| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.131331 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.125313 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.11293 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0784533 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0730061 |
| APP | amyloid beta (A4) precursor protein | 0.0712395 |
| FMNL2 | formin-like 2 | 0.0691049 |
| PCBP2 | poly(rC) binding protein 2 | 0.0690687 |
| RPS18 | ribosomal protein S18 | 0.0687219 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0640953 |
| CAPRIN2 | caprin family member 2 | 0.0609528 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0607358 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0602163 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0585276 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0577955 |
| POTEF | POTE ankyrin domain family, member F | 0.0569028 |
| PGK1 | phosphoglycerate kinase 1 | 0.055049 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0541943 |
| EREG | epiregulin | 0.0499964 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0460477 |
| RAI1 | retinoic acid induced 1 | 0.0449129 |
| AHNAK | AHNAK nucleoprotein | 0.0434251 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0420599 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0419254 |
| UBC | ubiquitin C | 0.0417532 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0405508 |
| EZR | ezrin | 0.0398673 |
| RPL3 | ribosomal protein L3 | 0.0396886 |
| TOP1 | topoisomerase (DNA) I | 0.03941 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0393078 |
| XPO1 | exportin 1 | 0.037414 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0361367 |
| ATP13A3 | ATPase type 13A3 | 0.0361282 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0359764 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0353738 |
| ENO1 | enolase 1, (alpha) | 0.0346011 |
| ADAR | adenosine deaminase, RNA-specific | 0.0339568 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0338211 |
| PRRC2A | proline-rich coiled-coil 2A | 0.033701 |
| LDHA | lactate dehydrogenase A | 0.0336939 |
| TPM3 | tropomyosin 3 | 0.0336342 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0335351 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0330729 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.032688 |
| TMEM41B | transmembrane protein 41B | 0.0325878 |
| TNPO1 | transportin 1 | 0.0325287 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0323132 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0320503 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0320083 |
| SFPQ | splicing factor proline/glutamine-rich | 0.031595 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0304894 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0303831 |
| FLNB | filamin B, beta | 0.0303532 |
| OGA | O-GlcNAcase | 0.0302491 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.0297884 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.0297093 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0295188 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0292221 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.029159 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0290648 |
| DENND5A | DENN/MADD domain containing 5A | 0.0286292 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0282109 |
| CENPF | centromere protein F, 350/400kDa | 0.0276267 |
| MATR3 | matrin 3 | 0.0275171 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0275087 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0274406 |
| TXNIP | thioredoxin interacting protein | 0.0270059 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0269866 |
| MT1X | metallothionein 1X | 0.0268043 |
| NCKAP1 | NCK-associated protein 1 | 0.0267791 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0266917 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.026488 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0261194 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.026118 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0260733 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0257889 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0250599 |
| NAV2 | neuron navigator 2 | 0.0250527 |
| RBM39 | RNA binding motif protein 39 | 0.0249294 |
| UBQLN1 | ubiquilin 1 | 0.0248397 |
| ECT2 | epithelial cell transforming 2 | 0.0248372 |
| AFAP1 | actin filament associated protein 1 | 0.0248269 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.024737 |
| KLF6 | Kruppel-like factor 6 | 0.0246521 |
| RTTN | rotatin | 0.024469 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0244417 |
| PYGB | phosphorylase, glycogen; brain | 0.0241751 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0239121 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0239 |
| SNX14 | sorting nexin 14 | 0.023459 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0231474 |
| IPO7 | importin 7 | 0.0231469 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0231431 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0229931 |
| PLEC | plectin | 0.0229914 |
| ITGB4 | integrin, beta 4 | 0.0229824 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0229143 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0228023 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0227753 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0227079 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211843 |
| TP63 | tumor protein p63 | -0.104032 |
| TMSB10 | thymosin beta 10 | -0.0863553 |
| HLA-B | major histocompatibility complex, class I, B | -0.0691208 |
| CADM2 | cell adhesion molecule 2 | -0.0649417 |
| CD44 | CD44 molecule (Indian blood group) | -0.0595082 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0593783 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0581681 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0538223 |
| FTL | ferritin, light polypeptide | -0.0532494 |
| VIM | vimentin | -0.0531979 |
| EHBP1 | EH domain binding protein 1 | -0.0516579 |
| EGR1 | early growth response 1 | -0.0477481 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0464092 |
| RPS19 | ribosomal protein S19 | -0.0426037 |
| RPS8 | ribosomal protein S8 | -0.0418811 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0403354 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0401834 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.038919 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0383839 |
| RPL37A | ribosomal protein L37a | -0.0377095 |
| SP100 | SP100 nuclear antigen | -0.0371698 |
| RPS6 | ribosomal protein S6 | -0.0368556 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0358789 |
| RPL35A | ribosomal protein L35a | -0.0342564 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0337925 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0336795 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0333356 |
| HDAC9 | histone deacetylase 9 | -0.0325981 |
| RIGI | RNA sensor RIG-I | -0.0313407 |
| EPHA4 | EPH receptor A4 | -0.0312375 |
| TNS3 | tensin 3 | -0.0305221 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0302042 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0297504 |
| RPL36 | ribosomal protein L36 | -0.0297381 |
| INTS6 | integrator complex subunit 6 | -0.0279085 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0269393 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0263084 |
| RPL28 | ribosomal protein L28 | -0.0248443 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0246534 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0246112 |
| PMP22 | peripheral myelin protein 22 | -0.0245192 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0240394 |
| RPLP2 | ribosomal protein, large, P2 | -0.0234182 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0232406 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0229391 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0225769 |
| RPL36A | ribosomal protein L36a | -0.0225499 |
| ACTG1 | actin gamma 1 | -0.0223542 |
| NEK10 | NIMA-related kinase 10 | -0.0223075 |
| S100A9 | S100 calcium binding protein A9 | -0.0222771 |
| PRELID2 | PRELI domain containing 2 | -0.0222336 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0217214 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0215552 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0215154 |
| RPS25 | ribosomal protein S25 | -0.0208886 |
| RPLP1 | ribosomal protein, large, P1 | -0.0205331 |
| JUN | jun proto-oncogene | -0.0202954 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.020022 |
| TP53 | tumor protein p53 | -0.019866 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0198379 |
| RPL34 | ribosomal protein L34 | -0.0193269 |
| RPL8 | ribosomal protein L8 | -0.0192581 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0190505 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0188319 |
| RPL12 | ribosomal protein L12 | -0.0185489 |
| PLSCR1 | phospholipid scramblase 1 | -0.0183273 |
| GOLGB1 | golgin B1 | -0.0183095 |
| RPL35 | ribosomal protein L35 | -0.0182847 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0181611 |
| RPL37 | ribosomal protein L37 | -0.0175496 |
| RPL26 | ribosomal protein L26 | -0.0175426 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0175356 |
| BPTF | bromodomain PHD finger transcription factor | -0.0173169 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.017306 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0171965 |
| RPL19 | ribosomal protein L19 | -0.0170816 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0169816 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0169643 |
| HM13 | histocompatibility (minor) 13 | -0.0169457 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0166865 |
| TBCA | tubulin folding cofactor A | -0.0166322 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0165536 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0163458 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0162912 |
| RPL7A | ribosomal protein L7a | -0.0162445 |
| TMSB4X | thymosin beta 4, X-linked | -0.0162312 |
| RASAL2 | RAS protein activator like 2 | -0.0162033 |
| TRIM56 | tripartite motif containing 56 | -0.0161408 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0160386 |
| RPL39 | ribosomal protein L39 | -0.0157277 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0156749 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.015611 |
| RPS21 | ribosomal protein S21 | -0.0156086 |
| RPS28 | ribosomal protein S28 | -0.0155707 |
| EGFR | epidermal growth factor receptor | -0.0155063 |
| RPS15 | ribosomal protein S15 | -0.0154492 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0154352 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0153242 |
| HOMER1 | homer scaffolding protein 1 | -0.0151816 |
