Dapagliflozin ((2S)-1,2-propanediol, hydrate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0720794
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0695768
NUP58 nucleoporin 58 0.0682588
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0641301
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.062721
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.061605
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0584876
ATRN attractin 0.0509709
KMT2C lysine (K)-specific methyltransferase 2C 0.048906
FMNL2 formin-like 2 0.0444789
HELZ helicase with zinc finger 0.0444068
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0403413
KDM3A lysine (K)-specific demethylase 3A 0.0386479
JARID2 jumonji, AT rich interactive domain 2 0.0359121
RPS18 ribosomal protein S18 0.0343919
TPD52 tumor protein D52 0.0331084
PCBP2 poly(rC) binding protein 2 0.032125
CDC73 cell division cycle 73 0.0313837
SREBF2 sterol regulatory element binding transcription factor 2 0.0313061
KDM6A lysine (K)-specific demethylase 6A 0.0310604
PIAS2 protein inhibitor of activated STAT, 2 0.0309909
RPL3 ribosomal protein L3 0.0298413
CABIN1 calcineurin binding protein 1 0.029577
CASC3 cancer susceptibility candidate 3 0.0288106
EPN2 epsin 2 0.0284412
CHD7 chromodomain helicase DNA binding protein 7 0.0278842
SEC63 SEC63 homolog (S. cerevisiae) 0.0274496
EFNA5 ephrin-A5 0.0272316
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0266463
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0250072
PUM2 pumilio RNA-binding family member 2 0.0248635
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.024862
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0247673
CHSY1 chondroitin sulfate synthase 1 0.0246812
DHFR dihydrofolate reductase 0.0243065
FAT1 FAT atypical cadherin 1 0.0242884
SSBP2 single-stranded DNA binding protein 2 0.0241233
BRD4 bromodomain containing 4 0.0239341
KDM1A lysine (K)-specific demethylase 1A 0.0239101
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0237093
TENT4A terminal nucleotidyltransferase 4A 0.0236089
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0229748
TET2 tet methylcytosine dioxygenase 2 0.0229368
QKI QKI, KH domain containing, RNA binding 0.0228089
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0227708
CAMTA1 calmodulin binding transcription activator 1 0.0224822
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0224522
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0224384
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0224005
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0221549
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0221219
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0221152
TRIO trio Rho guanine nucleotide exchange factor 0.0214858
BIRC6 baculoviral IAP repeat containing 6 0.021452
MXI1 MAX interactor 1, dimerization protein 0.0213949
RNF145 ring finger protein 145 0.021394
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0212337
AUTS2 autism susceptibility candidate 2 0.0211254
KDM7A lysine (K)-specific demethylase 7A 0.0210129
UBA6 ubiquitin-like modifier activating enzyme 6 0.0209273
MAPT microtubule-associated protein tau 0.0208582
ECPAS Ecm29 proteasome adaptor and scaffold 0.0206837
NPAS3 neuronal PAS domain protein 3 0.0203333
NAMPT nicotinamide phosphoribosyltransferase 0.0203313
LPIN2 lipin 2 0.0202268
PARD3 par-3 family cell polarity regulator 0.0201737
SRSF4 serine/arginine-rich splicing factor 4 0.0199518
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0199457
FAM168A family with sequence similarity 168, member A 0.0199362
ZNF292 zinc finger protein 292 0.0198761
FAM13A family with sequence similarity 13, member A 0.0198148
ARHGAP32 Rho GTPase activating protein 32 0.0196392
SMAP1 small ArfGAP 1 0.0195451
ORC4 origin recognition complex, subunit 4 0.0195006
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0194266
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0194214
TMEM178B transmembrane protein 178B 0.0192287
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0192107
JAM3 junctional adhesion molecule 3 0.0188927
RNF130 ring finger protein 130 0.0188478
USP3 ubiquitin specific peptidase 3 0.0188145
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0187775
USP24 ubiquitin specific peptidase 24 0.0186447
YEATS2 YEATS domain containing 2 0.018563
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.018517
PRRC2A proline-rich coiled-coil 2A 0.0182741
POU2F1 POU class 2 homeobox 1 0.0179539
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0177929
GYS1 glycogen synthase 1 (muscle) 0.0177491
FAM117B family with sequence similarity 117, member B 0.0173879
NKTR natural killer cell triggering receptor 0.0173742
MIDEAS mitotic deacetylase associated SANT domain protein 0.0173062
SRP9 signal recognition particle 9kDa 0.0170853
ADAR adenosine deaminase, RNA-specific 0.0170754
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0169946
HMGA1 high mobility group AT-hook 1 0.0169934
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0169652
MED13L mediator complex subunit 13-like 0.0168849
MAST2 microtubule associated serine/threonine kinase 2 0.0168015
CDYL chromodomain protein, Y-like 0.0167942

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178109
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.1272
TMSB10 thymosin beta 10 -0.100493
SLIT2 slit homolog 2 (Drosophila) -0.0898633
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0860489
ACTG1 actin gamma 1 -0.0833336
RPS8 ribosomal protein S8 -0.0815404
PTMA prothymosin, alpha -0.0804098
TENM3 teneurin transmembrane protein 3 -0.078425
RPL23 ribosomal protein L23 -0.0729992
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0723325
RPS27A ribosomal protein S27a -0.0705363
UBC ubiquitin C -0.0697396
IFI6 interferon, alpha-inducible protein 6 -0.0689828
RPS6 ribosomal protein S6 -0.06808
RPLP1 ribosomal protein, large, P1 -0.0661582
STAT1 signal transducer and activator of transcription 1, 91kDa -0.065324
RPS12 ribosomal protein S12 -0.0645963
RPL26 ribosomal protein L26 -0.0611729
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.061015
RPS3 ribosomal protein S3 -0.0595911
CADM2 cell adhesion molecule 2 -0.0564581
RIGI RNA sensor RIG-I -0.0563007
RPL37A ribosomal protein L37a -0.0543218
RPL12 ribosomal protein L12 -0.049954
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0493163
RPS21 ribosomal protein S21 -0.0490923
ENO1 enolase 1, (alpha) -0.0481302
RPL11 ribosomal protein L11 -0.0480339
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.046577
B2M beta-2-microglobulin -0.0452795
RPL9 ribosomal protein L9 -0.0451538
RPS19 ribosomal protein S19 -0.0450581
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0450348
RPL36 ribosomal protein L36 -0.0449306
RPL28 ribosomal protein L28 -0.0447979
CENPF centromere protein F, 350/400kDa -0.0447704
RPS17 ribosomal protein S17 -0.04458
JUN jun proto-oncogene -0.0442403
RPL19 ribosomal protein L19 -0.0439625
ZNF608 zinc finger protein 608 -0.0438514
SOX4 SRY (sex determining region Y)-box 4 -0.0431115
TPT1 tumor protein, translationally-controlled 1 -0.0418325
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0415003
BPTF bromodomain PHD finger transcription factor -0.0396319
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0390323
VDAC1 voltage-dependent anion channel 1 -0.0382382
RPS4X ribosomal protein S4, X-linked -0.0381941
RPS24 ribosomal protein S24 -0.0370992
HMGB1 high mobility group box 1 -0.0364827
RPL5 ribosomal protein L5 -0.0358148
RPS11 ribosomal protein S11 -0.0351107
RPLP2 ribosomal protein, large, P2 -0.0347032
RPS5 ribosomal protein S5 -0.0346412
SERBP1 SERPINE1 mRNA binding protein 1 -0.0346134
NALF1 NALCN channel auxiliary factor 1 -0.0345002
RPS13 ribosomal protein S13 -0.0342602
RPL34 ribosomal protein L34 -0.0342362
MKI67 marker of proliferation Ki-67 -0.0339223
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0337959
GNAS GNAS complex locus -0.0329989
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0329259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0325879
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0322596
FTL ferritin, light polypeptide -0.0314864
ISG15 ISG15 ubiquitin-like modifier -0.0314294
RPL31 ribosomal protein L31 -0.0312225
RPL32 ribosomal protein L32 -0.0310945
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0310229
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0306642
RPS16 ribosomal protein S16 -0.0305687
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0304517
RPL7A ribosomal protein L7a -0.0302025
VMP1 vacuole membrane protein 1 -0.0296084
MCTP1 multiple C2 domains, transmembrane 1 -0.029143
ZBTB20 zinc finger and BTB domain containing 20 -0.0290562
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0290064
MLIP muscular LMNA-interacting protein -0.0289022
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0288214
FBXL7 F-box and leucine-rich repeat protein 7 -0.0288055
ZNFX1 zinc finger, NFX1-type containing 1 -0.0287433
RBM25 RNA binding motif protein 25 -0.0287006
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0284528
VCL vinculin -0.0283772
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0283712
RPL7 ribosomal protein L7 -0.0282911
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0281207
RACK1 receptor for activated C kinase 1 -0.0279917
RPL18 ribosomal protein L18 -0.027838
RPS15 ribosomal protein S15 -0.0276693
PRICKLE1 prickle homolog 1 (Drosophila) -0.0276009
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0274671
RPL35 ribosomal protein L35 -0.0272718
NBEA neurobeachin -0.0272508
RPS25 ribosomal protein S25 -0.0270557
S100A9 S100 calcium binding protein A9 -0.0270409
RPS14 ribosomal protein S14 -0.0268858
ANKRD17 ankyrin repeat domain 17 -0.0267816
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0261945
RPS29 ribosomal protein S29 -0.0260215