Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.154862
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.127587
EEF2 eukaryotic translation elongation factor 2 0.084488
CSDE1 cold shock domain containing E1, RNA-binding 0.0810649
RPS3 ribosomal protein S3 0.057059
PGK1 phosphoglycerate kinase 1 0.056668
RPL3 ribosomal protein L3 0.0544184
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0533394
RPS18 ribosomal protein S18 0.0533313
VIM vimentin 0.0480318
TMSB10 thymosin beta 10 0.0476649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0426549
SMAD3 SMAD family member 3 0.0422623
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0419593
HMGA1 high mobility group AT-hook 1 0.0408772
RPS12 ribosomal protein S12 0.0403368
YBX1 Y box binding protein 1 0.0402989
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0402582
PTMA prothymosin, alpha 0.0391827
TPM3 tropomyosin 3 0.0369972
RPS27 ribosomal protein S27 0.0354959
RPL37A ribosomal protein L37a 0.0350111
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0345111
HDGF hepatoma-derived growth factor 0.0339773
COPA coatomer protein complex, subunit alpha 0.0322325
BBX bobby sox homolog (Drosophila) 0.0309239
UBE2H ubiquitin-conjugating enzyme E2H 0.0307664
FTL ferritin, light polypeptide 0.0307013
CCNL1 cyclin L1 0.0306667
CAMTA1 calmodulin binding transcription activator 1 0.0305457
RBM25 RNA binding motif protein 25 0.0297066
ENO1 enolase 1, (alpha) 0.0295125
LDHA lactate dehydrogenase A 0.0293984
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0292549
UBC ubiquitin C 0.0286781
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0278935
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0276796
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0276704
TMEM165 transmembrane protein 165 0.0271227
RPS4X ribosomal protein S4, X-linked 0.027113
BAG6 BCL2-associated athanogene 6 0.0262239
EIF1 eukaryotic translation initiation factor 1 0.0260756
RPL13A ribosomal protein L13a 0.0260643
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0260129
RPL12 ribosomal protein L12 0.0258064
XPO6 exportin 6 0.0257017
EIF4B eukaryotic translation initiation factor 4B 0.0250614
KRT18 keratin 18, type I 0.0249562
PRPF8 pre-mRNA processing factor 8 0.0245955
ADAR adenosine deaminase, RNA-specific 0.0239574
TPM2 tropomyosin 2 (beta) 0.0236798
PKM pyruvate kinase, muscle 0.023447
PLEC plectin 0.0233588
RPL23 ribosomal protein L23 0.0233482
PDIA4 protein disulfide isomerase family A, member 4 0.0231447
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0230542
RPS14 ribosomal protein S14 0.0229105
MEF2D myocyte enhancer factor 2D 0.0221794
MARCHF6 membrane associated ring-CH-type finger 6 0.0220871
RPL31 ribosomal protein L31 0.0218513
MATR3 matrin 3 0.0217184
URI1 URI1, prefoldin-like chaperone 0.0216414
KDM3A lysine (K)-specific demethylase 3A 0.0212847
SQSTM1 sequestosome 1 0.0211089
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0209719
RPS7 ribosomal protein S7 0.0209588
WRN Werner syndrome, RecQ helicase-like 0.0207055
RPS17 ribosomal protein S17 0.020596
DDIT4 DNA-damage-inducible transcript 4 0.020459
SREBF2 sterol regulatory element binding transcription factor 2 0.0204371
TAGLN2 transgelin 2 0.020236
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0201967
RPL37 ribosomal protein L37 0.0200538
SETD5 SET domain containing 5 0.0198824
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0195644
PTEN phosphatase and tensin homolog 0.0194219
EEF1G eukaryotic translation elongation factor 1 gamma 0.0192284
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0191766
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0188368
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0187695
FNBP4 formin binding protein 4 0.01863
NEK7 NIMA-related kinase 7 0.0186242
PREPL prolyl endopeptidase-like 0.0186102
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.018577
GNAS GNAS complex locus 0.0185539
GARS1 glycyl-tRNA synthetase 1 0.0185526
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0185471
RSRC2 arginine/serine-rich coiled-coil 2 0.0184384
WDR43 WD repeat domain 43 0.0183436
CEP250 centrosomal protein 250kDa 0.0180707
TNPO3 transportin 3 0.0180659
POTEF POTE ankyrin domain family, member F 0.0177787
ZYX zyxin 0.0176454
VAT1 vesicle amine transport 1 0.0173931
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0173893
GPX4 glutathione peroxidase 4 0.0172672
LDHB lactate dehydrogenase B 0.0170981
GOLGA4 golgin A4 0.0170267
PER1 period circadian clock 1 0.0170262
UBAP2L ubiquitin associated protein 2-like 0.0169187

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.180122
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149674
TFPI2 tissue factor pathway inhibitor 2 -0.13973
GRAMD1B GRAM domain containing 1B -0.116559
YBX3 Y box binding protein 3 -0.112383
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0999897
PDE4D phosphodiesterase 4D, cAMP-specific -0.0863682
RIMS2 regulating synaptic membrane exocytosis 2 -0.0728465
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0689671
TM4SF1 transmembrane 4 L six family member 1 -0.0661919
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0629403
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0580843
DOCK5 dedicator of cytokinesis 5 -0.0566422
KTN1 kinectin 1 (kinesin receptor) -0.0556332
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0554886
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0539083
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0538068
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0530321
OSMR oncostatin M receptor -0.0522277
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0513311
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.051115
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0507784
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0495899
SLC38A2 solute carrier family 38, member 2 -0.0492866
PDE10A phosphodiesterase 10A -0.0471128
PRH1 proline-rich protein HaeIII subfamily 1 -0.0470086
RICTOR RPTOR independent companion of MTOR, complex 2 -0.046687
TAS2R14 taste receptor, type 2, member 14 -0.0442752
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0439222
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0431478
NABP1 nucleic acid binding protein 1 -0.0428146
ELL2 elongation factor, RNA polymerase II, 2 -0.0427885
AFF3 AF4/FMR2 family, member 3 -0.0424776
RAB10 RAB10, member RAS oncogene family -0.0417145
BPTF bromodomain PHD finger transcription factor -0.0411796
ANO6 anoctamin 6 -0.0410367
THSD4 thrombospondin, type I, domain containing 4 -0.0405139
NIPBL Nipped-B homolog (Drosophila) -0.0401963
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0397985
DNAH14 dynein, axonemal, heavy chain 14 -0.0386843
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0383485
PDLIM5 PDZ and LIM domain 5 -0.0382752
NF1 neurofibromin 1 -0.038098
ACTG1 actin gamma 1 -0.0378022
NBEAL1 neurobeachin-like 1 -0.0361326
TPT1 tumor protein, translationally-controlled 1 -0.0353692
IGF1R insulin-like growth factor 1 receptor -0.035226
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0343731
STC1 stanniocalcin 1 -0.0336058
INTS6 integrator complex subunit 6 -0.0335993
SPIDR scaffolding protein involved in DNA repair -0.0335451
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0331826
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0330071
GPHN gephyrin -0.0327142
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0326188
BRD2 bromodomain containing 2 -0.0325496
FUS FUS RNA binding protein -0.0325297
ZFAND3 zinc finger, AN1-type domain 3 -0.0324893
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0323015
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0322924
WNT2B wingless-type MMTV integration site family, member 2B -0.0318297
PATJ PATJ crumbs cell polarity complex component -0.0310245
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0308554
FBXO11 F-box protein 11 -0.0300277
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0299426
WDR70 WD repeat domain 70 -0.0296238
PRKCE protein kinase C, epsilon -0.0293699
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.02934
AEBP2 AE binding protein 2 -0.0293164
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0292783
DST dystonin -0.0291826
EHBP1 EH domain binding protein 1 -0.0291748
MKI67 marker of proliferation Ki-67 -0.0289855
RPS15 ribosomal protein S15 -0.0289681
DENND5B DENN/MADD domain containing 5B -0.028966
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0286875
EXOC4 exocyst complex component 4 -0.0285966
TAOK1 TAO kinase 1 -0.0283845
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0279513
ZNF207 zinc finger protein 207 -0.027676
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0275882
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0274094
MBD5 methyl-CpG binding domain protein 5 -0.0270852
RABGAP1L RAB GTPase activating protein 1-like -0.0270152
R3HDM2 R3H domain containing 2 -0.026888
GOLGB1 golgin B1 -0.0268661
YAP1 Yes-associated protein 1 -0.0266853
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0265975
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0263763
HMGA2 high mobility group AT-hook 2 -0.026253
KDM2A lysine (K)-specific demethylase 2A -0.0260448
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0259783
HLA-B major histocompatibility complex, class I, B -0.0259475
IL6ST interleukin 6 signal transducer -0.025795
CDK17 cyclin-dependent kinase 17 -0.0252995
STK4 serine/threonine kinase 4 -0.0252583
MCL1 myeloid cell leukemia 1 -0.0250572
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0249213
BZW1 basic leucine zipper and W2 domains 1 -0.0248772
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.024616