| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | 0.126762 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0851641 |
| PCBP2 | poly(rC) binding protein 2 | 0.0803076 |
| TXNRD1 | thioredoxin reductase 1 | 0.0801218 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0689018 |
| FLNB | filamin B, beta | 0.067455 |
| PLEC | plectin | 0.0650292 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0607727 |
| PARD3 | par-3 family cell polarity regulator | 0.0600256 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0552629 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0552187 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0539105 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0534694 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0527305 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0522117 |
| HPCAL1 | hippocalcin-like 1 | 0.0494678 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0491637 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0491503 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0479194 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.047751 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0466269 |
| TPM3 | tropomyosin 3 | 0.045054 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0444317 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0436821 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0433734 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0431009 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0410252 |
| UBC | ubiquitin C | 0.040324 |
| ATP13A3 | ATPase type 13A3 | 0.0395817 |
| HMGA1 | high mobility group AT-hook 1 | 0.0380828 |
| SMAD3 | SMAD family member 3 | 0.0380079 |
| USP3 | ubiquitin specific peptidase 3 | 0.0379659 |
| NDRG1 | N-myc downstream regulated 1 | 0.0365174 |
| XPO1 | exportin 1 | 0.035983 |
| SQSTM1 | sequestosome 1 | 0.035973 |
| NPTN | neuroplastin | 0.0349137 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0341901 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.034189 |
| NUP58 | nucleoporin 58 | 0.0338763 |
| FMNL2 | formin-like 2 | 0.0337744 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0333631 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0329696 |
| ZNF292 | zinc finger protein 292 | 0.0325774 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.032519 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0322766 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0320247 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.031865 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0313871 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0313178 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0311163 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0302547 |
| GDA | guanine deaminase | 0.0302369 |
| MED13L | mediator complex subunit 13-like | 0.0297829 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.029106 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0289515 |
| PGK1 | phosphoglycerate kinase 1 | 0.0286345 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0280887 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0279858 |
| NCKAP1 | NCK-associated protein 1 | 0.0278488 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0274968 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0269422 |
| NEK7 | NIMA-related kinase 7 | 0.0268848 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.026873 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.026837 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0264113 |
| SPAG9 | sperm associated antigen 9 | 0.0263992 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0261769 |
| SLMAP | sarcolemma associated protein | 0.0261632 |
| APP | amyloid beta (A4) precursor protein | 0.0261501 |
| PTK2 | protein tyrosine kinase 2 | 0.0259897 |
| RPS18 | ribosomal protein S18 | 0.0258741 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0251826 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.025028 |
| RPL3 | ribosomal protein L3 | 0.0250033 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0247747 |
| YAP1 | Yes-associated protein 1 | 0.0247373 |
| RASA3 | RAS p21 protein activator 3 | 0.0246206 |
| CORO1C | coronin, actin binding protein, 1C | 0.024447 |
| OLA1 | Obg-like ATPase 1 | 0.024174 |
| ABHD17C | abhydrolase domain containing 17C | 0.0239986 |
| QKI | QKI, KH domain containing, RNA binding | 0.0239594 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0239388 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0239176 |
| SERTAD2 | SERTA domain containing 2 | 0.02353 |
| KCMF1 | potassium channel modulatory factor 1 | 0.023528 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0232378 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0230724 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0229011 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0226571 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0226509 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0226009 |
| RCOR1 | REST corepressor 1 | 0.0225143 |
| ACVR1 | activin A receptor, type I | 0.022479 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0224375 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0223368 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0220206 |
| FAM107B | family with sequence similarity 107, member B | 0.0219013 |
| RREB1 | ras responsive element binding protein 1 | 0.0218941 |
| CD164 | CD164 molecule, sialomucin | 0.02189 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0218842 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.138528 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.107199 |
| LAMB3 | laminin, beta 3 | -0.104089 |
| EGFR | epidermal growth factor receptor | -0.0920019 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0856038 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0839057 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.081697 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0795455 |
| LMO7 | LIM domain 7 | -0.0749784 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0743597 |
| LAMA4 | laminin, alpha 4 | -0.0702154 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0694687 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0643408 |
| EFNA5 | ephrin-A5 | -0.0609999 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0605103 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0602701 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.059759 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0593354 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0545829 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0543453 |
| VIM | vimentin | -0.0524793 |
| NPSR1 | neuropeptide S receptor 1 | -0.0523142 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0516057 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0514864 |
| TAOK3 | TAO kinase 3 | -0.051064 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0502263 |
| PRSS3 | protease, serine, 3 | -0.046241 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0441278 |
| RASAL2 | RAS protein activator like 2 | -0.0439303 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0431959 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0422137 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0407434 |
| EHBP1 | EH domain binding protein 1 | -0.0400074 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0392147 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0387317 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0378933 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0365571 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.035994 |
| PMM2 | phosphomannomutase 2 | -0.0347577 |
| HMGA2 | high mobility group AT-hook 2 | -0.03466 |
| DSG2 | desmoglein 2 | -0.034646 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0345323 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0343725 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0337761 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0332386 |
| PRELID2 | PRELI domain containing 2 | -0.0331081 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0324195 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0322108 |
| S100A4 | S100 calcium binding protein A4 | -0.0321993 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0321649 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313951 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0313368 |
| FBXO11 | F-box protein 11 | -0.0312619 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.031145 |
| GOLGB1 | golgin B1 | -0.0304334 |
| PERP | PERP, TP53 apoptosis effector | -0.0303387 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0301252 |
| EMP1 | epithelial membrane protein 1 | -0.029522 |
| RRBP1 | ribosome binding protein 1 | -0.0289904 |
| HDLBP | high density lipoprotein binding protein | -0.0288004 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0286751 |
| CDK13 | cyclin-dependent kinase 13 | -0.0285363 |
| NBEAL1 | neurobeachin-like 1 | -0.0284613 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0284475 |
| VCL | vinculin | -0.028323 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0276654 |
| MUC17 | mucin 17, cell surface associated | -0.02756 |
| KLF6 | Kruppel-like factor 6 | -0.027538 |
| EGR1 | early growth response 1 | -0.0274206 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0271826 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0270007 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.02664 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0264944 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0262786 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0260925 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0260418 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.025988 |
| SVIL | supervillin | -0.0258458 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0256084 |
| MYOF | myoferlin | -0.0253753 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0253022 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0249169 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.024686 |
| GOLGA4 | golgin A4 | -0.0246169 |
| ARF4 | ADP-ribosylation factor 4 | -0.0243264 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.024316 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0241006 |
| RIGI | RNA sensor RIG-I | -0.0237705 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0236896 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.02332 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.023221 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0226571 |
| FOXP2 | forkhead box P2 | -0.0225814 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0223839 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0223504 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0223488 |
| GDI2 | GDP dissociation inhibitor 2 | -0.0223193 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0220846 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0220757 |
| RPL37A | ribosomal protein L37a | -0.0220353 |
