| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.155227 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0714632 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0624707 |
| SMAD3 | SMAD family member 3 | 0.0591272 |
| SEPTIN9 | septin 9 | 0.0560631 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0537788 |
| MCL1 | myeloid cell leukemia 1 | 0.0466357 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0466208 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0460677 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0444373 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0426054 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0419183 |
| AXL | AXL receptor tyrosine kinase | 0.040176 |
| PCBP2 | poly(rC) binding protein 2 | 0.039007 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0385994 |
| MT2A | metallothionein 2A | 0.0379984 |
| RRM2 | ribonucleotide reductase M2 | 0.0342489 |
| LOXL2 | lysyl oxidase-like 2 | 0.0337322 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0334746 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0293666 |
| PLEC | plectin | 0.0286477 |
| ADM | adrenomedullin | 0.0284005 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0274787 |
| HPCAL1 | hippocalcin-like 1 | 0.0269675 |
| MSN | moesin | 0.0269445 |
| RPL3 | ribosomal protein L3 | 0.0267222 |
| FAM13A | family with sequence similarity 13, member A | 0.0266889 |
| RPS18 | ribosomal protein S18 | 0.0264689 |
| TAC4 | tachykinin 4 (hemokinin) | 0.026333 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0258644 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0256144 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0250829 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0246405 |
| ATP13A3 | ATPase type 13A3 | 0.0245446 |
| FOSL1 | FOS-like antigen 1 | 0.0228931 |
| LDHA | lactate dehydrogenase A | 0.022555 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0220158 |
| NAV2 | neuron navigator 2 | 0.0216549 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0208251 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0202924 |
| CENPF | centromere protein F, 350/400kDa | 0.0202395 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0200811 |
| TPM3 | tropomyosin 3 | 0.0199805 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0199593 |
| FLNA | filamin A, alpha | 0.019891 |
| SYAP1 | synapse associated protein 1 | 0.0196761 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0196348 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0189201 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0186764 |
| MLPH | melanophilin | 0.0184163 |
| TNS1 | tensin 1 | 0.0183906 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0183355 |
| HJURP | Holliday junction recognition protein | 0.0183182 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.018183 |
| RNF220 | ring finger protein 220 | 0.0181572 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0179768 |
| UBC | ubiquitin C | 0.0178588 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0176518 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0175529 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0175286 |
| NUP58 | nucleoporin 58 | 0.0174915 |
| APP | amyloid beta (A4) precursor protein | 0.0168358 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0167742 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0165223 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0163221 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0161871 |
| ZFP36 | ZFP36 ring finger protein | 0.0160896 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0157275 |
| PER1 | period circadian clock 1 | 0.0157101 |
| YBX3 | Y box binding protein 3 | 0.015701 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0156788 |
| YBX1 | Y box binding protein 1 | 0.0156149 |
| CCNL1 | cyclin L1 | 0.0153289 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0151339 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0151118 |
| CORO1C | coronin, actin binding protein, 1C | 0.0148579 |
| CLIC4 | chloride intracellular channel 4 | 0.0147672 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0144322 |
| POTEF | POTE ankyrin domain family, member F | 0.0144257 |
| TFRC | transferrin receptor | 0.0143092 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0141918 |
| MYO1B | myosin IB | 0.0139796 |
| RYBP | RING1 and YY1 binding protein | 0.013823 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0137712 |
| TGM2 | transglutaminase 2 | 0.0136842 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0134097 |
| SYNJ2 | synaptojanin 2 | 0.0133758 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0133721 |
| RASA3 | RAS p21 protein activator 3 | 0.0133691 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0131776 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0131602 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0130511 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0130039 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0129591 |
| AFDN | afadin, adherens junction formation factor | 0.0129532 |
| PFKP | phosphofructokinase, platelet | 0.012906 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0129036 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0127932 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0127157 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0126295 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.304944 |
| VIM | vimentin | -0.261652 |
| HMGA2 | high mobility group AT-hook 2 | -0.183957 |
| IGF2 | insulin-like growth factor 2 | -0.112555 |
| TMSB10 | thymosin beta 10 | -0.105011 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.102661 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0966935 |
| CDH13 | cadherin 13 | -0.0892136 |
| RAI14 | retinoic acid induced 14 | -0.0796077 |
| DST | dystonin | -0.073796 |
| CANX | calnexin | -0.0725293 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.071223 |
| ASPH | aspartate beta-hydroxylase | -0.0682407 |
| LAMB3 | laminin, beta 3 | -0.0664325 |
| LOX | lysyl oxidase | -0.063817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0628252 |
| ACTG1 | actin gamma 1 | -0.0613042 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0547397 |
| AHNAK | AHNAK nucleoprotein | -0.0508 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0494692 |
| COL5A1 | collagen, type V, alpha 1 | -0.0474815 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.046786 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0467751 |
| FMN1 | formin 1 | -0.046469 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0455267 |
| ANXA2 | annexin A2 | -0.0438544 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0424837 |
| NF1 | neurofibromin 1 | -0.0421591 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0420985 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0416941 |
| RRBP1 | ribosome binding protein 1 | -0.0415143 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0407665 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0407057 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0406842 |
| CLMP | CXADR-like membrane protein | -0.0406602 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0399817 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0397644 |
| CAVIN1 | caveolae associated protein 1 | -0.0392649 |
| TNNC1 | troponin C type 1 (slow) | -0.0381653 |
| MYO10 | myosin X | -0.0381635 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0377897 |
| TENM2 | teneurin transmembrane protein 2 | -0.0376234 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0373809 |
| GLIS3 | GLIS family zinc finger 3 | -0.0372413 |
| CD44 | CD44 molecule (Indian blood group) | -0.0365815 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0364521 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0362201 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0361889 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0349848 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0338958 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0336981 |
| JMJD1C | jumonji domain containing 1C | -0.0332249 |
| BPTF | bromodomain PHD finger transcription factor | -0.0329643 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0324506 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0324422 |
| TAOK1 | TAO kinase 1 | -0.0323468 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0322593 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0322501 |
| PRKCA | protein kinase C, alpha | -0.0318009 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0317723 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0315833 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0315666 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0312628 |
| EGFR | epidermal growth factor receptor | -0.0309614 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0309531 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0309217 |
| USP34 | ubiquitin specific peptidase 34 | -0.0307639 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0305766 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0299418 |
| CUX1 | cut-like homeobox 1 | -0.0297726 |
| OGA | O-GlcNAcase | -0.0294599 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029241 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0290138 |
| MYO9A | myosin IXA | -0.028823 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0287973 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0286779 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0283931 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0282009 |
| FRMD4A | FERM domain containing 4A | -0.0276014 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0275105 |
| MAP4 | microtubule-associated protein 4 | -0.0274937 |
| AK1 | adenylate kinase 1 | -0.0272641 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0272158 |
| VCL | vinculin | -0.0271164 |
| COL1A1 | collagen, type I, alpha 1 | -0.0270712 |
| CEP350 | centrosomal protein 350kDa | -0.0269975 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0266562 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0266019 |
| SBF2 | SET binding factor 2 | -0.0262616 |
| GLG1 | golgi glycoprotein 1 | -0.0262067 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0262036 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0261974 |
| PRSS23 | protease, serine, 23 | -0.0261465 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0259166 |
| TMEM165 | transmembrane protein 165 | -0.0258898 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0258572 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.025824 |
| FNIP1 | folliculin interacting protein 1 | -0.0258085 |
| GOLGB1 | golgin B1 | -0.025558 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0252981 |
