| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.266899 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.195214 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.130376 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.129834 |
| FNDC3B | fibronectin type III domain containing 3B | 0.12743 |
| SEPTIN9 | septin 9 | 0.113572 |
| SMAD3 | SMAD family member 3 | 0.103055 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0973229 |
| NAV2 | neuron navigator 2 | 0.0940712 |
| FMNL2 | formin-like 2 | 0.0924565 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.091245 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0830181 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0809942 |
| ZFP36 | ZFP36 ring finger protein | 0.0768595 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0765278 |
| PCBP2 | poly(rC) binding protein 2 | 0.0752867 |
| AFAP1 | actin filament associated protein 1 | 0.0720681 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0703735 |
| MYOF | myoferlin | 0.0677297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.064477 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0629029 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0621514 |
| FBL | fibrillarin | 0.0620274 |
| CTBP2 | C-terminal binding protein 2 | 0.0609626 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0586555 |
| PDE10A | phosphodiesterase 10A | 0.0576937 |
| MSN | moesin | 0.0574819 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0561216 |
| PTK2 | protein tyrosine kinase 2 | 0.0558493 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0553989 |
| SPAG9 | sperm associated antigen 9 | 0.0553573 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0550733 |
| CDK19 | cyclin-dependent kinase 19 | 0.0542702 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0522329 |
| ENO1 | enolase 1, (alpha) | 0.0516952 |
| ATP13A3 | ATPase type 13A3 | 0.0511504 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.050478 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0502241 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0495358 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.049109 |
| CD109 | CD109 molecule | 0.0473138 |
| HMGA1 | high mobility group AT-hook 1 | 0.0471613 |
| PKM | pyruvate kinase, muscle | 0.0470835 |
| DST | dystonin | 0.0470335 |
| MED13L | mediator complex subunit 13-like | 0.046871 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0461078 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0439634 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0436864 |
| TNS3 | tensin 3 | 0.0431418 |
| UBC | ubiquitin C | 0.0430016 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0427282 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.042168 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0413636 |
| APP | amyloid beta (A4) precursor protein | 0.0412447 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0410449 |
| MYO10 | myosin X | 0.0405451 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0403242 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0389997 |
| HPCAL1 | hippocalcin-like 1 | 0.0388421 |
| XPO1 | exportin 1 | 0.0385917 |
| JMJD1C | jumonji domain containing 1C | 0.0384777 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0384273 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0383636 |
| ZNF292 | zinc finger protein 292 | 0.0382783 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0381485 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.038041 |
| LDHA | lactate dehydrogenase A | 0.0373381 |
| TPM3 | tropomyosin 3 | 0.0369147 |
| YAP1 | Yes-associated protein 1 | 0.0368381 |
| POTEF | POTE ankyrin domain family, member F | 0.0367734 |
| MCL1 | myeloid cell leukemia 1 | 0.0367047 |
| AHNAK | AHNAK nucleoprotein | 0.0362934 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0362213 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0358709 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0358312 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0353362 |
| NHSL1 | NHS-like 1 | 0.0353088 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0352551 |
| L1CAM | L1 cell adhesion molecule | 0.0350161 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0349153 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0348455 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0346803 |
| RNF220 | ring finger protein 220 | 0.0343561 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0342786 |
| CMIP | c-Maf inducing protein | 0.0340294 |
| TMEM123 | transmembrane protein 123 | 0.0338202 |
| MEF2A | myocyte enhancer factor 2A | 0.0333351 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0332514 |
| FLNB | filamin B, beta | 0.0327139 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0324977 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0324321 |
| ATXN1 | ataxin 1 | 0.0323747 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0323573 |
| SNX14 | sorting nexin 14 | 0.0323334 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.0321996 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.031849 |
| AFDN | afadin, adherens junction formation factor | 0.0314045 |
| RTN4 | reticulon 4 | 0.0313366 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0312921 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0312317 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS16 | ribosomal protein S16 | -0.154734 |
| VCL | vinculin | -0.144402 |
| RPLP1 | ribosomal protein, large, P1 | -0.0595021 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0524293 |
| VIM | vimentin | -0.0474866 |
| TMSB10 | thymosin beta 10 | -0.0467533 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0455756 |
| RPS3 | ribosomal protein S3 | -0.0423948 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0423098 |
| MT2A | metallothionein 2A | -0.0407513 |
| ACTG1 | actin gamma 1 | -0.0347681 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0346883 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0345017 |
| RPL26 | ribosomal protein L26 | -0.0342632 |
| RPS12 | ribosomal protein S12 | -0.0338795 |
| ZNF780B | zinc finger protein 780B | -0.03376 |
| RPL37A | ribosomal protein L37a | -0.032681 |
| EGR1 | early growth response 1 | -0.0325995 |
| RPL35A | ribosomal protein L35a | -0.0299989 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0286594 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0285427 |
| RPL12 | ribosomal protein L12 | -0.0284506 |
| SAMD4B | sterile alpha motif domain containing 4B | -0.0284295 |
| CD44 | CD44 molecule (Indian blood group) | -0.027864 |
| FHL2 | four and a half LIM domains 2 | -0.0273319 |
| RPS8 | ribosomal protein S8 | -0.0271406 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0262512 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0259209 |
| RPS19 | ribosomal protein S19 | -0.0251516 |
| RPLP2 | ribosomal protein, large, P2 | -0.0250257 |
| RPS27 | ribosomal protein S27 | -0.0246368 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0240964 |
| RPL11 | ribosomal protein L11 | -0.0228898 |
| PHF14 | PHD finger protein 14 | -0.0227701 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0226238 |
| KLF6 | Kruppel-like factor 6 | -0.0223398 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0223104 |
| RPL30 | ribosomal protein L30 | -0.0215378 |
| RPL36 | ribosomal protein L36 | -0.021427 |
| VDAC1 | voltage-dependent anion channel 1 | -0.021369 |
| RACK1 | receptor for activated C kinase 1 | -0.0213281 |
| INTS6 | integrator complex subunit 6 | -0.0209044 |
| RPL31 | ribosomal protein L31 | -0.0208344 |
| ATF6 | activating transcription factor 6 | -0.020317 |
| RPS27A | ribosomal protein S27a | -0.0201291 |
| MYO9A | myosin IXA | -0.0197141 |
| RPL28 | ribosomal protein L28 | -0.0196367 |
| RPL4 | ribosomal protein L4 | -0.0194251 |
| FTL | ferritin, light polypeptide | -0.0189585 |
| NUP98 | nucleoporin 98kDa | -0.0189267 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0180115 |
| NABP1 | nucleic acid binding protein 1 | -0.0176905 |
| RPS24 | ribosomal protein S24 | -0.0176267 |
| RPL35 | ribosomal protein L35 | -0.0173853 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0173407 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0173325 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0173214 |
| OSMR | oncostatin M receptor | -0.0173207 |
| RPL37 | ribosomal protein L37 | -0.0170264 |
| RASAL2 | RAS protein activator like 2 | -0.0170105 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0167103 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0166381 |
| MED29 | mediator complex subunit 29 | -0.0165945 |
| TBCA | tubulin folding cofactor A | -0.0165885 |
| RPL34 | ribosomal protein L34 | -0.0163845 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0161302 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0158604 |
| RPL7 | ribosomal protein L7 | -0.0157494 |
| TMEM41B | transmembrane protein 41B | -0.015687 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0150579 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0147457 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0145551 |
| BPTF | bromodomain PHD finger transcription factor | -0.0144957 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0144489 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0143711 |
| RPLP0 | ribosomal protein, large, P0 | -0.0143214 |
| RPS5 | ribosomal protein S5 | -0.0141705 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.0141516 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0140622 |
| RPS6 | ribosomal protein S6 | -0.014044 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0139487 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0139368 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.013917 |
| ZNF546 | zinc finger protein 546 | -0.0138679 |
| RPL32 | ribosomal protein L32 | -0.0137984 |
| RPL23 | ribosomal protein L23 | -0.0137786 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0137223 |
| CDK13 | cyclin-dependent kinase 13 | -0.0135687 |
| IER3 | immediate early response 3 | -0.0135339 |
| RPS2 | ribosomal protein S2 | -0.01349 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0133499 |
| RPL19 | ribosomal protein L19 | -0.013298 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0132387 |
| RPL18 | ribosomal protein L18 | -0.0131479 |
| CAVIN1 | caveolae associated protein 1 | -0.0131408 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.013137 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.01307 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0130571 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0130474 |
| YBX3 | Y box binding protein 3 | -0.0129911 |
