Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.105894
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0807362
FNDC3B fibronectin type III domain containing 3B 0.0786969
MYH9 myosin, heavy chain 9, non-muscle 0.076102
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0651386
NDRG1 N-myc downstream regulated 1 0.0640046
PCBP2 poly(rC) binding protein 2 0.0602622
GRB10 growth factor receptor-bound protein 10 0.0577224
PLEC plectin 0.0555845
MSN moesin 0.0503097
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431671
TPM3 tropomyosin 3 0.042729
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0425131
RPL3 ribosomal protein L3 0.0399487
HSPA8 heat shock 70kDa protein 8 0.038575
EEF2 eukaryotic translation elongation factor 2 0.038283
NAMPT nicotinamide phosphoribosyltransferase 0.0379226
RPS18 ribosomal protein S18 0.0356627
FXR1 fragile X mental retardation, autosomal homolog 1 0.0344046
DSPP dentin sialophosphoprotein 0.0320064
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0293149
CALR calreticulin 0.0285875
FHIT fragile histidine triad 0.027982
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0279584
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0276826
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0276107
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270171
UBA6 ubiquitin-like modifier activating enzyme 6 0.0262856
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0260648
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0249369
APP amyloid beta (A4) precursor protein 0.0249206
PTK2 protein tyrosine kinase 2 0.0237271
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0234722
RYBP RING1 and YY1 binding protein 0.022867
ADAR adenosine deaminase, RNA-specific 0.0228551
SSBP2 single-stranded DNA binding protein 2 0.0228378
IRF6 interferon regulatory factor 6 0.0227992
FAM13A family with sequence similarity 13, member A 0.0222781
G0S2 G0/G1 switch 2 0.0219114
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0215264
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0212862
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0211319
CCNL1 cyclin L1 0.0209296
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0208816
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0203446
ICAM1 intercellular adhesion molecule 1 0.0201327
CORO1C coronin, actin binding protein, 1C 0.0200501
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0200395
TRIO trio Rho guanine nucleotide exchange factor 0.0195953
ATP13A3 ATPase type 13A3 0.0195589
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0195585
CCNY cyclin Y 0.0192349
TNIP1 TNFAIP3 interacting protein 1 0.0192314
ANXA5 annexin A5 0.0191029
LAMC2 laminin, gamma 2 0.0188842
SOD2 superoxide dismutase 2, mitochondrial 0.0184724
PPARD peroxisome proliferator-activated receptor delta 0.0184034
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0182821
NRIP1 nuclear receptor interacting protein 1 0.0182497
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0180216
TSPAN15 tetraspanin 15 0.0180155
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0179514
SMAD3 SMAD family member 3 0.0178228
PDIA6 protein disulfide isomerase family A, member 6 0.0177829
TRA2B transformer 2 beta homolog (Drosophila) 0.0177616
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 0.017744
ERRFI1 ERBB receptor feedback inhibitor 1 0.0176801
NUP58 nucleoporin 58 0.0174832
FERMT2 fermitin family member 2 0.0174438
HPCAL1 hippocalcin-like 1 0.0172531
ZMIZ1 zinc finger, MIZ-type containing 1 0.0170321
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0167956
ZFP36L1 ZFP36 ring finger protein-like 1 0.0162712
CPNE8 copine VIII 0.0161656
HMGA1 high mobility group AT-hook 1 0.0159469
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.015929
RNF145 ring finger protein 145 0.0158238
PDIA4 protein disulfide isomerase family A, member 4 0.0157502
VEGFA vascular endothelial growth factor A 0.0157002
AHDC1 AT hook, DNA binding motif, containing 1 0.0156564
EPS8 epidermal growth factor receptor pathway substrate 8 0.0152877
RAD23B RAD23 homolog B (S. cerevisiae) 0.0150512
PAPOLA poly(A) polymerase alpha 0.0150261
ARRDC3 arrestin domain containing 3 0.0149865
ABI1 abl-interactor 1 0.0149537
BIRC3 baculoviral IAP repeat containing 3 0.0144984
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0144852
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0143828
AHNAK AHNAK nucleoprotein 0.0143021
LRRC1 leucine rich repeat containing 1 0.0142913
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0140696
CD109 CD109 molecule 0.0140538
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0140278
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0139832
PGK1 phosphoglycerate kinase 1 0.0138131
MYO5B myosin VB 0.0137953
UGCG UDP-glucose ceramide glucosyltransferase 0.0137431
DSCAM Down syndrome cell adhesion molecule 0.0135279
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0134951
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0133376

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.211922
FTL ferritin, light polypeptide -0.211476
ACTG1 actin gamma 1 -0.147229
TMSB10 thymosin beta 10 -0.140515
PTMA prothymosin, alpha -0.126346
ALCAM activated leukocyte cell adhesion molecule -0.0746906
RPLP1 ribosomal protein, large, P1 -0.072309
RPL35A ribosomal protein L35a -0.0704972
TPT1 tumor protein, translationally-controlled 1 -0.0625814
EIF1 eukaryotic translation initiation factor 1 -0.0596252
TM4SF1 transmembrane 4 L six family member 1 -0.0591705
S100A6 S100 calcium binding protein A6 -0.0581229
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0577418
RPL34 ribosomal protein L34 -0.0555852
RPL8 ribosomal protein L8 -0.0529784
RPS8 ribosomal protein S8 -0.0524728
RPS19 ribosomal protein S19 -0.0524189
TMSB4X thymosin beta 4, X-linked -0.0519314
RPS6 ribosomal protein S6 -0.0484244
S100A10 S100 calcium binding protein A10 -0.0476876
SLC38A1 solute carrier family 38, member 1 -0.0470585
CSTB cystatin B (stefin B) -0.046125
ISG15 ISG15 ubiquitin-like modifier -0.0438871
RAB7A RAB7A, member RAS oncogene family -0.043364
LMO7 LIM domain 7 -0.043159
IFI27 interferon, alpha-inducible protein 27 -0.0421388
FBXO32 F-box protein 32 -0.041203
IFITM3 interferon induced transmembrane protein 3 -0.0408976
IGFBP3 insulin-like growth factor binding protein 3 -0.0405431
GOLGA4 golgin A4 -0.0393097
NPEPPS aminopeptidase puromycin sensitive -0.0384861
CCND1 cyclin D1 -0.0364893
MT2A metallothionein 2A -0.0359799
TPM4 tropomyosin 4 -0.0359556
VIM vimentin -0.0357785
RPL19 ribosomal protein L19 -0.0357686
RPL37A ribosomal protein L37a -0.035298
RPL30 ribosomal protein L30 -0.0350481
RBM25 RNA binding motif protein 25 -0.0343852
RPLP2 ribosomal protein, large, P2 -0.0342272
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0341071
RPS29 ribosomal protein S29 -0.0339261
SOX4 SRY (sex determining region Y)-box 4 -0.0332722
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0332365
IFITM1 interferon induced transmembrane protein 1 -0.0330238
ANXA2 annexin A2 -0.0326665
KRT7 keratin 7, type II -0.032308
RPL28 ribosomal protein L28 -0.0314365
RPS3 ribosomal protein S3 -0.0313242
RPL32 ribosomal protein L32 -0.0308698
GNAS GNAS complex locus -0.0306258
EPCAM epithelial cell adhesion molecule -0.0305001
LMNA lamin A/C -0.0303963
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0298056
MXD1 MAX dimerization protein 1 -0.0294722
S100A9 S100 calcium binding protein A9 -0.0290792
IFI6 interferon, alpha-inducible protein 6 -0.028746
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0286383
RPL37 ribosomal protein L37 -0.0285114
RPS27 ribosomal protein S27 -0.0283886
KMT2E lysine (K)-specific methyltransferase 2E -0.0280045
RPS14 ribosomal protein S14 -0.0279848
RPL23 ribosomal protein L23 -0.0279221
RACK1 receptor for activated C kinase 1 -0.0276298
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0275176
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0273428
JMJD1C jumonji domain containing 1C -0.0272891
RPS13 ribosomal protein S13 -0.0272321
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0271752
CCNI cyclin I -0.0271504
LOC112694756 uncharaterized LOC112694756 -0.0269806
BASP1 brain abundant, membrane attached signal protein 1 -0.0267813
ACBD3 acyl-CoA binding domain containing 3 -0.026431
RPL27A ribosomal protein L27a -0.0259917
NIPBL Nipped-B homolog (Drosophila) -0.0258872
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0256472
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0255251
RPLP0 ribosomal protein, large, P0 -0.0253991
RPL36 ribosomal protein L36 -0.0253814
TMEM263 transmembrane protein 263 -0.0252488
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.025225
RPS21 ribosomal protein S21 -0.0251947
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0251053
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.024971
DEK DEK proto-oncogene -0.024751
RPS27A ribosomal protein S27a -0.0246901
TMEM165 transmembrane protein 165 -0.0243878
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0243087
RPL11 ribosomal protein L11 -0.0239813
NPC2 Niemann-Pick disease, type C2 -0.0236145
PLAU plasminogen activator, urokinase -0.0233548
RPS5 ribosomal protein S5 -0.0232919
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0227386
RPS24 ribosomal protein S24 -0.0226304
TPI1 triosephosphate isomerase 1 -0.0225506
RPL12 ribosomal protein L12 -0.0225174
KPNB1 karyopherin (importin) beta 1 -0.0220842
CD2AP CD2-associated protein -0.0220567
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0216675
SH3KBP1 SH3-domain kinase binding protein 1 -0.0215273