| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.152302 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.108846 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0937873 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0929323 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0903662 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0873073 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0787168 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0730419 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0696245 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0672698 |
| PCBP2 | poly(rC) binding protein 2 | 0.0648195 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0642171 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0612396 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0600675 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0599413 |
| PDE10A | phosphodiesterase 10A | 0.057114 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0547703 |
| TFG | TRK-fused gene | 0.0530601 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0522352 |
| CCNY | cyclin Y | 0.0515249 |
| PGK1 | phosphoglycerate kinase 1 | 0.0511812 |
| NDRG1 | N-myc downstream regulated 1 | 0.0494931 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0494767 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.049195 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0474678 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0473698 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0465408 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0457838 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0456997 |
| MEF2A | myocyte enhancer factor 2A | 0.0455361 |
| RYBP | RING1 and YY1 binding protein | 0.045519 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0449593 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0446092 |
| PTK2 | protein tyrosine kinase 2 | 0.0441461 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0435018 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0432731 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0431463 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0424783 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0418885 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.041355 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.040908 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0408304 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0401228 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0397413 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0395204 |
| SRPK2 | SRSF protein kinase 2 | 0.0393886 |
| MEIS2 | Meis homeobox 2 | 0.0389742 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0389392 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0388807 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0386796 |
| PTMA | prothymosin, alpha | 0.0386245 |
| CCNL1 | cyclin L1 | 0.0377631 |
| SDC2 | syndecan 2 | 0.0373917 |
| TMSB10 | thymosin beta 10 | 0.0371567 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0371132 |
| FAT1 | FAT atypical cadherin 1 | 0.0367265 |
| STK24 | serine/threonine kinase 24 | 0.0366977 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0365236 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0364176 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0360363 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.035985 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0355228 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0353271 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0350508 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.0346881 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0346138 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0343804 |
| RPS12 | ribosomal protein S12 | 0.0342007 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0341475 |
| FAM168B | family with sequence similarity 168, member B | 0.0334724 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0331354 |
| RCOR1 | REST corepressor 1 | 0.0324302 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.0317414 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0316849 |
| RLF | rearranged L-myc fusion | 0.0316512 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0315748 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0313898 |
| MANBA | mannosidase, beta A, lysosomal | 0.0312818 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.031138 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0310813 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0310281 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0309848 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0309785 |
| RSF1 | remodeling and spacing factor 1 | 0.0307658 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0306793 |
| HELZ | helicase with zinc finger | 0.0306216 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0305315 |
| B2M | beta-2-microglobulin | 0.0303792 |
| RPL23 | ribosomal protein L23 | 0.0303338 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0296518 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0295617 |
| RPS17 | ribosomal protein S17 | 0.0293629 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0293384 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0290381 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.029035 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0287817 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.0286091 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0285589 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.028514 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0282951 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.127535 |
| LAMB3 | laminin, beta 3 | -0.117097 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.109751 |
| ANXA2 | annexin A2 | -0.096266 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0916204 |
| KYNU | kynureninase | -0.090499 |
| LAMC2 | laminin, gamma 2 | -0.0886488 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0885202 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0789198 |
| SPAG9 | sperm associated antigen 9 | -0.0775461 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.074016 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.071673 |
| LMO7 | LIM domain 7 | -0.0696 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0691482 |
| ATOSA | atos homolog A | -0.0642626 |
| TJP1 | tight junction protein 1 | -0.0639709 |
| STC1 | stanniocalcin 1 | -0.0635524 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0631714 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0609145 |
| MYO1E | myosin IE | -0.0606601 |
| EZR | ezrin | -0.0605495 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0596032 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0591463 |
| LSAMP | limbic system-associated membrane protein | -0.0582546 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0574696 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0572518 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0563466 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.053862 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.053741 |
| RIGI | RNA sensor RIG-I | -0.053314 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0520252 |
| PARD3 | par-3 family cell polarity regulator | -0.0518527 |
| AK1 | adenylate kinase 1 | -0.0491939 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0491422 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0485188 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0468962 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0468026 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0465333 |
| VMP1 | vacuole membrane protein 1 | -0.0458942 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0457864 |
| SMYD3 | SET and MYND domain containing 3 | -0.045087 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0449936 |
| RAB10 | RAB10, member RAS oncogene family | -0.0448175 |
| EGR1 | early growth response 1 | -0.0442424 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0442371 |
| INTS6 | integrator complex subunit 6 | -0.0436851 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0434439 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0429442 |
| SVIL | supervillin | -0.0425552 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0420525 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0415934 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0411536 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0410526 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0408468 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0402849 |
| JMJD1C | jumonji domain containing 1C | -0.0399294 |
| CMIP | c-Maf inducing protein | -0.0381533 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0379899 |
| PRKCA | protein kinase C, alpha | -0.0371696 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0366008 |
| FOXO3 | forkhead box O3 | -0.0365448 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0364025 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0342544 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.033954 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0332107 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0330052 |
| RAB5A | RAB5A, member RAS oncogene family | -0.032616 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0323154 |
| FBXO11 | F-box protein 11 | -0.032249 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0320398 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0318418 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0314724 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0310274 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0308074 |
| KLHL24 | kelch-like family member 24 | -0.030415 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0304061 |
| MSN | moesin | -0.0303969 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0303808 |
| PRKCE | protein kinase C, epsilon | -0.0300966 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0298873 |
| VCL | vinculin | -0.0293624 |
| EPN2 | epsin 2 | -0.0292116 |
| PLEC | plectin | -0.029184 |
| ANKRD12 | ankyrin repeat domain 12 | -0.028951 |
| CNKSR3 | CNKSR family member 3 | -0.0284658 |
| AHNAK | AHNAK nucleoprotein | -0.0282582 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0282379 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0281992 |
| CALU | calumenin | -0.027952 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0276901 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0273173 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0273152 |
| RIOK3 | RIO kinase 3 | -0.0271371 |
| SDC4 | syndecan 4 | -0.0270625 |
| RAI14 | retinoic acid induced 14 | -0.0268254 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0267299 |
| S100A10 | S100 calcium binding protein A10 | -0.0267045 |
| ERBIN | erbb2 interacting protein | -0.0265801 |
| YBX3 | Y box binding protein 3 | -0.0265481 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0263403 |
