Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H596 Gene Set
Genes
62 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
APP
|
amyloid beta (A4) precursor protein
|
0.208629
|
|
ZFAND3
|
zinc finger, AN1-type domain 3
|
0.198491
|
|
LPP
|
LIM domain containing preferred translocation partner in lipoma
|
0.19222
|
|
SMAD2
|
SMAD family member 2
|
0.157189
|
|
MED13
|
mediator complex subunit 13
|
0.154978
|
|
ESYT2
|
extended synaptotagmin-like protein 2
|
0.154725
|
|
RAB6A
|
RAB6A, member RAS oncogene family
|
0.145732
|
|
TRIO
|
trio Rho guanine nucleotide exchange factor
|
0.133078
|
|
EFNA5
|
ephrin-A5
|
0.128542
|
|
PICALM
|
phosphatidylinositol binding clathrin assembly protein
|
0.117581
|
|
CD55
|
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
|
0.102256
|
|
ASPH
|
aspartate beta-hydroxylase
|
0.100055
|
|
PKM
|
pyruvate kinase, muscle
|
0.0845847
|
|
ATXN1
|
ataxin 1
|
0.0766417
|
|
RPS6
|
ribosomal protein S6
|
0.0760619
|
|
SLC2A3
|
solute carrier family 2 (facilitated glucose transporter), member 3
|
0.0754985
|
|
RTN4
|
reticulon 4
|
0.068638
|
|
AGAP1
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
|
0.0677146
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
0.0642839
|
|
PDE4D
|
phosphodiesterase 4D, cAMP-specific
|
0.0611522
|
|
EPS8
|
epidermal growth factor receptor pathway substrate 8
|
0.0553378
|
|
PARD3
|
par-3 family cell polarity regulator
|
0.054952
|
|
GSE1
|
Gse1 coiled-coil protein
|
0.052541
|
|
DSCAM
|
Down syndrome cell adhesion molecule
|
0.0446553
|
|
NDRG1
|
N-myc downstream regulated 1
|
0.0243307
|
|
TXNRD1
|
thioredoxin reductase 1
|
0.0206609
|
|
ERO1A
|
endoplasmic reticulum oxidoreductase 1 alpha
|
0.0171537
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
FN1
|
fibronectin 1
|
-0.245152
|
|
TPT1
|
tumor protein, translationally-controlled 1
|
-0.220603
|
|
HSP90AA1
|
heat shock protein 90kDa alpha (cytosolic), class A member 1
|
-0.192498
|
|
VIM
|
vimentin
|
-0.131085
|
|
HMGA2
|
high mobility group AT-hook 2
|
-0.124357
|
|
AKAP12
|
A kinase (PRKA) anchor protein 12
|
-0.110748
|
|
FTL
|
ferritin, light polypeptide
|
-0.105159
|
|
RPS16
|
ribosomal protein S16
|
-0.104615
|
|
CXCL8
|
chemokine (C-X-C motif) ligand 8
|
-0.102648
|
|
EGFR
|
epidermal growth factor receptor
|
-0.0932811
|
|
RPS19
|
ribosomal protein S19
|
-0.0887267
|
|
NPAS2
|
neuronal PAS domain protein 2
|
-0.0841074
|
|
EXT1
|
exostosin glycosyltransferase 1
|
-0.0799408
|
|
CADM2
|
cell adhesion molecule 2
|
-0.0793379
|
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.0724618
|
|
ZNF292
|
zinc finger protein 292
|
-0.0723002
|
|
PABPC1
|
poly(A) binding protein, cytoplasmic 1
|
-0.062847
|
|
TMSB10
|
thymosin beta 10
|
-0.052821
|
|
HSP90B1
|
heat shock protein 90kDa beta (Grp94), member 1
|
-0.0499476
|
|
GOLGA4
|
golgin A4
|
-0.0495441
|
|
RPS12
|
ribosomal protein S12
|
-0.0480621
|
|
GPC6
|
glypican 6
|
-0.0437612
|
|
HSP90AB1
|
heat shock protein 90kDa alpha (cytosolic), class B member 1
|
-0.0426903
|
|
ITGB1
|
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
|
-0.0354716
|
|
HSPA5
|
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
|
-0.0348383
|
|
RPL31
|
ribosomal protein L31
|
-0.0294809
|
|
NAP1L1
|
nucleosome assembly protein 1-like 1
|
-0.0288209
|
|
PRKCA
|
protein kinase C, alpha
|
-0.0257954
|
|
IMMP2L
|
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
|
-0.0232613
|
|
IGFBP5
|
insulin-like growth factor binding protein 5
|
-0.0188346
|
|
PTMA
|
prothymosin, alpha
|
-0.0161812
|
|
ZMYND8
|
zinc finger, MYND-type containing 8
|
-0.00900284
|
|
PGK1
|
phosphoglycerate kinase 1
|
-0.00834114
|
|
PALM2AKAP2
|
PALM2 and AKAP2 fusion
|
-0.00702841
|
|
LDHA
|
lactate dehydrogenase A
|
-0.00296749
|
