| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.165555 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.140724 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.140277 |
| IGF2 | insulin-like growth factor 2 | 0.138576 |
| FNDC3B | fibronectin type III domain containing 3B | 0.133044 |
| TF | transferrin | 0.127467 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.11083 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.103382 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0809093 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0729862 |
| C3 | complement component 3 | 0.0695964 |
| ENO1 | enolase 1, (alpha) | 0.06508 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0643297 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0623376 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0572043 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0569704 |
| FN1 | fibronectin 1 | 0.0566209 |
| PCBP2 | poly(rC) binding protein 2 | 0.0541069 |
| RPL3 | ribosomal protein L3 | 0.0517911 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0516418 |
| ASPH | aspartate beta-hydroxylase | 0.0510715 |
| DTNA | dystrobrevin, alpha | 0.0497905 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0495176 |
| MYO1B | myosin IB | 0.0488741 |
| HELZ | helicase with zinc finger | 0.0449748 |
| PLIN2 | perilipin 2 | 0.044629 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0432274 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0426829 |
| CCNY | cyclin Y | 0.0425493 |
| RPS18 | ribosomal protein S18 | 0.04241 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0417833 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0416406 |
| AFDN | afadin, adherens junction formation factor | 0.0403045 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.04026 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0397781 |
| DSPP | dentin sialophosphoprotein | 0.0395633 |
| FAM107B | family with sequence similarity 107, member B | 0.0391934 |
| INSIG2 | insulin induced gene 2 | 0.0387769 |
| VEGFA | vascular endothelial growth factor A | 0.0387512 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0382645 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0376258 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0368648 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0362609 |
| FLNB | filamin B, beta | 0.0347055 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0342606 |
| CP | ceruloplasmin (ferroxidase) | 0.0337962 |
| HMGA1 | high mobility group AT-hook 1 | 0.0337096 |
| NUP58 | nucleoporin 58 | 0.0335093 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0334631 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0334209 |
| SVIL | supervillin | 0.0328721 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0326183 |
| RREB1 | ras responsive element binding protein 1 | 0.032283 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0320857 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0320175 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.031845 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0315725 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0312202 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0312119 |
| TNS1 | tensin 1 | 0.0310878 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0307502 |
| FMNL2 | formin-like 2 | 0.0302358 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0301191 |
| MSI2 | musashi RNA-binding protein 2 | 0.0296996 |
| GRB10 | growth factor receptor-bound protein 10 | 0.029616 |
| LRRC1 | leucine rich repeat containing 1 | 0.0283549 |
| WDR45B | WD repeat domain 45B | 0.0277151 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0276362 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0270216 |
| ATP13A3 | ATPase type 13A3 | 0.0268816 |
| PTK2 | protein tyrosine kinase 2 | 0.0268601 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0264646 |
| MTSS1 | metastasis suppressor 1 | 0.0264394 |
| KIF1B | kinesin family member 1B | 0.0259589 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0257207 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0256446 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0256207 |
| UBC | ubiquitin C | 0.0255947 |
| FBXO42 | F-box protein 42 | 0.0255189 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0253539 |
| NDRG1 | N-myc downstream regulated 1 | 0.0248205 |
| BRD4 | bromodomain containing 4 | 0.0247427 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0246103 |
| KIAA1217 | KIAA1217 | 0.0245332 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0243737 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0240326 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0237905 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0235588 |
| SNX9 | sorting nexin 9 | 0.0235084 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0234487 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0233247 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0231905 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0231602 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0228989 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0228667 |
| PDE8A | phosphodiesterase 8A | 0.0228253 |
| ANO6 | anoctamin 6 | 0.0224854 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0224595 |
| ANXA5 | annexin A5 | 0.0224538 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0224065 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0805377 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0750412 |
| RPL37A | ribosomal protein L37a | -0.0713739 |
| RPS6 | ribosomal protein S6 | -0.0693627 |
| MT2A | metallothionein 2A | -0.0684297 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0684036 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0598548 |
| APOB | apolipoprotein B | -0.0582094 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0571813 |
| RPLP1 | ribosomal protein, large, P1 | -0.0552406 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0549639 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0538155 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0531017 |
| RPS12 | ribosomal protein S12 | -0.0504967 |
| GPC3 | glypican 3 | -0.0495655 |
| TMSB10 | thymosin beta 10 | -0.0492397 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0475118 |
| EHBP1 | EH domain binding protein 1 | -0.0466646 |
| JMJD1C | jumonji domain containing 1C | -0.0451592 |
| RPL11 | ribosomal protein L11 | -0.0449156 |
| RPS8 | ribosomal protein S8 | -0.0447948 |
| RPL35A | ribosomal protein L35a | -0.0440063 |
| PTCHD4 | patched domain containing 4 | -0.043729 |
| RPS19 | ribosomal protein S19 | -0.0431217 |
| RPL23 | ribosomal protein L23 | -0.0429536 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0424804 |
| RPL26 | ribosomal protein L26 | -0.04234 |
| RRBP1 | ribosome binding protein 1 | -0.0418371 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0412353 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0407391 |
| RACK1 | receptor for activated C kinase 1 | -0.0402912 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0380449 |
| RPS27A | ribosomal protein S27a | -0.0373748 |
| RPL12 | ribosomal protein L12 | -0.036741 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0352747 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0347987 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0324955 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0324178 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0319421 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.030635 |
| FTL | ferritin, light polypeptide | -0.0305096 |
| RPLP0 | ribosomal protein, large, P0 | -0.029297 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0292926 |
| RPL9 | ribosomal protein L9 | -0.0289829 |
| RBM25 | RNA binding motif protein 25 | -0.0288357 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0288343 |
| IER3 | immediate early response 3 | -0.0281061 |
| APOE | apolipoprotein E | -0.0276109 |
| RPL36 | ribosomal protein L36 | -0.0270241 |
| ACTN4 | actinin, alpha 4 | -0.0270039 |
| RPL37 | ribosomal protein L37 | -0.0267637 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0264491 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0263187 |
| RPL5 | ribosomal protein L5 | -0.0259093 |
| ITGB5 | integrin, beta 5 | -0.0254684 |
| VMP1 | vacuole membrane protein 1 | -0.02514 |
| RPL30 | ribosomal protein L30 | -0.0248754 |
| RPL31 | ribosomal protein L31 | -0.0248012 |
| MALT1 | MALT1 paracaspase | -0.0243622 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0242501 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0239007 |
| RPS21 | ribosomal protein S21 | -0.0238026 |
| NPR2 | natriuretic peptide receptor 2 | -0.0235999 |
| CCDC146 | coiled-coil domain containing 146 | -0.0234782 |
| LCN2 | lipocalin 2 | -0.0233864 |
| PEG10 | paternally expressed 10 | -0.0230766 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0229825 |
| RPL13A | ribosomal protein L13a | -0.0228916 |
| RPL19 | ribosomal protein L19 | -0.0227632 |
| RPS24 | ribosomal protein S24 | -0.0226478 |
| EGR1 | early growth response 1 | -0.0224226 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0219293 |
| KIF5B | kinesin family member 5B | -0.0218507 |
| SELENOP | selenoprotein P | -0.0217841 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0215126 |
| OSMR | oncostatin M receptor | -0.021425 |
| RPL4 | ribosomal protein L4 | -0.0213218 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0211833 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0211521 |
| CENPF | centromere protein F, 350/400kDa | -0.021075 |
| RBM39 | RNA binding motif protein 39 | -0.0209712 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0208659 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0207325 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0204136 |
| SYNJ2 | synaptojanin 2 | -0.0203367 |
| RPS17 | ribosomal protein S17 | -0.0200958 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0200824 |
| RPL35 | ribosomal protein L35 | -0.0200741 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0200722 |
| PLAC8 | placenta-specific 8 | -0.0198043 |
| MKI67 | marker of proliferation Ki-67 | -0.0197681 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0195487 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0194248 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.0192199 |
| RPS5 | ribosomal protein S5 | -0.0189626 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0189026 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.018844 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0188437 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0187907 |
| RPL27 | ribosomal protein L27 | -0.0186768 |
