| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.293116 |
| LOXL2 | lysyl oxidase-like 2 | 0.151236 |
| ATP13A3 | ATPase type 13A3 | 0.135886 |
| CADM1 | cell adhesion molecule 1 | 0.118957 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0814876 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0765638 |
| SMAD3 | SMAD family member 3 | 0.0718376 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.06656 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0612938 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0555632 |
| VEGFA | vascular endothelial growth factor A | 0.0521833 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0510583 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0502878 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0497495 |
| POSTN | periostin, osteoblast specific factor | 0.0477923 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0471127 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0461889 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0455337 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0453594 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0438473 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0428797 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0425003 |
| SPAG9 | sperm associated antigen 9 | 0.042073 |
| MTSS1 | metastasis suppressor 1 | 0.0405063 |
| ADM | adrenomedullin | 0.0385567 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0355586 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0355141 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0351592 |
| ARRDC3 | arrestin domain containing 3 | 0.0350635 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0340417 |
| ZNF292 | zinc finger protein 292 | 0.0330568 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0327958 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0322419 |
| TPM4 | tropomyosin 4 | 0.0311209 |
| SQLE | squalene epoxidase | 0.0310177 |
| NAV2 | neuron navigator 2 | 0.0305781 |
| FAT1 | FAT atypical cadherin 1 | 0.0298566 |
| RPL3 | ribosomal protein L3 | 0.0296372 |
| SETD5 | SET domain containing 5 | 0.0294727 |
| CD109 | CD109 molecule | 0.0284649 |
| AXL | AXL receptor tyrosine kinase | 0.0275769 |
| RPS18 | ribosomal protein S18 | 0.0270509 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0268814 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0267576 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0263728 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0261414 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0258809 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0257301 |
| ECE1 | endothelin converting enzyme 1 | 0.0256783 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.025494 |
| APP | amyloid beta (A4) precursor protein | 0.0254566 |
| PLEC | plectin | 0.0251694 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0248496 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0245054 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0244447 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0242984 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0242466 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0236091 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.023278 |
| LDHA | lactate dehydrogenase A | 0.02313 |
| AZIN1 | antizyme inhibitor 1 | 0.0230058 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0229606 |
| RNF145 | ring finger protein 145 | 0.0229319 |
| PCBP2 | poly(rC) binding protein 2 | 0.02257 |
| HMGA1 | high mobility group AT-hook 1 | 0.0223096 |
| TRAM2 | translocation associated membrane protein 2 | 0.0221043 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0216366 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0216315 |
| AFAP1 | actin filament associated protein 1 | 0.0215722 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0210162 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0209936 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0207676 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0203005 |
| RASA2 | RAS p21 protein activator 2 | 0.0200512 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0197249 |
| TNS1 | tensin 1 | 0.0194232 |
| USP3 | ubiquitin specific peptidase 3 | 0.0192897 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.0192073 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0188958 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0187995 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0187582 |
| RARB | retinoic acid receptor, beta | 0.0186772 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.0186633 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0185205 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0184254 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0184227 |
| FAM20C | family with sequence similarity 20, member C | 0.0180785 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0180588 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0178308 |
| GATA6 | GATA binding protein 6 | 0.0175966 |
| ADAR | adenosine deaminase, RNA-specific | 0.0174911 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0173598 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0173173 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0171197 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0170016 |
| HLA-A | major histocompatibility complex, class I, A | 0.0169895 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.016796 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0167734 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0167587 |
| MAP1B | microtubule-associated protein 1B | 0.0165946 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.195694 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.183416 |
| COL1A1 | collagen, type I, alpha 1 | -0.180336 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.13258 |
| CDH13 | cadherin 13 | -0.106361 |
| ASPH | aspartate beta-hydroxylase | -0.104808 |
| TMSB10 | thymosin beta 10 | -0.102668 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0819397 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0760422 |
| MT2A | metallothionein 2A | -0.0743878 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0738561 |
| ACTG1 | actin gamma 1 | -0.0668782 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0629222 |
| AHNAK | AHNAK nucleoprotein | -0.0610874 |
| FBN1 | fibrillin 1 | -0.0595681 |
| CALD1 | caldesmon 1 | -0.0583531 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0582884 |
| HMGA2 | high mobility group AT-hook 2 | -0.0575427 |
| GLIS3 | GLIS family zinc finger 3 | -0.0567614 |
| COL5A1 | collagen, type V, alpha 1 | -0.0558452 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0552722 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0549858 |
| RPS8 | ribosomal protein S8 | -0.054882 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0534427 |
| UBC | ubiquitin C | -0.0506685 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0465903 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0436634 |
| RPS27A | ribosomal protein S27a | -0.0435915 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0422299 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0416288 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.040256 |
| VCL | vinculin | -0.0402011 |
| CALU | calumenin | -0.0377782 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0368889 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0362299 |
| RPL26 | ribosomal protein L26 | -0.0355932 |
| FTL | ferritin, light polypeptide | -0.0345221 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0345015 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0344648 |
| GOLGB1 | golgin B1 | -0.034119 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0340245 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0330235 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0328718 |
| CANX | calnexin | -0.0323801 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0320511 |
| CNTN5 | contactin 5 | -0.0318343 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.031729 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0316494 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0315478 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0305232 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0302133 |
| SLC38A2 | solute carrier family 38, member 2 | -0.030046 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0298795 |
| ENO1 | enolase 1, (alpha) | -0.0295913 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0290705 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0289058 |
| CD44 | CD44 molecule (Indian blood group) | -0.028846 |
| EXT1 | exostosin glycosyltransferase 1 | -0.028588 |
| BNC2 | basonuclin 2 | -0.0282783 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0281273 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.027966 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0277914 |
| HDAC9 | histone deacetylase 9 | -0.0275628 |
| SQSTM1 | sequestosome 1 | -0.0273316 |
| RRBP1 | ribosome binding protein 1 | -0.0272008 |
| RPL35A | ribosomal protein L35a | -0.0270351 |
| NABP1 | nucleic acid binding protein 1 | -0.0270018 |
| FOXP1 | forkhead box P1 | -0.0268747 |
| PRKCA | protein kinase C, alpha | -0.0267831 |
| RPL5 | ribosomal protein L5 | -0.0267376 |
| NDRG1 | N-myc downstream regulated 1 | -0.026573 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0265103 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0262959 |
| DST | dystonin | -0.0262658 |
| PTMA | prothymosin, alpha | -0.0262548 |
| INTS6 | integrator complex subunit 6 | -0.0258245 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0257711 |
| OXR1 | oxidation resistance 1 | -0.0256503 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0255422 |
| RPL23 | ribosomal protein L23 | -0.0254541 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0254299 |
| RPS6 | ribosomal protein S6 | -0.0253897 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0253864 |
| RPLP1 | ribosomal protein, large, P1 | -0.0252751 |
| RPL37A | ribosomal protein L37a | -0.0250964 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0248685 |
| CUX1 | cut-like homeobox 1 | -0.0248316 |
| RPS19 | ribosomal protein S19 | -0.02477 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0247427 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0246821 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0245476 |
| NEK10 | NIMA-related kinase 10 | -0.0245222 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0241553 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0238149 |
| RPS3 | ribosomal protein S3 | -0.0236702 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0236301 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0234093 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0232355 |
| MTDH | metadherin | -0.0232182 |
| SUMF1 | sulfatase modifying factor 1 | -0.0230449 |
