| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.158196 |
| CES1 | carboxylesterase 1 | 0.126386 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.112695 |
| LAMC2 | laminin, gamma 2 | 0.0988799 |
| SMAD3 | SMAD family member 3 | 0.090577 |
| PCBP2 | poly(rC) binding protein 2 | 0.0860549 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0843201 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0830396 |
| MCL1 | myeloid cell leukemia 1 | 0.0814905 |
| TOP1 | topoisomerase (DNA) I | 0.0662388 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0645226 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0639177 |
| HYOU1 | hypoxia up-regulated 1 | 0.0629362 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0627738 |
| RNF145 | ring finger protein 145 | 0.062025 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0590601 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0557857 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0529159 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.050951 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0495926 |
| PLEC | plectin | 0.0485109 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0481428 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0475765 |
| RNF149 | ring finger protein 149 | 0.0453427 |
| ATP13A3 | ATPase type 13A3 | 0.04519 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0446624 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0446616 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409173 |
| MED13L | mediator complex subunit 13-like | 0.0406329 |
| NCKAP1 | NCK-associated protein 1 | 0.0401446 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0393159 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0387145 |
| MSN | moesin | 0.037621 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.037483 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0361927 |
| UVRAG | UV radiation resistance associated | 0.035891 |
| RUNX1 | runt-related transcription factor 1 | 0.0358551 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0351448 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0343218 |
| OSMR | oncostatin M receptor | 0.0342818 |
| CCNL1 | cyclin L1 | 0.0340557 |
| TFG | TRK-fused gene | 0.0336259 |
| SLMAP | sarcolemma associated protein | 0.0328872 |
| PDE8A | phosphodiesterase 8A | 0.032161 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0320524 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0318795 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0311933 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0311891 |
| SP3 | Sp3 transcription factor | 0.031096 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0310167 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0305198 |
| TPM3 | tropomyosin 3 | 0.0302114 |
| CUL3 | cullin 3 | 0.0301375 |
| RPL3 | ribosomal protein L3 | 0.0297081 |
| TMEM45B | transmembrane protein 45B | 0.0297031 |
| NDRG1 | N-myc downstream regulated 1 | 0.0294799 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0292143 |
| MT2A | metallothionein 2A | 0.0287845 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0285178 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0285052 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0276329 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0274013 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0270715 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0270486 |
| SETD5 | SET domain containing 5 | 0.026926 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0269247 |
| RTN4 | reticulon 4 | 0.026874 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0262623 |
| YAP1 | Yes-associated protein 1 | 0.026178 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0261694 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0258768 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0258477 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0256597 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0254111 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0252649 |
| XPO1 | exportin 1 | 0.0251479 |
| FRY | furry homolog (Drosophila) | 0.0246141 |
| RASA2 | RAS p21 protein activator 2 | 0.0244853 |
| RAB27B | RAB27B, member RAS oncogene family | 0.02442 |
| FAM13A | family with sequence similarity 13, member A | 0.0242841 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0242605 |
| ADAR | adenosine deaminase, RNA-specific | 0.0237895 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0236864 |
| ATP11B | ATPase, class VI, type 11B | 0.0228934 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0228856 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0227791 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0227601 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0227513 |
| USP3 | ubiquitin specific peptidase 3 | 0.022744 |
| ZNF292 | zinc finger protein 292 | 0.0226112 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0223338 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0221064 |
| WDR26 | WD repeat domain 26 | 0.0218033 |
| PTK2 | protein tyrosine kinase 2 | 0.0217963 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0217666 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0216892 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0216004 |
| STK24 | serine/threonine kinase 24 | 0.0213422 |
| SNX9 | sorting nexin 9 | 0.0213013 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0212975 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.293496 |
| TMSB10 | thymosin beta 10 | -0.105528 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0972878 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0794686 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0642501 |
| ACTG1 | actin gamma 1 | -0.057599 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0555617 |
| INTS6 | integrator complex subunit 6 | -0.0545206 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0531013 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.051952 |
| RPLP1 | ribosomal protein, large, P1 | -0.0504413 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0466964 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0430878 |
| PTMA | prothymosin, alpha | -0.0429599 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0428961 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0420827 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0395861 |
| EGR1 | early growth response 1 | -0.0392743 |
| RPL35A | ribosomal protein L35a | -0.0390099 |
| MAP7 | microtubule-associated protein 7 | -0.0390041 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0389601 |
| NABP1 | nucleic acid binding protein 1 | -0.0387374 |
| S100A10 | S100 calcium binding protein A10 | -0.0380949 |
| EMP1 | epithelial membrane protein 1 | -0.0378574 |
| H1-0 | H1.0 linker histone | -0.0363549 |
| ANXA2 | annexin A2 | -0.0337483 |
| MORF4L2 | mortality factor 4 like 2 | -0.0331772 |
| HOMER1 | homer scaffolding protein 1 | -0.0326098 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0322504 |
| GOLGB1 | golgin B1 | -0.0322363 |
| RPS24 | ribosomal protein S24 | -0.0298043 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0292689 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0285367 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0283407 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0270717 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0270519 |
| PRKCA | protein kinase C, alpha | -0.0269451 |
| SEC61G | Sec61 gamma subunit | -0.0266638 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0266237 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0264355 |
| AHNAK | AHNAK nucleoprotein | -0.0260165 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0259624 |
| CANX | calnexin | -0.0259007 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0256631 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0252286 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0250808 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0250022 |
| RPL34 | ribosomal protein L34 | -0.0249134 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0246649 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0241122 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0238968 |
| AGR2 | anterior gradient 2 | -0.023769 |
| EGFR | epidermal growth factor receptor | -0.0235962 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0235673 |
| RPLP0 | ribosomal protein, large, P0 | -0.0234852 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0233713 |
| FTL | ferritin, light polypeptide | -0.0233261 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0232275 |
| RPS8 | ribosomal protein S8 | -0.0231862 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0230573 |
| ASPH | aspartate beta-hydroxylase | -0.0228263 |
| GM2A | GM2 ganglioside activator | -0.022745 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0225264 |
| ARF1 | ADP-ribosylation factor 1 | -0.0224597 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0223415 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0222628 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0221629 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.02169 |
| EFNA5 | ephrin-A5 | -0.0216472 |
| ABLIM1 | actin binding LIM protein 1 | -0.0215142 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0212867 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0211435 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0210388 |
| CCND1 | cyclin D1 | -0.0206662 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0204213 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0203393 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0203355 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0200671 |
| RPS3 | ribosomal protein S3 | -0.0197343 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0196852 |
| GRAMD1B | GRAM domain containing 1B | -0.0195974 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0195653 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0193926 |
| SCEL | sciellin | -0.0193211 |
| CCNI | cyclin I | -0.0187433 |
| NBEAL1 | neurobeachin-like 1 | -0.0186289 |
| PRELID2 | PRELI domain containing 2 | -0.0185864 |
| EHBP1 | EH domain binding protein 1 | -0.0185393 |
| MYO1E | myosin IE | -0.0184704 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0182827 |
| RPL8 | ribosomal protein L8 | -0.0182682 |
| HLA-B | major histocompatibility complex, class I, B | -0.0182441 |
| NGLY1 | N-glycanase 1 | -0.018213 |
| IER3 | immediate early response 3 | -0.0181914 |
| ATF6 | activating transcription factor 6 | -0.0180822 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0180675 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0179856 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0178294 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0177782 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0176173 |
