| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.101209 |
| APP | amyloid beta (A4) precursor protein | 0.062076 |
| PCBP2 | poly(rC) binding protein 2 | 0.0600604 |
| RNF145 | ring finger protein 145 | 0.0537611 |
| ZNF292 | zinc finger protein 292 | 0.0479604 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0474697 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0469112 |
| MATR3 | matrin 3 | 0.0460316 |
| SMAD3 | SMAD family member 3 | 0.0429156 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0419623 |
| SNX9 | sorting nexin 9 | 0.0403154 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0380045 |
| HELZ | helicase with zinc finger | 0.0379819 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0364834 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0362051 |
| RPL3 | ribosomal protein L3 | 0.0341691 |
| NCKAP1 | NCK-associated protein 1 | 0.033424 |
| POTEF | POTE ankyrin domain family, member F | 0.0329225 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.032232 |
| TFG | TRK-fused gene | 0.032103 |
| FNBP1L | formin binding protein 1-like | 0.0317649 |
| SETD5 | SET domain containing 5 | 0.0316992 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0312083 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0310956 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0309104 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0307579 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0304643 |
| OGA | O-GlcNAcase | 0.0287623 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.028535 |
| NUP58 | nucleoporin 58 | 0.0284744 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0283916 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0280785 |
| CCNL1 | cyclin L1 | 0.027543 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0273775 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0270805 |
| PGK1 | phosphoglycerate kinase 1 | 0.0270337 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0266854 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0263792 |
| RLF | rearranged L-myc fusion | 0.0263318 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0260673 |
| CDC73 | cell division cycle 73 | 0.0257382 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.025554 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0255386 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.025474 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0254495 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0254372 |
| TPM3 | tropomyosin 3 | 0.0253295 |
| PLEC | plectin | 0.0249391 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0248874 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0247606 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0244427 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0243272 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0243135 |
| GOLGA4 | golgin A4 | 0.0242614 |
| RPS18 | ribosomal protein S18 | 0.0239921 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0239573 |
| SPOPL | speckle-type POZ protein-like | 0.0238156 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0237331 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0237326 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0237316 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0236301 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0235051 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0232843 |
| ZNF148 | zinc finger protein 148 | 0.022682 |
| USP3 | ubiquitin specific peptidase 3 | 0.0223876 |
| AFDN | afadin, adherens junction formation factor | 0.0220697 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0219927 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0219301 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0218936 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0214556 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0212224 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0211935 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.021168 |
| QKI | QKI, KH domain containing, RNA binding | 0.021142 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0211199 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.020972 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0208454 |
| UBC | ubiquitin C | 0.0207733 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0204396 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0201848 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.020118 |
| NEK7 | NIMA-related kinase 7 | 0.0200936 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.019803 |
| SBF2 | SET binding factor 2 | 0.0197495 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0196286 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0196123 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0195658 |
| AXL | AXL receptor tyrosine kinase | 0.0195567 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0194676 |
| ANXA11 | annexin A11 | 0.0194666 |
| UBQLN1 | ubiquilin 1 | 0.0193987 |
| DIAPH1 | diaphanous-related formin 1 | 0.0193926 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0193308 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0193043 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0192764 |
| SCRN1 | secernin 1 | 0.0191897 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0191643 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0190976 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0189671 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0189123 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.165773 |
| TMSB10 | thymosin beta 10 | -0.136533 |
| ASPH | aspartate beta-hydroxylase | -0.116157 |
| MT2A | metallothionein 2A | -0.0870064 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0842024 |
| ACTG1 | actin gamma 1 | -0.0789882 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0710531 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.068535 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0676217 |
| RPS6 | ribosomal protein S6 | -0.0598958 |
| RPL35A | ribosomal protein L35a | -0.058888 |
| HMGA2 | high mobility group AT-hook 2 | -0.0584051 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0528107 |
| SVIL | supervillin | -0.0512226 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0509722 |
| PTMA | prothymosin, alpha | -0.0493355 |
| FTL | ferritin, light polypeptide | -0.0473292 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0467971 |
| RPS8 | ribosomal protein S8 | -0.0454004 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0450666 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0443676 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0436991 |
| BPTF | bromodomain PHD finger transcription factor | -0.0425216 |
| CD44 | CD44 molecule (Indian blood group) | -0.0422119 |
| RPL23 | ribosomal protein L23 | -0.0421761 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0420253 |
| RAD51B | RAD51 paralog B | -0.0406089 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0405346 |
| EGFR | epidermal growth factor receptor | -0.0402043 |
| RPS19 | ribosomal protein S19 | -0.0377636 |
| PRELID2 | PRELI domain containing 2 | -0.0373872 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0372012 |
| RPLP1 | ribosomal protein, large, P1 | -0.0371157 |
| PCED1B | PC-esterase domain containing 1B | -0.0365511 |
| RPL37A | ribosomal protein L37a | -0.0360735 |
| INTS6 | integrator complex subunit 6 | -0.035634 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.035389 |
| EHBP1 | EH domain binding protein 1 | -0.0343165 |
| RPL34 | ribosomal protein L34 | -0.0343108 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0343068 |
| RPL31 | ribosomal protein L31 | -0.0339918 |
| MACROD2 | MACRO domain containing 2 | -0.0337829 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0330802 |
| RPL26 | ribosomal protein L26 | -0.032517 |
| RPL9 | ribosomal protein L9 | -0.0319731 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0317765 |
| AEBP2 | AE binding protein 2 | -0.0317622 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0310847 |
| S100A10 | S100 calcium binding protein A10 | -0.0308732 |
| RPS27A | ribosomal protein S27a | -0.0305353 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0300176 |
| RPL11 | ribosomal protein L11 | -0.0298189 |
| RPS17 | ribosomal protein S17 | -0.0295609 |
| CCDC138 | coiled-coil domain containing 138 | -0.0295335 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0293008 |
| RPL28 | ribosomal protein L28 | -0.029261 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0287632 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0283742 |
| RPS24 | ribosomal protein S24 | -0.0283217 |
| RPL12 | ribosomal protein L12 | -0.0282159 |
| PCNX4 | pecanex 4 | -0.0280502 |
| RPL7A | ribosomal protein L7a | -0.0279276 |
| ITGA6 | integrin, alpha 6 | -0.0271898 |
| CCND1 | cyclin D1 | -0.0269042 |
| TMSB4X | thymosin beta 4, X-linked | -0.0268377 |
| SPATA13 | spermatogenesis associated 13 | -0.0265385 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0264592 |
| RPL19 | ribosomal protein L19 | -0.0263826 |
| LAMA4 | laminin, alpha 4 | -0.0262544 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0261961 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0261203 |
| ATXN1 | ataxin 1 | -0.0254711 |
| FHIT | fragile histidine triad | -0.0252071 |
| VDAC1 | voltage-dependent anion channel 1 | -0.02518 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0248452 |
| DIAPH3 | diaphanous-related formin 3 | -0.0244997 |
| SLC38A2 | solute carrier family 38, member 2 | -0.024432 |
| RPS3 | ribosomal protein S3 | -0.0244305 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0242529 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0241725 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.0240992 |
| PRKCA | protein kinase C, alpha | -0.0240112 |
| HMGB1 | high mobility group box 1 | -0.0239635 |
| S100A9 | S100 calcium binding protein A9 | -0.0238734 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.023529 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0235245 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0233913 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0233316 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0231085 |
| ATG7 | autophagy related 7 | -0.0230862 |
| RACK1 | receptor for activated C kinase 1 | -0.0230854 |
| LASP1 | LIM and SH3 protein 1 | -0.0229707 |
| GPR39 | G protein-coupled receptor 39 | -0.0229115 |
| RPS12 | ribosomal protein S12 | -0.0224756 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0223588 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0222302 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0221648 |
| TBCA | tubulin folding cofactor A | -0.0221463 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0221384 |
| AHNAK | AHNAK nucleoprotein | -0.0221254 |
