| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.0920936 |
| NDRG1 | N-myc downstream regulated 1 | 0.0820375 |
| SMAD3 | SMAD family member 3 | 0.072096 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0634189 |
| MCL1 | myeloid cell leukemia 1 | 0.0609242 |
| PCBP2 | poly(rC) binding protein 2 | 0.0583237 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0571647 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0535516 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0521329 |
| APOL1 | apolipoprotein L, 1 | 0.0495417 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0471656 |
| RAD51B | RAD51 paralog B | 0.0455371 |
| CCNY | cyclin Y | 0.0448583 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0424461 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0411157 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0407578 |
| MEF2A | myocyte enhancer factor 2A | 0.0396431 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0379157 |
| TPM3 | tropomyosin 3 | 0.0354459 |
| RPS18 | ribosomal protein S18 | 0.0345884 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.0342827 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0328273 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0323923 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0320678 |
| RPL3 | ribosomal protein L3 | 0.031375 |
| MT2A | metallothionein 2A | 0.0309938 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0307695 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0291194 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0289483 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.028668 |
| GRB10 | growth factor receptor-bound protein 10 | 0.027958 |
| HPCAL1 | hippocalcin-like 1 | 0.0277249 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0271173 |
| APP | amyloid beta (A4) precursor protein | 0.0269774 |
| ZNF395 | zinc finger protein 395 | 0.0263675 |
| MUC4 | mucin 4, cell surface associated | 0.0261918 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0259758 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0258485 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0258281 |
| PARD3 | par-3 family cell polarity regulator | 0.0256755 |
| C3 | complement component 3 | 0.0256427 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0256085 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0253059 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0252149 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0248715 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0248479 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0246456 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0245458 |
| ENO1 | enolase 1, (alpha) | 0.0238905 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0237131 |
| RNF149 | ring finger protein 149 | 0.0232854 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0230786 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0228511 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0226162 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0225516 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0224983 |
| TMEM51 | transmembrane protein 51 | 0.0223898 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.022365 |
| TGM2 | transglutaminase 2 | 0.0222436 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0221021 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.022037 |
| ANXA11 | annexin A11 | 0.021931 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0218044 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0218034 |
| MSN | moesin | 0.0217215 |
| NUP58 | nucleoporin 58 | 0.0216253 |
| DNMBP | dynamin binding protein | 0.0214029 |
| PLAUR | plasminogen activator, urokinase receptor | 0.021059 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0210254 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0207889 |
| RCOR1 | REST corepressor 1 | 0.0203365 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0201755 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0201551 |
| AGRN | agrin | 0.0196325 |
| ABI1 | abl-interactor 1 | 0.0194246 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0192746 |
| INSIG2 | insulin induced gene 2 | 0.0190055 |
| RNASET2 | ribonuclease T2 | 0.0189635 |
| TFG | TRK-fused gene | 0.0189268 |
| ACTN1 | actinin, alpha 1 | 0.0187627 |
| AFAP1 | actin filament associated protein 1 | 0.0187537 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0186037 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0184968 |
| PLAT | plasminogen activator, tissue | 0.0183461 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0183173 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.018216 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0181684 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0181231 |
| CMIP | c-Maf inducing protein | 0.0180304 |
| SEPTIN9 | septin 9 | 0.0179794 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.017968 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0176617 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0176472 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0176364 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.017544 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0175114 |
| PLEC | plectin | 0.0174829 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0174362 |
| PFKP | phosphofructokinase, platelet | 0.0174331 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0168745 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.229737 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.140737 |
| TMSB10 | thymosin beta 10 | -0.124066 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.108689 |
| ANXA2 | annexin A2 | -0.099005 |
| TMSB4X | thymosin beta 4, X-linked | -0.0989823 |
| PTMA | prothymosin, alpha | -0.0924342 |
| ACTG1 | actin gamma 1 | -0.0883077 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0867108 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0702527 |
| VIM | vimentin | -0.069939 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0655202 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0636668 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0608732 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0597877 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0520872 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0517136 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0514912 |
| IER3 | immediate early response 3 | -0.049743 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0491925 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0489172 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0488791 |
| FTL | ferritin, light polypeptide | -0.0481809 |
| LMO7 | LIM domain 7 | -0.0469174 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0461897 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0458946 |
| S100A6 | S100 calcium binding protein A6 | -0.0447094 |
| MYO1E | myosin IE | -0.0443195 |
| MT1X | metallothionein 1X | -0.0433965 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0430815 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0418244 |
| S100A10 | S100 calcium binding protein A10 | -0.0416285 |
| RPLP0 | ribosomal protein, large, P0 | -0.0410055 |
| RPLP1 | ribosomal protein, large, P1 | -0.0391269 |
| PLAU | plasminogen activator, urokinase | -0.0375646 |
| UBC | ubiquitin C | -0.0373779 |
| JMJD1C | jumonji domain containing 1C | -0.0367273 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0365127 |
| H1-0 | H1.0 linker histone | -0.0362285 |
| MORF4L2 | mortality factor 4 like 2 | -0.0359894 |
| SYNRG | synergin, gamma | -0.0359055 |
| MMP7 | matrix metallopeptidase 7 | -0.0357171 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0348169 |
| TSC22D2 | TSC22 domain family, member 2 | -0.034319 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0343064 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0339497 |
| RPL19 | ribosomal protein L19 | -0.033843 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0332719 |
| RTN3 | reticulon 3 | -0.03278 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0326574 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0325593 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0324974 |
| RPS8 | ribosomal protein S8 | -0.0320612 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0320303 |
| ARF1 | ADP-ribosylation factor 1 | -0.0318437 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0317631 |
| RBM39 | RNA binding motif protein 39 | -0.0313867 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0311053 |
| EZR | ezrin | -0.0306892 |
| GNAS | GNAS complex locus | -0.0305233 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0299543 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0297652 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0295491 |
| RLF | rearranged L-myc fusion | -0.0294202 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0293676 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.029192 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0290388 |
| BICC1 | BicC family RNA binding protein 1 | -0.0286983 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0283294 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0276799 |
| RPS24 | ribosomal protein S24 | -0.027423 |
| FOXO3 | forkhead box O3 | -0.0272507 |
| NABP1 | nucleic acid binding protein 1 | -0.0270759 |
| RPL34 | ribosomal protein L34 | -0.0269142 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0267192 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0263159 |
| RPL35A | ribosomal protein L35a | -0.0261992 |
| RUNX1 | runt-related transcription factor 1 | -0.0261518 |
| BRD2 | bromodomain containing 2 | -0.0260964 |
| CP | ceruloplasmin (ferroxidase) | -0.0259952 |
| EMP1 | epithelial membrane protein 1 | -0.02594 |
| RPL23 | ribosomal protein L23 | -0.0257441 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0254304 |
| FBXO11 | F-box protein 11 | -0.0253065 |
| MED13 | mediator complex subunit 13 | -0.0252605 |
| MICU1 | mitochondrial calcium uptake 1 | -0.0251975 |
| RPL8 | ribosomal protein L8 | -0.0251365 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0251162 |
| HLA-E | major histocompatibility complex, class I, E | -0.0250916 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0247237 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0246844 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0246761 |
| RACK1 | receptor for activated C kinase 1 | -0.0246424 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0245846 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0241554 |
| HBP1 | HMG-box transcription factor 1 | -0.0239133 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0238777 |
| DSG2 | desmoglein 2 | -0.0236246 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0236089 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0236035 |
