| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.126615 |
| RPL23 | ribosomal protein L23 | 0.116025 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.107079 |
| CEP250 | centrosomal protein 250kDa | 0.0985258 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0900823 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0760144 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0735776 |
| PCBP2 | poly(rC) binding protein 2 | 0.072906 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.072304 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0641354 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.063273 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0627944 |
| TMEM123 | transmembrane protein 123 | 0.0608519 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.055862 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.052643 |
| MCL1 | myeloid cell leukemia 1 | 0.0515256 |
| MSI2 | musashi RNA-binding protein 2 | 0.0491985 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0487837 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0484692 |
| ENO1 | enolase 1, (alpha) | 0.0472693 |
| PGK1 | phosphoglycerate kinase 1 | 0.0429206 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0416675 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0412369 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0411054 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0409276 |
| RPS18 | ribosomal protein S18 | 0.0397786 |
| RPS3 | ribosomal protein S3 | 0.0397034 |
| DHFR | dihydrofolate reductase | 0.0389024 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0386397 |
| TPM3 | tropomyosin 3 | 0.0379715 |
| FDPS | farnesyl diphosphate synthase | 0.0375721 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0372196 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0362769 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0361966 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0354235 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0353809 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0353305 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0352125 |
| LDHA | lactate dehydrogenase A | 0.0337842 |
| EFNA1 | ephrin-A1 | 0.033605 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0329572 |
| CD46 | CD46 molecule, complement regulatory protein | 0.03263 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0315854 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0311952 |
| GNAS | GNAS complex locus | 0.0311551 |
| PTMA | prothymosin, alpha | 0.0311275 |
| KIF16B | kinesin family member 16B | 0.0309097 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0305758 |
| PFKP | phosphofructokinase, platelet | 0.0300635 |
| CD164 | CD164 molecule, sialomucin | 0.0297912 |
| ZFP36 | ZFP36 ring finger protein | 0.0296596 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0292764 |
| FAM13A | family with sequence similarity 13, member A | 0.0292471 |
| CCNY | cyclin Y | 0.0288321 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.02823 |
| MLPH | melanophilin | 0.0275968 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0273162 |
| CALR | calreticulin | 0.0269369 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0265781 |
| RPL3 | ribosomal protein L3 | 0.0265471 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.026529 |
| KRT8 | keratin 8, type II | 0.0263615 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0262515 |
| FADS2 | fatty acid desaturase 2 | 0.026202 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0261887 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0259157 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0258651 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0257255 |
| SQSTM1 | sequestosome 1 | 0.0256311 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0252083 |
| BRD4 | bromodomain containing 4 | 0.0251393 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0249498 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.024793 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0247339 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0240554 |
| ECE1 | endothelin converting enzyme 1 | 0.0238319 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0233704 |
| PCGF2 | polycomb group ring finger 2 | 0.0227729 |
| DSCAM | Down syndrome cell adhesion molecule | 0.021862 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0214054 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0213871 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0213189 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0213069 |
| RREB1 | ras responsive element binding protein 1 | 0.0212558 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0212016 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0209344 |
| FASN | fatty acid synthase | 0.0209173 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0208457 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0208205 |
| MVD | mevalonate (diphospho) decarboxylase | 0.0202342 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0201633 |
| S100A14 | S100 calcium binding protein A14 | 0.0201291 |
| SLC12A7 | solute carrier family 12 (potassium/chloride transporter), member 7 | 0.0201134 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0198373 |
| CLIC4 | chloride intracellular channel 4 | 0.0195734 |
| ANXA2 | annexin A2 | 0.0192252 |
| LRRC59 | leucine rich repeat containing 59 | 0.0191324 |
| FOXO3 | forkhead box O3 | 0.0190434 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0189897 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0188681 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126239 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.107772 |
| CLTC | clathrin, heavy chain (Hc) | -0.101521 |
| CDK12 | cyclin-dependent kinase 12 | -0.0879895 |
| MT2A | metallothionein 2A | -0.0602464 |
| SMYD3 | SET and MYND domain containing 3 | -0.0591568 |
| ACTG1 | actin gamma 1 | -0.0581674 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0568672 |
| ASPH | aspartate beta-hydroxylase | -0.0566988 |
| S100A9 | S100 calcium binding protein A9 | -0.0554909 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0550377 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0546949 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0545384 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0543771 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0529912 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0523092 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0505202 |
| S100A8 | S100 calcium binding protein A8 | -0.0500991 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0489068 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.047498 |
| TXNRD1 | thioredoxin reductase 1 | -0.0472495 |
| JMJD1C | jumonji domain containing 1C | -0.0465397 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0452032 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0437688 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.043698 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0424999 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0421301 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0408896 |
| NTN4 | netrin 4 | -0.0394755 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0394111 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0393937 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0379636 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0377315 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.034333 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0339409 |
| FNBP1 | formin binding protein 1 | -0.0331312 |
| TC2N | tandem C2 domains, nuclear | -0.0324557 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0316273 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | -0.0314175 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0313624 |
| AHR | aryl hydrocarbon receptor | -0.0313389 |
| RPL19 | ribosomal protein L19 | -0.031062 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0307183 |
| SLFN5 | schlafen family member 5 | -0.0305939 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0300815 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0299786 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0297238 |
| MYO1D | myosin ID | -0.0295385 |
| TMSB4X | thymosin beta 4, X-linked | -0.0293671 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0292547 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0292477 |
| MYO1B | myosin IB | -0.0291825 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0291694 |
| GLCCI1 | glucocorticoid induced 1 | -0.0290193 |
| AREG | amphiregulin | -0.0288819 |
| ZNF217 | zinc finger protein 217 | -0.0287884 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0287589 |
| STK17A | serine/threonine kinase 17a | -0.0285776 |
| ANKRD36C | ankyrin repeat domain 36C | -0.028264 |
| RGS6 | regulator of G-protein signaling 6 | -0.0282441 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0282132 |
| CCNI | cyclin I | -0.0280864 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0280645 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0279222 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | -0.0279119 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0278804 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0278145 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0276946 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0274358 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0267267 |
| NABP1 | nucleic acid binding protein 1 | -0.026224 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0261596 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0261416 |
| MED13 | mediator complex subunit 13 | -0.025985 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0258231 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0248937 |
| VMP1 | vacuole membrane protein 1 | -0.0247667 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0247484 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0246834 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.0246077 |
| EGFR | epidermal growth factor receptor | -0.0245737 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -0.02446 |
| TRIM37 | tripartite motif containing 37 | -0.024318 |
| LMO7 | LIM domain 7 | -0.0242609 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0241669 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0239308 |
| NRP1 | neuropilin 1 | -0.0235094 |
| TMC5 | transmembrane channel-like 5 | -0.0234284 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0234047 |
| BPTF | bromodomain PHD finger transcription factor | -0.0233786 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0232849 |
| PTK2 | protein tyrosine kinase 2 | -0.0231641 |
| MAP7 | microtubule-associated protein 7 | -0.0226801 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.022603 |
| CAB39 | calcium binding protein 39 | -0.0222828 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0222248 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0221948 |
| LAMA4 | laminin, alpha 4 | -0.0219661 |
| SNX6 | sorting nexin 6 | -0.0219225 |
| PFDN4 | prefoldin subunit 4 | -0.0219169 |
