Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.208769
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.19192
AHNAK AHNAK nucleoprotein 0.136858
FAT1 FAT atypical cadherin 1 0.131809
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.124241
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.094873
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0948632
PCBP2 poly(rC) binding protein 2 0.0947387
DSCAM Down syndrome cell adhesion molecule 0.0892263
ENO1 enolase 1, (alpha) 0.0890742
ERRFI1 ERBB receptor feedback inhibitor 1 0.0835606
MYH9 myosin, heavy chain 9, non-muscle 0.0815895
NDRG1 N-myc downstream regulated 1 0.0809866
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0722892
PGK1 phosphoglycerate kinase 1 0.0703605
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0697576
TXNRD1 thioredoxin reductase 1 0.069021
CANX calnexin 0.0636254
GOLGA4 golgin A4 0.0627634
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0612216
PRELID2 PRELI domain containing 2 0.0577347
MED13L mediator complex subunit 13-like 0.0571211
SETD5 SET domain containing 5 0.0559712
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0558784
TPM4 tropomyosin 4 0.0555188
ZNF292 zinc finger protein 292 0.0553956
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0553688
CTNND1 catenin (cadherin-associated protein), delta 1 0.0548718
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0539622
LDHA lactate dehydrogenase A 0.0524337
KRT18 keratin 18, type I 0.0523563
COPB1 coatomer protein complex, subunit beta 1 0.0522338
ZFAND3 zinc finger, AN1-type domain 3 0.0522062
RBM39 RNA binding motif protein 39 0.0511729
ANKRD11 ankyrin repeat domain 11 0.0495205
TM9SF3 transmembrane 9 superfamily member 3 0.0480912
GARS1 glycyl-tRNA synthetase 1 0.047272
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.046789
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0465187
TBC1D22A TBC1 domain family, member 22A 0.0464072
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.04544
PLAUR plasminogen activator, urokinase receptor 0.0452838
HELZ helicase with zinc finger 0.0450295
CLTC clathrin, heavy chain (Hc) 0.0440972
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.043545
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0430497
COPA coatomer protein complex, subunit alpha 0.0426057
IARS1 isoleucyl-tRNA synthetase 1 0.0425018
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0423943
DLG1 discs, large homolog 1 (Drosophila) 0.0423472
APP amyloid beta (A4) precursor protein 0.0423445
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0422144
KMT2C lysine (K)-specific methyltransferase 2C 0.041971
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0417893
RAB1A RAB1A, member RAS oncogene family 0.0417521
YME1L1 YME1-like 1 ATPase 0.0414994
RLF rearranged L-myc fusion 0.041362
FNDC3B fibronectin type III domain containing 3B 0.0412514
PDIA3 protein disulfide isomerase family A, member 3 0.0412087
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.041181
EEF2 eukaryotic translation elongation factor 2 0.0408683
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.040406
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0404018
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0403419
UBA6 ubiquitin-like modifier activating enzyme 6 0.0402067
PTMA prothymosin, alpha 0.0399055
SEC31A SEC31 homolog A (S. cerevisiae) 0.0397283
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0395862
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0388271
BBX bobby sox homolog (Drosophila) 0.0385515
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0384799
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0383381
MARCHF6 membrane associated ring-CH-type finger 6 0.038091
MCL1 myeloid cell leukemia 1 0.0380172
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0378689
USP34 ubiquitin specific peptidase 34 0.0378277
SUCO SUN domain containing ossification factor 0.0376757
GOLGB1 golgin B1 0.0376706
NUP58 nucleoporin 58 0.0375693
BIRC6 baculoviral IAP repeat containing 6 0.0375034
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0369051
OGA O-GlcNAcase 0.0367258
FDPS farnesyl diphosphate synthase 0.0366932
SEC24D SEC24 family member D 0.036651
FHIT fragile histidine triad 0.0365891
HOOK2 hook microtubule-tethering protein 2 0.0364162
DSPP dentin sialophosphoprotein 0.0360758
PUM1 pumilio RNA-binding family member 1 0.0357781
LPP LIM domain containing preferred translocation partner in lipoma 0.0354238
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0352878
RAD51B RAD51 paralog B 0.0351864
YEATS2 YEATS domain containing 2 0.0350536
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0349365
NF1 neurofibromin 1 0.0346832
RPL3 ribosomal protein L3 0.0346569
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0344256
MATR3 matrin 3 0.034403
WDR45B WD repeat domain 45B 0.0343015
INSIG2 insulin induced gene 2 0.0342978
WAC WW domain containing adaptor with coiled-coil 0.0340484

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0875485
FTL ferritin, light polypeptide -0.0654237
MT2A metallothionein 2A -0.0612854
TMSB10 thymosin beta 10 -0.0552611
RPLP1 ribosomal protein, large, P1 -0.0442553
RPS19 ribosomal protein S19 -0.0425193
RPS6 ribosomal protein S6 -0.0419107
RPL35A ribosomal protein L35a -0.0411569
RPS8 ribosomal protein S8 -0.0397815
EGR1 early growth response 1 -0.0365683
RPL36 ribosomal protein L36 -0.0343402
INTS6 integrator complex subunit 6 -0.0339501
RPL26 ribosomal protein L26 -0.030196
LOC112694756 uncharaterized LOC112694756 -0.0286314
RPL37A ribosomal protein L37a -0.0285662
RPS3 ribosomal protein S3 -0.0281218
MIDN midnolin -0.0277631
RPL34 ribosomal protein L34 -0.0257982
RPS27 ribosomal protein S27 -0.0256522
RPS29 ribosomal protein S29 -0.0255519
RPLP2 ribosomal protein, large, P2 -0.0253439
RPL5 ribosomal protein L5 -0.0251572
RPS12 ribosomal protein S12 -0.0244926
RPS17 ribosomal protein S17 -0.022633
RPL12 ribosomal protein L12 -0.0200305
RPL9 ribosomal protein L9 -0.0181694
RPL28 ribosomal protein L28 -0.0180727
RPL27 ribosomal protein L27 -0.0178591
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0177785
CEMIP2 cell migration inducing hyaluronidase 2 -0.0173966
RPL13A ribosomal protein L13a -0.0173231
RPL23 ribosomal protein L23 -0.0171937
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0167363
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0160954
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0157137
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0157005
RPS15 ribosomal protein S15 -0.0155766
LRRC23 leucine rich repeat containing 23 -0.0153789
UQCRB ubiquinol-cytochrome c reductase binding protein -0.015103
LOC102724023 ES1 protein homolog, mitochondrial -0.0147796
NABP1 nucleic acid binding protein 1 -0.0144586
PCDH7 protocadherin 7 -0.01438
RPL31 ribosomal protein L31 -0.0141707
SRSF11 serine/arginine-rich splicing factor 11 -0.01393
RPL35 ribosomal protein L35 -0.0139294
FN1 fibronectin 1 -0.0139042
RPS25 ribosomal protein S25 -0.0135452
ACTG1 actin gamma 1 -0.013377
COX5A cytochrome c oxidase subunit Va -0.013246
RPS21 ribosomal protein S21 -0.0131306
RPS27A ribosomal protein S27a -0.0129879
RPL7A ribosomal protein L7a -0.0128391
RPL18 ribosomal protein L18 -0.0128261
RPL19 ribosomal protein L19 -0.0125961
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0125612
PHF14 PHD finger protein 14 -0.0124996
PDE4D phosphodiesterase 4D, cAMP-specific -0.0124298
SLC38A2 solute carrier family 38, member 2 -0.0123773
GPX4 glutathione peroxidase 4 -0.0123733
RPS4X ribosomal protein S4, X-linked -0.0123378
POU2F2 POU class 2 homeobox 2 -0.011901
PRH1 proline-rich protein HaeIII subfamily 1 -0.0118007
RPS16 ribosomal protein S16 -0.0117781
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -0.011599
HLA-B major histocompatibility complex, class I, B -0.0115314
SEC61G Sec61 gamma subunit -0.0115163
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0114856
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.0114635
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.011305
BZW2 basic leucine zipper and W2 domains 2 -0.0110329
SPDYA speedy/RINGO cell cycle regulator family member A -0.0110156
TGFB1 transforming growth factor, beta 1 -0.0109715
RPS20 ribosomal protein S20 -0.0109407
POLN polymerase (DNA directed) nu -0.0109248
SCAPER S-phase cyclin A-associated protein in the ER -0.0108959
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.0108685
TUBB4B tubulin, beta 4B class IVb -0.0107291
MRPS6 mitochondrial ribosomal protein S6 -0.0106014
KDM3B lysine (K)-specific demethylase 3B -0.0104749
RPL37 ribosomal protein L37 -0.0104656
PRDX2 peroxiredoxin 2 -0.0104588
FGF18 fibroblast growth factor 18 -0.0104539
RPS10 ribosomal protein S10 -0.0102344
STC1 stanniocalcin 1 -0.0101531
NSUN6 NOP2/Sun domain family, member 6 -0.0101451
S100A10 S100 calcium binding protein A10 -0.0101147
GPC5 glypican 5 -0.010102
RPL30 ribosomal protein L30 -0.0100002
EPAS1 endothelial PAS domain protein 1 -0.00996684
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.00992265
TPT1 tumor protein, translationally-controlled 1 -0.00987132
STPG4 sperm-tail PG-rich repeat containing 4 -0.00986944
RPS14 ribosomal protein S14 -0.0098673
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.00977282
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0097414
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.00974028
ANKMY1 ankyrin repeat and MYND domain containing 1 -0.0096192
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00961822
PFN1 profilin 1 -0.00957023
VIM vimentin -0.0095023