Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD12 sterile alpha motif domain containing 12 0.083951
KMT2C lysine (K)-specific methyltransferase 2C 0.0764797
EXT1 exostosin glycosyltransferase 1 0.0695256
KDM6A lysine (K)-specific demethylase 6A 0.0638725
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0600385
FNDC3B fibronectin type III domain containing 3B 0.0596339
PTK2 protein tyrosine kinase 2 0.0585907
RAD21 RAD21 homolog (S. pombe) 0.0581491
SMAD3 SMAD family member 3 0.0541875
STK24 serine/threonine kinase 24 0.0539562
PICALM phosphatidylinositol binding clathrin assembly protein 0.0495124
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0478139
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0476964
MYH9 myosin, heavy chain 9, non-muscle 0.0475983
ANKRD11 ankyrin repeat domain 11 0.0457203
OGA O-GlcNAcase 0.0420628
DSCAM Down syndrome cell adhesion molecule 0.0415774
MARCHF6 membrane associated ring-CH-type finger 6 0.0413938
EREG epiregulin 0.0401912
ANXA11 annexin A11 0.0396397
ZFAND3 zinc finger, AN1-type domain 3 0.0390066
XPO1 exportin 1 0.0383099
PDIA4 protein disulfide isomerase family A, member 4 0.0379047
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0377335
CTNND1 catenin (cadherin-associated protein), delta 1 0.0371187
PCBP2 poly(rC) binding protein 2 0.0363235
NCKAP1 NCK-associated protein 1 0.0360789
ZMYM2 zinc finger, MYM-type 2 0.0360099
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0347606
AFDN afadin, adherens junction formation factor 0.0344259
FAT1 FAT atypical cadherin 1 0.0335441
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0324526
HYOU1 hypoxia up-regulated 1 0.0323181
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0322734
SPRED2 sprouty-related, EVH1 domain containing 2 0.0313923
PDS5B PDS5 cohesin associated factor B 0.0312304
SEPTIN9 septin 9 0.0311981
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0311518
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0308458
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0306658
LNX2 ligand of numb-protein X 2 0.0305945
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0300625
AHNAK AHNAK nucleoprotein 0.0300336
PLEC plectin 0.0299836
USP9X ubiquitin specific peptidase 9, X-linked 0.0292688
UBA2 ubiquitin-like modifier activating enzyme 2 0.0290607
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0288728
ADAM17 ADAM metallopeptidase domain 17 0.0287438
PUM2 pumilio RNA-binding family member 2 0.0286608
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.028493
RICTOR RPTOR independent companion of MTOR, complex 2 0.0283069
WAC WW domain containing adaptor with coiled-coil 0.0282537
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0281557
TM9SF3 transmembrane 9 superfamily member 3 0.0280171
COG5 component of oligomeric golgi complex 5 0.0278287
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0277736
GSK3B glycogen synthase kinase 3 beta 0.0276296
CTBP2 C-terminal binding protein 2 0.0275076
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0268564
ARHGAP32 Rho GTPase activating protein 32 0.0268543
ADARB1 adenosine deaminase, RNA-specific, B1 0.0267418
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0266012
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.026501
USP12 ubiquitin specific peptidase 12 0.0262877
IARS1 isoleucyl-tRNA synthetase 1 0.0262059
ATP13A3 ATPase type 13A3 0.026113
CNOT12 CCR4-NOT transcription complex subunit 12 0.0259464
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0258923
PPARG peroxisome proliferator-activated receptor gamma 0.0255507
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0254497
EFR3A EFR3 homolog A (S. cerevisiae) 0.0251608
MBNL2 muscleblind-like splicing regulator 2 0.0251262
PDZD8 PDZ domain containing 8 0.0250754
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0245418
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0237261
SLMAP sarcolemma associated protein 0.0236774
UBQLN1 ubiquilin 1 0.023596
RB1CC1 RB1-inducible coiled-coil 1 0.0235958
GARS1 glycyl-tRNA synthetase 1 0.0235262
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0234822
EPB41 erythrocyte membrane protein band 4.1 0.0232753
APP amyloid beta (A4) precursor protein 0.0232327
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0230162
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0226356
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0225649
RANBP9 RAN binding protein 9 0.0223166
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0221551
TPM3 tropomyosin 3 0.0220476
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0219476
ACTN4 actinin, alpha 4 0.0219322
MED13L mediator complex subunit 13-like 0.0218476
NF1 neurofibromin 1 0.0218221
SLC45A4 solute carrier family 45, member 4 0.021684
KDM3A lysine (K)-specific demethylase 3A 0.0216703
EIF4B eukaryotic translation initiation factor 4B 0.0216466
AFF1 AF4/FMR2 family, member 1 0.0215862
USP3 ubiquitin specific peptidase 3 0.0212556
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0212464
ARHGAP26 Rho GTPase activating protein 26 0.0212264
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0212245

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.148514
NDRG1 N-myc downstream regulated 1 -0.114586
TMSB10 thymosin beta 10 -0.111872
RPLP1 ribosomal protein, large, P1 -0.0927854
PTMA prothymosin, alpha -0.0898599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0846757
RPS6 ribosomal protein S6 -0.0844103
RPS19 ribosomal protein S19 -0.0834602
TPT1 tumor protein, translationally-controlled 1 -0.0636515
RPS3 ribosomal protein S3 -0.0615646
LOC102724023 ES1 protein homolog, mitochondrial -0.0614306
RPS8 ribosomal protein S8 -0.0557054
RPS12 ribosomal protein S12 -0.0549786
RPL23 ribosomal protein L23 -0.053359
FRY furry homolog (Drosophila) -0.0523223
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0483356
EGR1 early growth response 1 -0.0453811
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.044673
RPL37A ribosomal protein L37a -0.0436103
ACTG1 actin gamma 1 -0.043074
KRT20 keratin 20, type I -0.0427192
RPL35A ribosomal protein L35a -0.0427136
RPL26 ribosomal protein L26 -0.0410826
RPL37 ribosomal protein L37 -0.0390429
RPL9 ribosomal protein L9 -0.0389003
RPS17 ribosomal protein S17 -0.038822
RPL13A ribosomal protein L13a -0.0375586
RPL11 ribosomal protein L11 -0.0372162
RPL12 ribosomal protein L12 -0.0369113
RPL5 ribosomal protein L5 -0.0364635
RPLP2 ribosomal protein, large, P2 -0.0355475
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0353844
RPL18 ribosomal protein L18 -0.0342008
RPL19 ribosomal protein L19 -0.0330404
ITPKC inositol-trisphosphate 3-kinase C -0.0326915
RPL34 ribosomal protein L34 -0.032668
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0320831
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0311832
RPL31 ribosomal protein L31 -0.030271
RPS27A ribosomal protein S27a -0.0296531
JUN jun proto-oncogene -0.0295285
RPS14 ribosomal protein S14 -0.0291937
GCLC glutamate-cysteine ligase, catalytic subunit -0.0289276
EIF1 eukaryotic translation initiation factor 1 -0.0287056
ANXA2 annexin A2 -0.0286762
B2M beta-2-microglobulin -0.0278395
RPL28 ribosomal protein L28 -0.0274282
PGK1 phosphoglycerate kinase 1 -0.0270319
PKM pyruvate kinase, muscle -0.0267503
CNRIP1 cannabinoid receptor interacting protein 1 -0.0266186
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0264578
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0261087
RPS27 ribosomal protein S27 -0.0260865
RPS16 ribosomal protein S16 -0.0260499
S100P S100 calcium binding protein P -0.0256479
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0255837
PTPRK protein tyrosine phosphatase, receptor type, K -0.0255263
PDE4D phosphodiesterase 4D, cAMP-specific -0.0250093
CLDN4 claudin 4 -0.0250044
RPS21 ribosomal protein S21 -0.0248913
RPS29 ribosomal protein S29 -0.0247347
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0246558
TPI1 triosephosphate isomerase 1 -0.0243886
RPS13 ribosomal protein S13 -0.0243877
RPL21 ribosomal protein L21 -0.0242698
RPS24 ribosomal protein S24 -0.0235821
MACC1 metastasis associated in colon cancer 1 -0.0234111
RPL36A ribosomal protein L36a -0.0222456
KLF6 Kruppel-like factor 6 -0.0222335
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0222253
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0221548
ZBTB20 zinc finger and BTB domain containing 20 -0.0220575
BPTF bromodomain PHD finger transcription factor -0.0218765
RPLP0 ribosomal protein, large, P0 -0.0218424
RPL27 ribosomal protein L27 -0.021767
AGR2 anterior gradient 2 -0.021496
S100A6 S100 calcium binding protein A6 -0.021267
HM13 histocompatibility (minor) 13 -0.0211441
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0211421
RPL8 ribosomal protein L8 -0.0211166
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0210527
SERF2 small EDRK-rich factor 2 -0.0209197
S100A10 S100 calcium binding protein A10 -0.0206328
PATJ PATJ crumbs cell polarity complex component -0.0206175
HMGB1 high mobility group box 1 -0.0205729
RPS5 ribosomal protein S5 -0.0205588
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0204157
LOC112694756 uncharaterized LOC112694756 -0.0202939
RPL7 ribosomal protein L7 -0.0202589
GCC2 GRIP and coiled-coil domain containing 2 -0.0202121
ENO1 enolase 1, (alpha) -0.0201284
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.020048
TMC5 transmembrane channel-like 5 -0.0200118
RACK1 receptor for activated C kinase 1 -0.0199517
RPL36 ribosomal protein L36 -0.0197807
RPL7A ribosomal protein L7a -0.0197613
ZMYND8 zinc finger, MYND-type containing 8 -0.0195058
LDHA lactate dehydrogenase A -0.019444
RPL35 ribosomal protein L35 -0.0194435
RPL30 ribosomal protein L30 -0.0191451