| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.156465 |
| COL6A3 | collagen, type VI, alpha 3 | 0.106436 |
| FNDC3B | fibronectin type III domain containing 3B | 0.103355 |
| EGFR | epidermal growth factor receptor | 0.0930978 |
| LOXL2 | lysyl oxidase-like 2 | 0.090017 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0888172 |
| PCBP2 | poly(rC) binding protein 2 | 0.0876431 |
| CADM1 | cell adhesion molecule 1 | 0.0766549 |
| COL5A1 | collagen, type V, alpha 1 | 0.0729496 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0724037 |
| EXT1 | exostosin glycosyltransferase 1 | 0.070157 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0701027 |
| MSN | moesin | 0.0692941 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0630364 |
| TNS3 | tensin 3 | 0.0623396 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0575399 |
| TPM3 | tropomyosin 3 | 0.0574753 |
| RPL3 | ribosomal protein L3 | 0.0573055 |
| PKM | pyruvate kinase, muscle | 0.056912 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0568621 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0556124 |
| TPM4 | tropomyosin 4 | 0.0554362 |
| CENPF | centromere protein F, 350/400kDa | 0.0525218 |
| ACTN1 | actinin, alpha 1 | 0.0515784 |
| APP | amyloid beta (A4) precursor protein | 0.0510682 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0482714 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0479365 |
| ATP13A3 | ATPase type 13A3 | 0.045559 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0453828 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0451279 |
| RPS18 | ribosomal protein S18 | 0.0447125 |
| ENO1 | enolase 1, (alpha) | 0.0446728 |
| POTEF | POTE ankyrin domain family, member F | 0.0441079 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0437077 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0431211 |
| VEGFA | vascular endothelial growth factor A | 0.0423299 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0421852 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0420485 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0419431 |
| CALR | calreticulin | 0.0417928 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0411631 |
| MYO1B | myosin IB | 0.0407279 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0405249 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0402982 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0402651 |
| MYOF | myoferlin | 0.0400525 |
| NAV2 | neuron navigator 2 | 0.0396331 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0395671 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0394732 |
| AXL | AXL receptor tyrosine kinase | 0.0384854 |
| SEPTIN9 | septin 9 | 0.0378517 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.037589 |
| MCL1 | myeloid cell leukemia 1 | 0.0369383 |
| SMAD3 | SMAD family member 3 | 0.0368651 |
| HLA-A | major histocompatibility complex, class I, A | 0.0357641 |
| YEATS2 | YEATS domain containing 2 | 0.035701 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0353905 |
| B2M | beta-2-microglobulin | 0.0353088 |
| CORO1C | coronin, actin binding protein, 1C | 0.0349852 |
| COG5 | component of oligomeric golgi complex 5 | 0.0346268 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0340426 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0340202 |
| FAM219A | family with sequence similarity 219, member A | 0.033892 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0338127 |
| FLNA | filamin A, alpha | 0.0335907 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0335527 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0332041 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0329243 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0323555 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0323086 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0318078 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0316412 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0300815 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0300639 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0298434 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0294806 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0294581 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0293132 |
| SEC24A | SEC24 family member A | 0.0290897 |
| KYNU | kynureninase | 0.0286795 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0286603 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0284762 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0284221 |
| LDHA | lactate dehydrogenase A | 0.0281844 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0280479 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0280416 |
| STC2 | stanniocalcin 2 | 0.0280173 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0278424 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0278029 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0276838 |
| SRP54 | signal recognition particle 54kDa | 0.0276798 |
| YBX1 | Y box binding protein 1 | 0.0276375 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.0275905 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.027246 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0272313 |
| MB21D2 | Mab-21 domain containing 2 | 0.0270144 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0269899 |
| TMEM39A | transmembrane protein 39A | 0.0269745 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0269484 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0268972 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.334408 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.219295 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.101677 |
| TMSB10 | thymosin beta 10 | -0.0835755 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0643679 |
| CD44 | CD44 molecule (Indian blood group) | -0.0608927 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0603637 |
| RPLP1 | ribosomal protein, large, P1 | -0.0583717 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0579627 |
| ASPH | aspartate beta-hydroxylase | -0.055501 |
| DST | dystonin | -0.0499595 |
| HLA-B | major histocompatibility complex, class I, B | -0.046928 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0461574 |
| RPL28 | ribosomal protein L28 | -0.04551 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0449464 |
| VIM | vimentin | -0.0448683 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0425625 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0422 |
| FN1 | fibronectin 1 | -0.0383629 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0383032 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0360062 |
| S100A10 | S100 calcium binding protein A10 | -0.0355699 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0353243 |
| RPL34 | ribosomal protein L34 | -0.0353046 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0348618 |
| RPLP0 | ribosomal protein, large, P0 | -0.0342672 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0342184 |
| AUTS2 | autism susceptibility candidate 2 | -0.0335639 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | -0.0331113 |
| EMP1 | epithelial membrane protein 1 | -0.0328855 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0326235 |
| MT2A | metallothionein 2A | -0.0325996 |
| RPS6 | ribosomal protein S6 | -0.0322315 |
| TNNC1 | troponin C type 1 (slow) | -0.0315976 |
| PTCHD4 | patched domain containing 4 | -0.0312171 |
| CALN1 | calneuron 1 | -0.0311419 |
| FUS | FUS RNA binding protein | -0.0309365 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0303925 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0287713 |
| RRBP1 | ribosome binding protein 1 | -0.0284877 |
| NLGN1 | neuroligin 1 | -0.0284191 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0279077 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0278233 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.027125 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.026883 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0268391 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0260461 |
| OSMR | oncostatin M receptor | -0.0256809 |
| RPS8 | ribosomal protein S8 | -0.0255906 |
| RPS24 | ribosomal protein S24 | -0.0254912 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0254439 |
| RPL12 | ribosomal protein L12 | -0.0250538 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0250029 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0249838 |
| STK17A | serine/threonine kinase 17a | -0.0246297 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0246008 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.0244289 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0244038 |
| RPL19 | ribosomal protein L19 | -0.0243217 |
| ARF1 | ADP-ribosylation factor 1 | -0.0242414 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0236701 |
| TPTE | transmembrane phosphatase with tensin homology | -0.0233891 |
| RPLP2 | ribosomal protein, large, P2 | -0.0233606 |
| FTL | ferritin, light polypeptide | -0.0232374 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.022838 |
| RPL35A | ribosomal protein L35a | -0.0226686 |
| S100A6 | S100 calcium binding protein A6 | -0.0225675 |
| CANX | calnexin | -0.0225577 |
| GPHN | gephyrin | -0.0225363 |
| DTNA | dystrobrevin, alpha | -0.0224025 |
| RPL27A | ribosomal protein L27a | -0.0223094 |
| HMGA2 | high mobility group AT-hook 2 | -0.0222072 |
| ANXA2 | annexin A2 | -0.0221836 |
| GLCCI1 | glucocorticoid induced 1 | -0.0220498 |
| RPS27A | ribosomal protein S27a | -0.0219719 |
| SUMF1 | sulfatase modifying factor 1 | -0.021829 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0217759 |
| H3-3B | H3.3 histone B | -0.0216645 |
| MORF4L1 | mortality factor 4 like 1 | -0.0216585 |
| NCOA7 | nuclear receptor coactivator 7 | -0.02153 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0215273 |
| S100A9 | S100 calcium binding protein A9 | -0.0214472 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213763 |
| TMEM263 | transmembrane protein 263 | -0.0213583 |
| RACK1 | receptor for activated C kinase 1 | -0.0213349 |
| AOPEP | aminopeptidase O (putative) | -0.0212711 |
| RPS16 | ribosomal protein S16 | -0.0211843 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0211121 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0208053 |
| RPL37A | ribosomal protein L37a | -0.0206958 |
| SEC61G | Sec61 gamma subunit | -0.0205984 |
| RPL23 | ribosomal protein L23 | -0.020513 |
| EHBP1 | EH domain binding protein 1 | -0.0203487 |
| TUBB | tubulin, beta class I | -0.0203466 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.020058 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.0200294 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0199216 |
| LOX | lysyl oxidase | -0.0198853 |
| PTMA | prothymosin, alpha | -0.0198315 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0196518 |
