| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCBP2 | poly(rC) binding protein 2 | 0.242839 |
| SMAD3 | SMAD family member 3 | 0.164356 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.139041 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.111172 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.109614 |
| FNDC3B | fibronectin type III domain containing 3B | 0.104291 |
| RUNX2 | runt-related transcription factor 2 | 0.0941761 |
| ATP13A3 | ATPase type 13A3 | 0.0885998 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0874698 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0786202 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0758289 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0750366 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0741035 |
| FAM13A | family with sequence similarity 13, member A | 0.0733623 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0733471 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0722809 |
| RBM39 | RNA binding motif protein 39 | 0.0684454 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0660194 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0658472 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0637511 |
| HELZ | helicase with zinc finger | 0.0601768 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0599258 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0556976 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0537005 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0494175 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.049006 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0484163 |
| MEF2A | myocyte enhancer factor 2A | 0.0478756 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0478455 |
| EREG | epiregulin | 0.047714 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0466093 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0464036 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0462008 |
| USP3 | ubiquitin specific peptidase 3 | 0.0445186 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.044267 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.044213 |
| APP | amyloid beta (A4) precursor protein | 0.0436467 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0435375 |
| SIK3 | SIK family kinase 3 | 0.0432552 |
| MYO1B | myosin IB | 0.0424687 |
| SPAG9 | sperm associated antigen 9 | 0.0424324 |
| OGA | O-GlcNAcase | 0.0419879 |
| SETD5 | SET domain containing 5 | 0.0419769 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0416345 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0412206 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0410691 |
| PARD3 | par-3 family cell polarity regulator | 0.0409665 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0407093 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0401666 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0399082 |
| LOXL2 | lysyl oxidase-like 2 | 0.0397658 |
| NUP58 | nucleoporin 58 | 0.0395019 |
| FLNB | filamin B, beta | 0.0393395 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0386236 |
| FAM107B | family with sequence similarity 107, member B | 0.0385892 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0383168 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0381641 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0375341 |
| ANKRD11 | ankyrin repeat domain 11 | 0.037136 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0365126 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0360951 |
| CD44 | CD44 molecule (Indian blood group) | 0.0360668 |
| TGM2 | transglutaminase 2 | 0.0358447 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0355409 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0353923 |
| NEK7 | NIMA-related kinase 7 | 0.0353062 |
| RNF145 | ring finger protein 145 | 0.0350703 |
| CCNL1 | cyclin L1 | 0.035009 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0346968 |
| MB21D2 | Mab-21 domain containing 2 | 0.0345847 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0338597 |
| PTK2 | protein tyrosine kinase 2 | 0.0337605 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0337268 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0337007 |
| NDRG1 | N-myc downstream regulated 1 | 0.0336298 |
| MYO10 | myosin X | 0.0335319 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.033036 |
| ADD3 | adducin 3 (gamma) | 0.0330301 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0326135 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0324583 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0323197 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0321753 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0321723 |
| NBAS | neuroblastoma amplified sequence | 0.0321517 |
| PHIP | pleckstrin homology domain interacting protein | 0.0317328 |
| XPO1 | exportin 1 | 0.0313276 |
| ECE1 | endothelin converting enzyme 1 | 0.0311782 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.031086 |
| WDR45B | WD repeat domain 45B | 0.0307536 |
| TXNRD1 | thioredoxin reductase 1 | 0.0304824 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0304699 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0303471 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.030119 |
| RIOK3 | RIO kinase 3 | 0.0298051 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0297847 |
| MED13L | mediator complex subunit 13-like | 0.029726 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0295712 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0293706 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0292558 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0287788 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.116642 |
| VIM | vimentin | -0.110944 |
| FN1 | fibronectin 1 | -0.10469 |
| LOX | lysyl oxidase | -0.0891202 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.081877 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0786413 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0777325 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.077265 |
| HMGA2 | high mobility group AT-hook 2 | -0.0746154 |
| SYT1 | synaptotagmin I | -0.0617584 |
| GLCCI1 | glucocorticoid induced 1 | -0.057509 |
| DST | dystonin | -0.0547713 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0510765 |
| EHBP1 | EH domain binding protein 1 | -0.049839 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0478248 |
| ZNF804A | zinc finger protein 804A | -0.0461655 |
| CDH13 | cadherin 13 | -0.0459056 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0446888 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0413917 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0405879 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0385509 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0375385 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0366137 |
| BPTF | bromodomain PHD finger transcription factor | -0.0347837 |
| RPS19 | ribosomal protein S19 | -0.0342531 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0338847 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0337411 |
| MYO9A | myosin IXA | -0.0336736 |
| RPLP1 | ribosomal protein, large, P1 | -0.0331595 |
| NTN4 | netrin 4 | -0.033129 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0327179 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0322774 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0311813 |
| RASAL2 | RAS protein activator like 2 | -0.031002 |
| EXOC4 | exocyst complex component 4 | -0.0296164 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0295167 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0292552 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0291318 |
| SUMF1 | sulfatase modifying factor 1 | -0.0290683 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0288127 |
| RAD51B | RAD51 paralog B | -0.0286187 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0285414 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0283183 |
| TMSB4X | thymosin beta 4, X-linked | -0.028202 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0281364 |
| OXR1 | oxidation resistance 1 | -0.027688 |
| MECOM | MDS1 and EVI1 complex locus | -0.0275339 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0274586 |
| HM13 | histocompatibility (minor) 13 | -0.0271555 |
| FNIP1 | folliculin interacting protein 1 | -0.0261252 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0257489 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0255632 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0253534 |
| CANX | calnexin | -0.0251321 |
| GOLGB1 | golgin B1 | -0.0248438 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0245113 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.024461 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0244598 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0242287 |
| SEPTIN2 | septin 2 | -0.0241881 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0240778 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0240091 |
| AHNAK | AHNAK nucleoprotein | -0.0239964 |
| FBN1 | fibrillin 1 | -0.0239362 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0239232 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0239138 |
| PRKCA | protein kinase C, alpha | -0.0237967 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0237774 |
| PCNX4 | pecanex 4 | -0.0236637 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0234876 |
| ATM | ATM serine/threonine kinase | -0.0234184 |
| RPL35A | ribosomal protein L35a | -0.0232354 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0231426 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0230103 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0226373 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0225902 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0225799 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0223828 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0222481 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0220419 |
| PRSS23 | protease, serine, 23 | -0.0220236 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0220226 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0219587 |
| MAP1B | microtubule-associated protein 1B | -0.0218723 |
| HDLBP | high density lipoprotein binding protein | -0.0218483 |
| ENOSF1 | enolase superfamily member 1 | -0.0216234 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0215858 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0215507 |
| CUX1 | cut-like homeobox 1 | -0.0214975 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0214306 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.02132 |
| RSU1 | Ras suppressor protein 1 | -0.0210369 |
| NRP1 | neuropilin 1 | -0.0209968 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0208651 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0208347 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.020597 |
| VCL | vinculin | -0.0205418 |
| R3HDM2 | R3H domain containing 2 | -0.0202858 |
| RPL34 | ribosomal protein L34 | -0.0200924 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0200344 |
