| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.134938 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0825076 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0688408 |
| RUNX1 | runt-related transcription factor 1 | 0.0642813 |
| RNF149 | ring finger protein 149 | 0.0641348 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0639614 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0612629 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0606256 |
| TXNIP | thioredoxin interacting protein | 0.0538848 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.043706 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0436395 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0433212 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0422851 |
| FNIP1 | folliculin interacting protein 1 | 0.0404351 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0398916 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0395705 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0393801 |
| YEATS2 | YEATS domain containing 2 | 0.0393734 |
| PCBP2 | poly(rC) binding protein 2 | 0.0392056 |
| ATXN1 | ataxin 1 | 0.0374049 |
| PTEN | phosphatase and tensin homolog | 0.0367867 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0364937 |
| CANX | calnexin | 0.0364604 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0357185 |
| SBF2 | SET binding factor 2 | 0.0355952 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0354929 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.035159 |
| DNM2 | dynamin 2 | 0.0345575 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0342064 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0324536 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0323973 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0318415 |
| PDS5B | PDS5 cohesin associated factor B | 0.0310087 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0309 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0304933 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0297154 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0296319 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0295038 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.029044 |
| SEC24D | SEC24 family member D | 0.0288092 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0288001 |
| UBAC2 | UBA domain containing 2 | 0.0286627 |
| ARRDC3 | arrestin domain containing 3 | 0.0282707 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0281084 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0280943 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0280674 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0275218 |
| HELZ | helicase with zinc finger | 0.0274644 |
| AFF1 | AF4/FMR2 family, member 1 | 0.027255 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0272442 |
| GOLGA4 | golgin A4 | 0.0272353 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0268464 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0266873 |
| HBS1L | HBS1-like translational GTPase | 0.0265609 |
| COG6 | component of oligomeric golgi complex 6 | 0.0265138 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0263579 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0263422 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0263227 |
| CALR | calreticulin | 0.0260957 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0258595 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0256989 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0253659 |
| HYOU1 | hypoxia up-regulated 1 | 0.0253547 |
| MATR3 | matrin 3 | 0.0252301 |
| OGA | O-GlcNAcase | 0.0248035 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0246509 |
| USP3 | ubiquitin specific peptidase 3 | 0.0246063 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0244932 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0243048 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0242829 |
| STK24 | serine/threonine kinase 24 | 0.0242284 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0240166 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0239254 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0239144 |
| GRAMD2B | GRAM domain containing 2B | 0.023672 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0236683 |
| AHI1 | Abelson helper integration site 1 | 0.0236491 |
| RREB1 | ras responsive element binding protein 1 | 0.0236005 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0235427 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0231036 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0230842 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0230708 |
| XPO1 | exportin 1 | 0.0228192 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0226569 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0226004 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.022123 |
| TMEM39A | transmembrane protein 39A | 0.0220791 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0218147 |
| TJP2 | tight junction protein 2 | 0.0218039 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0215863 |
| SFXN1 | sideroflexin 1 | 0.021524 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0215113 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0214728 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0212515 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0212491 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0210803 |
| EHF | ets homologous factor | 0.0208658 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0206755 |
| RNF43 | ring finger protein 43 | 0.0206322 |
| APP | amyloid beta (A4) precursor protein | 0.0203664 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.152069 |
| ANXA2 | annexin A2 | -0.13707 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.134963 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.128284 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.119344 |
| RNF213 | ring finger protein 213 | -0.101586 |
| EGR1 | early growth response 1 | -0.100334 |
| SP100 | SP100 nuclear antigen | -0.0997697 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0997165 |
| RIGI | RNA sensor RIG-I | -0.081617 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.079524 |
| INTS6 | integrator complex subunit 6 | -0.0790116 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0780907 |
| MX2 | MX dynamin-like GTPase 2 | -0.0778766 |
| AREG | amphiregulin | -0.0765044 |
| PERP | PERP, TP53 apoptosis effector | -0.0718155 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0693556 |
| MX1 | MX dynamin-like GTPase 1 | -0.068619 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0677515 |
| ACTG1 | actin gamma 1 | -0.0676554 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0669455 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0643967 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0634425 |
| LAMA4 | laminin, alpha 4 | -0.0597297 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.05943 |
| ERBIN | erbb2 interacting protein | -0.0559343 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0555223 |
| B2M | beta-2-microglobulin | -0.0553151 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0545338 |
| PLSCR2 | phospholipid scramblase 2 | -0.054279 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0537501 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.053278 |
| NPSR1 | neuropeptide S receptor 1 | -0.0521781 |
| VMP1 | vacuole membrane protein 1 | -0.0521129 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0516545 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0507788 |
| XAF1 | XIAP associated factor 1 | -0.0504405 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0498612 |
| PLSCR1 | phospholipid scramblase 1 | -0.0492707 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0482684 |
| TJP1 | tight junction protein 1 | -0.0477864 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0465528 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0411594 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0410712 |
| PMP22 | peripheral myelin protein 22 | -0.0399387 |
| HLA-B | major histocompatibility complex, class I, B | -0.039408 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0391308 |
| LCN2 | lipocalin 2 | -0.0389908 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0389073 |
| PTMA | prothymosin, alpha | -0.0388777 |
| EFNB2 | ephrin-B2 | -0.0383033 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0376778 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0371435 |
| SQSTM1 | sequestosome 1 | -0.036802 |
| NABP1 | nucleic acid binding protein 1 | -0.0367282 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0353111 |
| VCL | vinculin | -0.0348095 |
| TMC5 | transmembrane channel-like 5 | -0.0346446 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0346158 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0343192 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0334161 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0333565 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0328395 |
| FTL | ferritin, light polypeptide | -0.032377 |
| POU2F2 | POU class 2 homeobox 2 | -0.032018 |
| MUC20 | mucin 20, cell surface associated | -0.0318842 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0317188 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0317173 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0316941 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0314761 |
| SDC4 | syndecan 4 | -0.0314697 |
| EZR | ezrin | -0.0308424 |
| UBAP2 | ubiquitin associated protein 2 | -0.0303832 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0296442 |
| MYO1E | myosin IE | -0.0296257 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0291817 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0291643 |
| JUN | jun proto-oncogene | -0.0288573 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0286808 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0286402 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0286292 |
| LAP3 | leucine aminopeptidase 3 | -0.028317 |
| ETV6 | ets variant 6 | -0.0280868 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0278863 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0270159 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0269079 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0267172 |
| ITGA6 | integrin, alpha 6 | -0.0264916 |
| HKDC1 | hexokinase domain containing 1 | -0.0261102 |
| MCL1 | myeloid cell leukemia 1 | -0.0260547 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0259683 |
| POF1B | premature ovarian failure, 1B | -0.0256404 |
| IER3 | immediate early response 3 | -0.0255402 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0254772 |
| FMN1 | formin 1 | -0.0253068 |
| TMSB10 | thymosin beta 10 | -0.0251735 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.025148 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0249151 |
| BCL2L1 | BCL2-like 1 | -0.0248551 |
| IRS2 | insulin receptor substrate 2 | -0.0244345 |
