| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.159984 |
| FN1 | fibronectin 1 | 0.129336 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0961885 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0771182 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0721936 |
| NAV2 | neuron navigator 2 | 0.0704313 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.068682 |
| COL5A1 | collagen, type V, alpha 1 | 0.064413 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0643417 |
| ADM | adrenomedullin | 0.0539912 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0534442 |
| ZNF841 | zinc finger protein 841 | 0.0521029 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0520748 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0474541 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0472119 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0467101 |
| SMAD3 | SMAD family member 3 | 0.0455513 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0425404 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0424529 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0407146 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0405836 |
| AHNAK | AHNAK nucleoprotein | 0.0403772 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0403585 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0394891 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0382821 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0380418 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0372021 |
| RUNX2 | runt-related transcription factor 2 | 0.035142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0344543 |
| LOXL2 | lysyl oxidase-like 2 | 0.0335002 |
| FLNA | filamin A, alpha | 0.0332876 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0329379 |
| ATP13A3 | ATPase type 13A3 | 0.0305105 |
| RAI14 | retinoic acid induced 14 | 0.0289991 |
| HLA-C | major histocompatibility complex, class I, C | 0.028926 |
| PCBP2 | poly(rC) binding protein 2 | 0.0283652 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0280616 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0276449 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0272779 |
| ENO1 | enolase 1, (alpha) | 0.0269316 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0262461 |
| FLNB | filamin B, beta | 0.0260256 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0252054 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0247362 |
| DTNA | dystrobrevin, alpha | 0.0245552 |
| RPS18 | ribosomal protein S18 | 0.0245014 |
| PLEC | plectin | 0.0231265 |
| PRRC2A | proline-rich coiled-coil 2A | 0.022941 |
| MCL1 | myeloid cell leukemia 1 | 0.0228364 |
| CORO1C | coronin, actin binding protein, 1C | 0.0227361 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0226817 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0225983 |
| CEP250 | centrosomal protein 250kDa | 0.0223016 |
| APP | amyloid beta (A4) precursor protein | 0.0222222 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.02214 |
| ICAM1 | intercellular adhesion molecule 1 | 0.022057 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0219634 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0213973 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0212128 |
| EGFR | epidermal growth factor receptor | 0.0210929 |
| ASPH | aspartate beta-hydroxylase | 0.0201574 |
| RPL3 | ribosomal protein L3 | 0.0198842 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0195869 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0195223 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0192738 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.019227 |
| TNS3 | tensin 3 | 0.0189773 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0188098 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0183002 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0182755 |
| PGK1 | phosphoglycerate kinase 1 | 0.0182203 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0173911 |
| TGFB2 | transforming growth factor, beta 2 | 0.0172957 |
| PSG9 | pregnancy specific beta-1-glycoprotein 9 | 0.017225 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.017031 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0169217 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0168806 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0168471 |
| CAVIN1 | caveolae associated protein 1 | 0.0168042 |
| STC2 | stanniocalcin 2 | 0.0167854 |
| ACTN1 | actinin, alpha 1 | 0.016676 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0166204 |
| MYOF | myoferlin | 0.0164849 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.016345 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0162492 |
| SH3BP2 | SH3-domain binding protein 2 | 0.0162301 |
| GOLGA3 | golgin A3 | 0.0160673 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0160128 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 0.0159385 |
| MLPH | melanophilin | 0.0158828 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0157282 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.015624 |
| RPS12 | ribosomal protein S12 | 0.015526 |
| CADM1 | cell adhesion molecule 1 | 0.0155049 |
| GYS1 | glycogen synthase 1 (muscle) | 0.01537 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0151606 |
| COL3A1 | collagen, type III, alpha 1 | 0.0150937 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.01501 |
| RAD51B | RAD51 paralog B | 0.0148943 |
| NEK6 | NIMA-related kinase 6 | 0.0145847 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.244208 |
| HLA-B | major histocompatibility complex, class I, B | -0.120481 |
| FTL | ferritin, light polypeptide | -0.113749 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0852346 |
| TXNRD1 | thioredoxin reductase 1 | -0.0704206 |
| DEK | DEK proto-oncogene | -0.0687254 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0620153 |
| PFN1 | profilin 1 | -0.0466658 |
| CTSD | cathepsin D | -0.0459137 |
| MT1X | metallothionein 1X | -0.044058 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0435123 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0428024 |
| RPS6 | ribosomal protein S6 | -0.0407603 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0376235 |
| CCNL1 | cyclin L1 | -0.0338503 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0316456 |
| GOLGA4 | golgin A4 | -0.0313894 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0313455 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0304838 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0300846 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0300648 |
| DIAPH3 | diaphanous-related formin 3 | -0.0300552 |
| RPL35A | ribosomal protein L35a | -0.0290494 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0290475 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.027794 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0273746 |
| PKM | pyruvate kinase, muscle | -0.0267992 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0267842 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0260849 |
| CENPF | centromere protein F, 350/400kDa | -0.026039 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0258609 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0258011 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0257288 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0256339 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0254698 |
| LOC112694756 | uncharaterized LOC112694756 | -0.025466 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0253333 |
| MORF4L2 | mortality factor 4 like 2 | -0.025192 |
| RPL28 | ribosomal protein L28 | -0.0246835 |
| NF1 | neurofibromin 1 | -0.0245794 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0244658 |
| ANKRD17 | ankyrin repeat domain 17 | -0.024201 |
| TRAM1 | translocation associated membrane protein 1 | -0.0240725 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0238828 |
| ZNF207 | zinc finger protein 207 | -0.0231203 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0223703 |
| SRP54 | signal recognition particle 54kDa | -0.0223347 |
| S100A10 | S100 calcium binding protein A10 | -0.0223236 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0222058 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0221258 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0220685 |
| FUS | FUS RNA binding protein | -0.0219058 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0218829 |
| GRAMD2B | GRAM domain containing 2B | -0.0217354 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0216539 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0215697 |
| IL6ST | interleukin 6 signal transducer | -0.0214746 |
| HMGB1 | high mobility group box 1 | -0.021464 |
| FOSL1 | FOS-like antigen 1 | -0.0212446 |
| MAP1B | microtubule-associated protein 1B | -0.0211893 |
| VIM | vimentin | -0.0211697 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0211524 |
| NOP58 | NOP58 ribonucleoprotein | -0.0210757 |
| RHOA | ras homolog family member A | -0.0210077 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0207348 |
| RPLP2 | ribosomal protein, large, P2 | -0.0206206 |
| TUBA1B | tubulin, alpha 1b | -0.0205509 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0202946 |
| ACTG1 | actin gamma 1 | -0.0201157 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0200722 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0198807 |
| GOLGB1 | golgin B1 | -0.0197974 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0196077 |
| RPL8 | ribosomal protein L8 | -0.0195974 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0195817 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0195568 |
| ENAH | enabled homolog (Drosophila) | -0.0194333 |
| MTDH | metadherin | -0.0192292 |
| RPL7A | ribosomal protein L7a | -0.0189851 |
| TPI1 | triosephosphate isomerase 1 | -0.0189719 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0189673 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0188816 |
| RBM25 | RNA binding motif protein 25 | -0.0187135 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.018575 |
| BRD2 | bromodomain containing 2 | -0.0185645 |
| SRPK2 | SRSF protein kinase 2 | -0.0184585 |
| NEK7 | NIMA-related kinase 7 | -0.0183946 |
| OLA1 | Obg-like ATPase 1 | -0.0182267 |
| TAOK3 | TAO kinase 3 | -0.0181836 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0179827 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0178715 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0178313 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0177398 |
| USP15 | ubiquitin specific peptidase 15 | -0.0176888 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0176728 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0176053 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.017461 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0174472 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0172687 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0170913 |
