Dapagliflozin ((2S)-1,2-propanediol, hydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.249251
CD109 CD109 molecule 0.110455
NDRG1 N-myc downstream regulated 1 0.0943302
NBAS neuroblastoma amplified sequence 0.0749413
PDIA4 protein disulfide isomerase family A, member 4 0.0738072
KMT2C lysine (K)-specific methyltransferase 2C 0.0732482
NAMPT nicotinamide phosphoribosyltransferase 0.0691582
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0680377
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0680266
ESYT2 extended synaptotagmin-like protein 2 0.067932
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.067269
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0639762
FMNL2 formin-like 2 0.0614412
COPA coatomer protein complex, subunit alpha 0.0609402
TAC4 tachykinin 4 (hemokinin) 0.059844
PHF21A PHD finger protein 21A 0.05822
TMEM178B transmembrane protein 178B 0.0571993
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0569429
TIMP3 TIMP metallopeptidase inhibitor 3 0.052724
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0526134
ENO1 enolase 1, (alpha) 0.0524007
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0520288
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0502178
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0493926
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0486696
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0479872
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0479103
LEF1 lymphoid enhancer-binding factor 1 0.0471144
VGF VGF nerve growth factor inducible 0.0466784
NUP58 nucleoporin 58 0.0462519
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.04459
IGF1R insulin-like growth factor 1 receptor 0.0444143
RNF145 ring finger protein 145 0.0429987
CALR calreticulin 0.0427301
CABIN1 calcineurin binding protein 1 0.0424285
CDC73 cell division cycle 73 0.0420324
CHSY1 chondroitin sulfate synthase 1 0.0418387
RPL3 ribosomal protein L3 0.0418312
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0416879
SSBP3 single stranded DNA binding protein 3 0.0415619
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0412965
FBXO7 F-box protein 7 0.040733
EXT1 exostosin glycosyltransferase 1 0.0398823
MEF2A myocyte enhancer factor 2A 0.0397704
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0396152
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0394911
FNDC3B fibronectin type III domain containing 3B 0.0392452
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.039009
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0388823
PTK2 protein tyrosine kinase 2 0.038393
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0381076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380247
UBE2H ubiquitin-conjugating enzyme E2H 0.0373612
MACF1 microtubule-actin crosslinking factor 1 0.0365239
APP amyloid beta (A4) precursor protein 0.0360911
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0358
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0356979
SND1 staphylococcal nuclease and tudor domain containing 1 0.0354612
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0347397
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0347172
PCBP2 poly(rC) binding protein 2 0.0345749
PGK1 phosphoglycerate kinase 1 0.0336008
MIDEAS mitotic deacetylase associated SANT domain protein 0.033564
CTBP2 C-terminal binding protein 2 0.0333523
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0330775
FRMD6 FERM domain containing 6 0.0328149
EGLN1 egl-9 family hypoxia-inducible factor 1 0.032788
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0326849
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0326498
ZNF292 zinc finger protein 292 0.0322251
CADM1 cell adhesion molecule 1 0.0321789
RNF213 ring finger protein 213 0.0320036
NHSL1 NHS-like 1 0.0318029
KMT2E lysine (K)-specific methyltransferase 2E 0.031376
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0312433
ZYX zyxin 0.0312062
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0311895
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0310971
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0309933
CALU calumenin 0.0308868
TRIM2 tripartite motif containing 2 0.0308687
SOX5 SRY (sex determining region Y)-box 5 0.0307731
ASPH aspartate beta-hydroxylase 0.0307025
SETD5 SET domain containing 5 0.0301636
UBC ubiquitin C 0.0300266
UBA6 ubiquitin-like modifier activating enzyme 6 0.0297645
TMEM123 transmembrane protein 123 0.0293259
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.02888
AFDN afadin, adherens junction formation factor 0.0283614
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0282304
C10ORF90 chromosome 10 open reading frame 90 0.0282015
UBASH3B ubiquitin associated and SH3 domain containing B 0.0280346
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0279666
RNF24 ring finger protein 24 0.027778
MRTFA myocardin related transcription factor A 0.0277735
PTPRM protein tyrosine phosphatase, receptor type, M 0.027484
KDM6A lysine (K)-specific demethylase 6A 0.0269763
ZNF704 zinc finger protein 704 0.0267751
TNIK TRAF2 and NCK interacting kinase 0.0266544
ADM adrenomedullin 0.0265166

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.240075
VIM vimentin -0.12715
IFI16 interferon, gamma-inducible protein 16 -0.0872659
MT2A metallothionein 2A -0.0824775
TMSB10 thymosin beta 10 -0.0676349
FMN1 formin 1 -0.0667184
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0664745
ACTG1 actin gamma 1 -0.0633038
GPC6 glypican 6 -0.0631517
RPLP1 ribosomal protein, large, P1 -0.0566432
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0525438
IER3 immediate early response 3 -0.0481222
RPL37A ribosomal protein L37a -0.043737
HLA-B major histocompatibility complex, class I, B -0.0430223
TNNC1 troponin C type 1 (slow) -0.042153
TPT1 tumor protein, translationally-controlled 1 -0.0386515
RPL35A ribosomal protein L35a -0.0354978
FTL ferritin, light polypeptide -0.0347364
LOC112694756 uncharaterized LOC112694756 -0.0337711
TM4SF1 transmembrane 4 L six family member 1 -0.0334928
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.033482
RPS19 ribosomal protein S19 -0.033335
PCDH7 protocadherin 7 -0.0297204
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0295253
RPS8 ribosomal protein S8 -0.0286178
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0279886
RPS12 ribosomal protein S12 -0.0276357
PTCHD4 patched domain containing 4 -0.0274905
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0269845
S100A9 S100 calcium binding protein A9 -0.0261938
RPL30 ribosomal protein L30 -0.0249402
EGR1 early growth response 1 -0.0244825
NLGN1 neuroligin 1 -0.0241711
MT1X metallothionein 1X -0.0239352
CD63 CD63 molecule -0.0239183
RPL26 ribosomal protein L26 -0.0235907
RPL12 ribosomal protein L12 -0.0235734
MACROD2 MACRO domain containing 2 -0.0225435
HMGA2 high mobility group AT-hook 2 -0.0222044
OSMR oncostatin M receptor -0.0221648
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0220482
FUS FUS RNA binding protein -0.021603
S100A6 S100 calcium binding protein A6 -0.0208151
RPL11 ribosomal protein L11 -0.0200263
WSB1 WD repeat and SOCS box containing 1 -0.0198146
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0195622
TPI1 triosephosphate isomerase 1 -0.0195537
IFITM3 interferon induced transmembrane protein 3 -0.0193939
NCOA7 nuclear receptor coactivator 7 -0.0190535
RPL36 ribosomal protein L36 -0.018742
RPL19 ribosomal protein L19 -0.0187016
RPLP0 ribosomal protein, large, P0 -0.0185956
RPS6 ribosomal protein S6 -0.0185117
RRBP1 ribosome binding protein 1 -0.018396
RPS3 ribosomal protein S3 -0.0183065
ITGB8 integrin, beta 8 -0.018278
VDAC1 voltage-dependent anion channel 1 -0.0181696
RPS24 ribosomal protein S24 -0.0180384
RPL23 ribosomal protein L23 -0.0176335
RPL34 ribosomal protein L34 -0.0174442
RPLP2 ribosomal protein, large, P2 -0.0174123
RPS29 ribosomal protein S29 -0.0173831
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.017371
RPL7 ribosomal protein L7 -0.0169868
RPL9 ribosomal protein L9 -0.016924
RPS20 ribosomal protein S20 -0.0168813
RPL37 ribosomal protein L37 -0.0167651
MBD5 methyl-CpG binding domain protein 5 -0.0167201
HMGB1 high mobility group box 1 -0.0165381
LOC102724023 ES1 protein homolog, mitochondrial -0.0162495
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.016177
RPL27A ribosomal protein L27a -0.0161062
RPS21 ribosomal protein S21 -0.0159668
IFITM2 interferon induced transmembrane protein 2 -0.0159033
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0158846
MCTP1 multiple C2 domains, transmembrane 1 -0.0157704
BACE2 beta-site APP-cleaving enzyme 2 -0.0156524
RPS11 ribosomal protein S11 -0.0154549
RPS4X ribosomal protein S4, X-linked -0.0154197
INPP5F inositol polyphosphate-5-phosphatase F -0.0153823
GNAS GNAS complex locus -0.0153575
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0152203
SPTSSA serine palmitoyltransferase, small subunit A -0.0151481
EIF1 eukaryotic translation initiation factor 1 -0.0150745
VCL vinculin -0.0149885
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0149166
JMJD1C jumonji domain containing 1C -0.0148605
RPS2 ribosomal protein S2 -0.0147926
COL19A1 collagen, type XIX, alpha 1 -0.0147063
CDH19 cadherin 19, type 2 -0.0146703
BZW1 basic leucine zipper and W2 domains 1 -0.0146675
S100A10 S100 calcium binding protein A10 -0.0144642
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.014449
RPS27A ribosomal protein S27a -0.0143536
RPL8 ribosomal protein L8 -0.0142896
LMNA lamin A/C -0.0142808
TRRAP transformation/transcription domain-associated protein -0.0141035
SHROOM4 shroom family member 4 -0.0137743
FRMD4A FERM domain containing 4A -0.0137733
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0133292