Dapagliflozin ((2S)-1,2-propanediol, hydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.117346
FAT1 FAT atypical cadherin 1 0.113418
RPL3 ribosomal protein L3 0.113399
GOLGA4 golgin A4 0.0744773
EEF2 eukaryotic translation elongation factor 2 0.0720767
RPS18 ribosomal protein S18 0.0631671
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0604781
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0489962
KMT2C lysine (K)-specific methyltransferase 2C 0.0467886
POTEF POTE ankyrin domain family, member F 0.0449368
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0434772
LMO7 LIM domain 7 0.039637
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0390073
PTBP3 polypyrimidine tract binding protein 3 0.0385238
SETD5 SET domain containing 5 0.0377684
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0375594
AKAP13 A kinase (PRKA) anchor protein 13 0.0327304
MED13L mediator complex subunit 13-like 0.0321947
UBA6 ubiquitin-like modifier activating enzyme 6 0.032092
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0318988
ANKRD11 ankyrin repeat domain 11 0.0317897
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0309154
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0306381
PDIA6 protein disulfide isomerase family A, member 6 0.0305288
WAC WW domain containing adaptor with coiled-coil 0.0296138
TJP1 tight junction protein 1 0.0294446
EREG epiregulin 0.0294088
COG5 component of oligomeric golgi complex 5 0.0291558
NKTR natural killer cell triggering receptor 0.0285138
CCNL1 cyclin L1 0.0284929
LRP6 low density lipoprotein receptor-related protein 6 0.0284135
SREBF2 sterol regulatory element binding transcription factor 2 0.0278426
COPA coatomer protein complex, subunit alpha 0.0276552
HYOU1 hypoxia up-regulated 1 0.0276507
CD46 CD46 molecule, complement regulatory protein 0.0273471
TFG TRK-fused gene 0.0273042
PSAT1 phosphoserine aminotransferase 1 0.0270301
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0264
ANXA11 annexin A11 0.0259745
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0257001
RAB6A RAB6A, member RAS oncogene family 0.0256293
PTEN phosphatase and tensin homolog 0.0253415
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0252111
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0250204
RNF145 ring finger protein 145 0.0248828
SND1 staphylococcal nuclease and tudor domain containing 1 0.0247342
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0247248
SNX9 sorting nexin 9 0.0246076
EXT1 exostosin glycosyltransferase 1 0.0245435
CTBP2 C-terminal binding protein 2 0.0243979
SRP54 signal recognition particle 54kDa 0.0240947
RBM33 RNA binding motif protein 33 0.0238313
SFPQ splicing factor proline/glutamine-rich 0.0235943
RPL21 ribosomal protein L21 0.0233036
MYH9 myosin, heavy chain 9, non-muscle 0.0232923
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0231462
KIF16B kinesin family member 16B 0.0230918
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0229108
TMF1 TATA element modulatory factor 1 0.0226682
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0223997
BIRC6 baculoviral IAP repeat containing 6 0.0223167
UBE2H ubiquitin-conjugating enzyme E2H 0.0218927
SRRM2 serine/arginine repetitive matrix 2 0.0218543
DSCAM Down syndrome cell adhesion molecule 0.0216388
ELP2 elongator acetyltransferase complex subunit 2 0.0215388
KDM6A lysine (K)-specific demethylase 6A 0.0214688
AKAP9 A kinase (PRKA) anchor protein 9 0.0214674
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0213243
MB21D2 Mab-21 domain containing 2 0.0212489
KMT2E lysine (K)-specific methyltransferase 2E 0.021177
NCOR2 nuclear receptor corepressor 2 0.020772
NCKAP1 NCK-associated protein 1 0.0206935
FNDC3B fibronectin type III domain containing 3B 0.0206468
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0203808
TSC22D2 TSC22 domain family, member 2 0.0198652
MKRN1 makorin ring finger protein 1 0.0198177
VEGFA vascular endothelial growth factor A 0.0198062
CNOT1 CCR4-NOT transcription complex, subunit 1 0.019775
PICALM phosphatidylinositol binding clathrin assembly protein 0.0197627
SCFD1 sec1 family domain containing 1 0.0196452
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0195636
UBE3A ubiquitin protein ligase E3A 0.019507
RCOR1 REST corepressor 1 0.0194536
ZFC3H1 zinc finger, C3H1-type containing 0.0193433
RANBP9 RAN binding protein 9 0.0192062
XPO1 exportin 1 0.0190666
MCL1 myeloid cell leukemia 1 0.0190201
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0190194
ZCCHC7 zinc finger, CCHC domain containing 7 0.0188278
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0187884
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0187266
NRDC nardilysin convertase 0.0185937
ETNK1 ethanolamine kinase 1 0.0185526
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0183764
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0183297
BRD2 bromodomain containing 2 0.01828
SEC31A SEC31 homolog A (S. cerevisiae) 0.0182038
ADAM17 ADAM metallopeptidase domain 17 0.0181227
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0180609
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0180278

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.217576
RPLP1 ribosomal protein, large, P1 -0.196448
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155006
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.140044
PTPRR protein tyrosine phosphatase, receptor type, R -0.118674
RPS6 ribosomal protein S6 -0.0935253
RPS8 ribosomal protein S8 -0.0922728
RPLP0 ribosomal protein, large, P0 -0.0919104
TMSB10 thymosin beta 10 -0.0889792
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0865609
ANXA2 annexin A2 -0.0798798
RPL35A ribosomal protein L35a -0.0788771
PDE4D phosphodiesterase 4D, cAMP-specific -0.0728091
ACTG1 actin gamma 1 -0.0726937
RPS19 ribosomal protein S19 -0.0710955
BACE2 beta-site APP-cleaving enzyme 2 -0.0702862
RPL34 ribosomal protein L34 -0.0669795
PTMA prothymosin, alpha -0.063579
KLF5 Kruppel-like factor 5 (intestinal) -0.0635524
RPS24 ribosomal protein S24 -0.0632472
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0628598
THSD4 thrombospondin, type I, domain containing 4 -0.0623859
RPS21 ribosomal protein S21 -0.0596747
RPL26 ribosomal protein L26 -0.0582652
RPLP2 ribosomal protein, large, P2 -0.0582145
RPS27A ribosomal protein S27a -0.0574781
MUC13 mucin 13, cell surface associated -0.0569438
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0557154
RPL13A ribosomal protein L13a -0.0539874
RNF213 ring finger protein 213 -0.0526773
RPL11 ribosomal protein L11 -0.0523559
RRBP1 ribosome binding protein 1 -0.0522779
RPL12 ribosomal protein L12 -0.0517809
RPL4 ribosomal protein L4 -0.0515541
PRSS3 protease, serine, 3 -0.0507406
RPL37A ribosomal protein L37a -0.0492734
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0465639
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0458761
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0447235
NDRG1 N-myc downstream regulated 1 -0.0443906
RPL23 ribosomal protein L23 -0.0421207
NAP1L1 nucleosome assembly protein 1-like 1 -0.0419472
RIGI RNA sensor RIG-I -0.0413718
RPL27A ribosomal protein L27a -0.0412295
PRELID2 PRELI domain containing 2 -0.0410411
PTPRK protein tyrosine phosphatase, receptor type, K -0.040956
RPS16 ribosomal protein S16 -0.0409397
RPL9 ribosomal protein L9 -0.0405323
ASPH aspartate beta-hydroxylase -0.04042
FOXP1 forkhead box P1 -0.0395375
RPS29 ribosomal protein S29 -0.0387129
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0386866
RPL30 ribosomal protein L30 -0.03811
IER3 immediate early response 3 -0.0380035
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0374568
RPS3 ribosomal protein S3 -0.0370669
TSPAN8 tetraspanin 8 -0.0367373
PATJ PATJ crumbs cell polarity complex component -0.0361042
TBCA tubulin folding cofactor A -0.0352028
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0350581
RPL28 ribosomal protein L28 -0.0349019
TC2N tandem C2 domains, nuclear -0.0348546
RPL37 ribosomal protein L37 -0.0345882
LOC112694756 uncharaterized LOC112694756 -0.0340823
SERINC5 serine incorporator 5 -0.0337138
RPL36 ribosomal protein L36 -0.0334613
RPL32 ribosomal protein L32 -0.0334345
MX1 MX dynamin-like GTPase 1 -0.0334071
LAMB3 laminin, beta 3 -0.0333615
VDAC1 voltage-dependent anion channel 1 -0.0332327
SMYD3 SET and MYND domain containing 3 -0.0327781
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0324691
FERMT1 fermitin family member 1 -0.032469
RPL8 ribosomal protein L8 -0.0324416
HLA-B major histocompatibility complex, class I, B -0.032408
RPS25 ribosomal protein S25 -0.0322835
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0320524
RAD51B RAD51 paralog B -0.0317021
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0317018
RPS5 ribosomal protein S5 -0.0316449
RPL38 ribosomal protein L38 -0.0315389
FUS FUS RNA binding protein -0.0313689
S100A10 S100 calcium binding protein A10 -0.0313536
RPS23 ribosomal protein S23 -0.0313461
RPL7A ribosomal protein L7a -0.030777
IRF1 interferon regulatory factor 1 -0.0307414
RPS17 ribosomal protein S17 -0.0304919
XAF1 XIAP associated factor 1 -0.0300083
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0300046
MSI2 musashi RNA-binding protein 2 -0.0298871
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0297117
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0296751
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0296444
AGR2 anterior gradient 2 -0.0294075
RPL36A ribosomal protein L36a -0.0293376
RPS20 ribosomal protein S20 -0.0291289
MAML2 mastermind-like 2 (Drosophila) -0.0288353
RPS14 ribosomal protein S14 -0.0287615
RPS15 ribosomal protein S15 -0.0287532
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0287379