| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCBP2 | poly(rC) binding protein 2 | 0.153177 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.141786 |
| FN1 | fibronectin 1 | 0.134849 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.134083 |
| FNDC3B | fibronectin type III domain containing 3B | 0.125901 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.123984 |
| MYOF | myoferlin | 0.107721 |
| MCL1 | myeloid cell leukemia 1 | 0.0960104 |
| CD109 | CD109 molecule | 0.0836461 |
| PGK1 | phosphoglycerate kinase 1 | 0.0808125 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0798942 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0789143 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0786687 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0744626 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0744257 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0729095 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0708275 |
| STC2 | stanniocalcin 2 | 0.07078 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0673609 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0672676 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0648156 |
| CDH13 | cadherin 13 | 0.059921 |
| GDA | guanine deaminase | 0.0599126 |
| NRCAM | neuronal cell adhesion molecule | 0.0598189 |
| ENO1 | enolase 1, (alpha) | 0.0589192 |
| COL5A2 | collagen, type V, alpha 2 | 0.0588932 |
| PCBP3 | poly(rC) binding protein 3 | 0.0584183 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0564284 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0558108 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0548924 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0542223 |
| RPL3 | ribosomal protein L3 | 0.0540949 |
| TMSB10 | thymosin beta 10 | 0.0509394 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0506511 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0497001 |
| PTEN | phosphatase and tensin homolog | 0.0483114 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0476212 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0462295 |
| DNER | delta/notch-like EGF repeat containing | 0.0456321 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0454307 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0449166 |
| FTL | ferritin, light polypeptide | 0.0447569 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0445031 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0431052 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0416096 |
| CALR | calreticulin | 0.0412426 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0406611 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0405747 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0404234 |
| RPS18 | ribosomal protein S18 | 0.0403897 |
| LDHA | lactate dehydrogenase A | 0.0397557 |
| TXNRD1 | thioredoxin reductase 1 | 0.0393702 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0386272 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0381373 |
| PRKD3 | protein kinase D3 | 0.0378983 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0372998 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.037239 |
| ASPH | aspartate beta-hydroxylase | 0.0371264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0370365 |
| SQSTM1 | sequestosome 1 | 0.0359037 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0356233 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.035598 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.034611 |
| CTBP2 | C-terminal binding protein 2 | 0.0345673 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0341217 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0339993 |
| HLA-A | major histocompatibility complex, class I, A | 0.0331191 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0322255 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0321419 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0319853 |
| NHSL1 | NHS-like 1 | 0.0311775 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0307749 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0307571 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0307455 |
| FAM13A | family with sequence similarity 13, member A | 0.0305686 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0303507 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0293282 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292323 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0288511 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0279601 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0279589 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0276937 |
| RNF145 | ring finger protein 145 | 0.0274834 |
| ATXN1 | ataxin 1 | 0.027162 |
| PTMA | prothymosin, alpha | 0.0268533 |
| ANXA2 | annexin A2 | 0.0268436 |
| TBXT | T-box transcription factor T | 0.0268291 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0263808 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0263604 |
| MB21D2 | Mab-21 domain containing 2 | 0.0258432 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0257676 |
| GNAS | GNAS complex locus | 0.0256414 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.025422 |
| HYOU1 | hypoxia up-regulated 1 | 0.0250759 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0249268 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0248545 |
| TPM3 | tropomyosin 3 | 0.0246163 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0245282 |
| NUP58 | nucleoporin 58 | 0.0243326 |
| FLNA | filamin A, alpha | 0.0238362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.198439 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.192945 |
| GRAMD1B | GRAM domain containing 1B | -0.119738 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.116 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.1048 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.103657 |
| PDE10A | phosphodiesterase 10A | -0.0989932 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0791256 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0773911 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0635259 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0615769 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0594111 |
| RGS2 | regulator of G-protein signaling 2 | -0.0586861 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0531976 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0522553 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0516513 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.049862 |
| DST | dystonin | -0.0482483 |
| RPS6 | ribosomal protein S6 | -0.0470532 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0465156 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0458113 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0448199 |
| PLCB4 | phospholipase C, beta 4 | -0.0425194 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.042432 |
| ACTG1 | actin gamma 1 | -0.0423261 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0411779 |
| RPS24 | ribosomal protein S24 | -0.0410136 |
| RPS2 | ribosomal protein S2 | -0.0406598 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0406294 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0390905 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0382365 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0379899 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0347181 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0345036 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0338059 |
| RPL36A | ribosomal protein L36a | -0.0330601 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0325256 |
| BPTF | bromodomain PHD finger transcription factor | -0.0322672 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0309876 |
| RPLP1 | ribosomal protein, large, P1 | -0.0308277 |
| MT2A | metallothionein 2A | -0.0301177 |
| RPS8 | ribosomal protein S8 | -0.0300257 |
| CD44 | CD44 molecule (Indian blood group) | -0.029553 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0285206 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0284988 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0280504 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0276251 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0275976 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0275492 |
| VDAC1 | voltage-dependent anion channel 1 | -0.027446 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.026987 |
| PALLD | palladin, cytoskeletal associated protein | -0.0265736 |
| RPL26 | ribosomal protein L26 | -0.0262723 |
| CEP350 | centrosomal protein 350kDa | -0.025117 |
| DISP1 | dispatched homolog 1 (Drosophila) | -0.024965 |
| EXOC6B | exocyst complex component 6B | -0.0248907 |
| RPL7A | ribosomal protein L7a | -0.0247411 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0247294 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0243897 |
| OSMR | oncostatin M receptor | -0.0234011 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0233798 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0233521 |
| PCED1B | PC-esterase domain containing 1B | -0.0231373 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0230255 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0229711 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0229461 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0229145 |
| NABP1 | nucleic acid binding protein 1 | -0.0225948 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0223596 |
| EPHA4 | EPH receptor A4 | -0.022151 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0221262 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0216167 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0212532 |
| RPL6 | ribosomal protein L6 | -0.0212303 |
| S100A10 | S100 calcium binding protein A10 | -0.021141 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0210166 |
| CCDC68 | coiled-coil domain containing 68 | -0.0209759 |
| KIAA0825 | KIAA0825 | -0.0208851 |
| RPS23 | ribosomal protein S23 | -0.020398 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0203303 |
| MYO9A | myosin IXA | -0.020329 |
| RPL39 | ribosomal protein L39 | -0.0202656 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0202617 |
| HDAC4 | histone deacetylase 4 | -0.0201967 |
| RASAL2 | RAS protein activator like 2 | -0.0201744 |
| RPL38 | ribosomal protein L38 | -0.0201127 |
| SRPK2 | SRSF protein kinase 2 | -0.020083 |
| RPS21 | ribosomal protein S21 | -0.0200719 |
| RPLP2 | ribosomal protein, large, P2 | -0.019969 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0199283 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0199171 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0197509 |
| OXSR1 | oxidative stress responsive 1 | -0.0197261 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0197204 |
| RPS16 | ribosomal protein S16 | -0.019701 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0193852 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0192815 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0192812 |
| RPLP0 | ribosomal protein, large, P0 | -0.0191702 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0190737 |
