| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.174247 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0843799 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0763 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0694704 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0654722 |
| FGB | fibrinogen beta chain | 0.0648731 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0577775 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0569011 |
| APP | amyloid beta (A4) precursor protein | 0.0552832 |
| TPM3 | tropomyosin 3 | 0.0552809 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0524253 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0471162 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0464647 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0440846 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0437247 |
| PCBP2 | poly(rC) binding protein 2 | 0.0429326 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.041829 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.039994 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0387924 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0385905 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0373211 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0367044 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0353777 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0348289 |
| GRAMD1B | GRAM domain containing 1B | 0.0344593 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0342366 |
| NTN4 | netrin 4 | 0.0336972 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0327859 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0325294 |
| RTN4 | reticulon 4 | 0.0323169 |
| MYOF | myoferlin | 0.0315786 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0315193 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0294013 |
| FAM107B | family with sequence similarity 107, member B | 0.029333 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0290822 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0289597 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0287057 |
| ASPH | aspartate beta-hydroxylase | 0.0286989 |
| CALU | calumenin | 0.0278818 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0273926 |
| HYOU1 | hypoxia up-regulated 1 | 0.026886 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0266776 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.026639 |
| TMEM123 | transmembrane protein 123 | 0.0265256 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0263852 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0257503 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0254653 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0249066 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0247628 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0247057 |
| TNPO1 | transportin 1 | 0.0243303 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0242854 |
| FGG | fibrinogen gamma chain | 0.0242351 |
| PFKP | phosphofructokinase, platelet | 0.0238999 |
| KIF5B | kinesin family member 5B | 0.0235582 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0228401 |
| YME1L1 | YME1-like 1 ATPase | 0.0226929 |
| RPS18 | ribosomal protein S18 | 0.0226176 |
| WWOX | WW domain containing oxidoreductase | 0.0224917 |
| TPD52 | tumor protein D52 | 0.0223841 |
| ADAR | adenosine deaminase, RNA-specific | 0.0223741 |
| ANXA5 | annexin A5 | 0.0222372 |
| RPL3 | ribosomal protein L3 | 0.022202 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0221102 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0218609 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0211703 |
| CLTC | clathrin, heavy chain (Hc) | 0.0210592 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0204768 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0202623 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0202137 |
| SMAD3 | SMAD family member 3 | 0.0199092 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0198157 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0196191 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.019392 |
| MKI67 | marker of proliferation Ki-67 | 0.0190179 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0189269 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0189167 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0188829 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.018689 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0186281 |
| ECT2 | epithelial cell transforming 2 | 0.0184377 |
| AHNAK | AHNAK nucleoprotein | 0.018405 |
| CALR | calreticulin | 0.0182929 |
| ANLN | anillin, actin binding protein | 0.0181752 |
| UBC | ubiquitin C | 0.0180941 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0178445 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.017549 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.017515 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0175052 |
| TPX2 | TPX2, microtubule-associated | 0.017171 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0171675 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0170721 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0169772 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0169506 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0169478 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0166805 |
| XPO1 | exportin 1 | 0.0166633 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0162255 |
| CPNE8 | copine VIII | 0.0161017 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0159309 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.158374 |
| TMSB10 | thymosin beta 10 | -0.14029 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0979338 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0809602 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0764003 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0730444 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0604532 |
| ACTG1 | actin gamma 1 | -0.0561232 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0545514 |
| FTL | ferritin, light polypeptide | -0.0542541 |
| CMIP | c-Maf inducing protein | -0.0539919 |
| RPL36 | ribosomal protein L36 | -0.0512197 |
| RPS19 | ribosomal protein S19 | -0.0481555 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0467329 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0449205 |
| RPS12 | ribosomal protein S12 | -0.0448536 |
| FMNL2 | formin-like 2 | -0.0446352 |
| PARD3 | par-3 family cell polarity regulator | -0.0436245 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0414072 |
| RPLP1 | ribosomal protein, large, P1 | -0.0401325 |
| RPL37A | ribosomal protein L37a | -0.03967 |
| VIM | vimentin | -0.0394621 |
| DOCK5 | dedicator of cytokinesis 5 | -0.037961 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0367562 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0360562 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0349914 |
| DST | dystonin | -0.0344111 |
| RBM25 | RNA binding motif protein 25 | -0.0343958 |
| FLNB | filamin B, beta | -0.0340859 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0339193 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0337759 |
| IGF2 | insulin-like growth factor 2 | -0.0335851 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0330409 |
| RPS8 | ribosomal protein S8 | -0.0324829 |
| USP34 | ubiquitin specific peptidase 34 | -0.0317828 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0309259 |
| NEBL | nebulette | -0.0305037 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0296619 |
| RPS17 | ribosomal protein S17 | -0.0291071 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0290475 |
| PYGL | phosphorylase, glycogen, liver | -0.0287224 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0281067 |
| RPL35A | ribosomal protein L35a | -0.0267442 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.026412 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0255212 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0249291 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0247888 |
| PTMA | prothymosin, alpha | -0.0247258 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0246704 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.024278 |
| PFN1 | profilin 1 | -0.0241783 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0241347 |
| RPS27 | ribosomal protein S27 | -0.0236623 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0231574 |
| EGFR | epidermal growth factor receptor | -0.0231235 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0226989 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0226359 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0222944 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0222407 |
| RPL5 | ribosomal protein L5 | -0.0217828 |
| RPL37 | ribosomal protein L37 | -0.0214388 |
| DENND4A | DENN/MADD domain containing 4A | -0.0212762 |
| TPM1 | tropomyosin 1 (alpha) | -0.0210423 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0207294 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0206707 |
| RPL23 | ribosomal protein L23 | -0.0202554 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0201074 |
| MED13 | mediator complex subunit 13 | -0.0200777 |
| RPL9 | ribosomal protein L9 | -0.020021 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0196578 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0194583 |
| RPL31 | ribosomal protein L31 | -0.0193013 |
| RPS6 | ribosomal protein S6 | -0.0192995 |
| KYNU | kynureninase | -0.0191528 |
| RPL26 | ribosomal protein L26 | -0.019152 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0189845 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0189726 |
| SNX14 | sorting nexin 14 | -0.0189399 |
| NDRG1 | N-myc downstream regulated 1 | -0.018877 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0185551 |
| EXOC6B | exocyst complex component 6B | -0.0184223 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0183937 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0183655 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0183331 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0181748 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0181087 |
| NLK | nemo-like kinase | -0.0180603 |
| INTS6 | integrator complex subunit 6 | -0.0180597 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0180317 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0180038 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0179087 |
| ZNF207 | zinc finger protein 207 | -0.0179028 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0178202 |
| NOP58 | NOP58 ribonucleoprotein | -0.0178193 |
| WDR43 | WD repeat domain 43 | -0.0177297 |
| SBF2 | SET binding factor 2 | -0.0176749 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0176016 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0174637 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0172026 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0171772 |
