |
| RPS5 | ribosomal protein S5 | -0.0209698 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0207373 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0205326 |
| ANXA2 | annexin A2 | -0.0202305 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0193953 |
| RPLP0 | ribosomal protein, large, P0 | -0.0193762 |
| ZNF207 | zinc finger protein 207 | -0.0191549 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0190978 |
| RPL19 | ribosomal protein L19 | -0.0189893 |
| RND3 | Rho family GTPase 3 | -0.0188076 |
| DENND4A | DENN/MADD domain containing 4A | -0.0186229 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0184146 |
| RPS13 | ribosomal protein S13 | -0.0184084 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.018392 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0182224 |
| RPL35A | ribosomal protein L35a | -0.0180884 |
| ERBIN | erbb2 interacting protein | -0.0180521 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0177145 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0175926 |
| ASTN2 | astrotactin 2 | -0.017585 |
| IER3 | immediate early response 3 | -0.0173451 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0173056 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0172613 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.01678 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0165193 |
| OXSR1 | oxidative stress responsive 1 | -0.0163311 |
| RPL28 | ribosomal protein L28 | -0.0162029 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0161444 |
| MAP7 | microtubule-associated protein 7 | -0.01614 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0160528 |
| MT2A | metallothionein 2A | -0.0159032 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0158171 |
| ANXA4 | annexin A4 | -0.015638 |
| FBXO11 | F-box protein 11 | -0.0152832 |
| NABP1 | nucleic acid binding protein 1 | -0.0152036 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0151903 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0149591 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0149532 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0149162 |
| RPL7A | ribosomal protein L7a | -0.0148835 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0145905 |
| RPS20 | ribosomal protein S20 | -0.0141373 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0140937 |
| RPS11 | ribosomal protein S11 | -0.0140858 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0140095 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0138916 |
| RPL39 | ribosomal protein L39 | -0.013879 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0138002 |
| CEP350 | centrosomal protein 350kDa | -0.0137536 |
| EGR1 | early growth response 1 | -0.0136437 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0134237 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0133154 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.013087 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0130499 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0130453 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0130346 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0130278 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0130004 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0129271 |
| GOLGB1 | golgin B1 | -0.012926 |
| PYGL | phosphorylase, glycogen, liver | -0.0128511 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0127465 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0127109 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.012685 |
| CAPNS1 | calpain, small subunit 1 | -0.0126689 |
| TBCA | tubulin folding cofactor A | -0.0124569 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.0124456 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0124262 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0123838 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0123675 |
