| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCBP2 | poly(rC) binding protein 2 | 0.127266 |
| FNDC3B | fibronectin type III domain containing 3B | 0.105238 |
| NDRG1 | N-myc downstream regulated 1 | 0.100703 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.086685 |
| MUC4 | mucin 4, cell surface associated | 0.0863032 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0783374 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0737292 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0726114 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0713481 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0696986 |
| PGK1 | phosphoglycerate kinase 1 | 0.0693457 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0665988 |
| SMAD3 | SMAD family member 3 | 0.066388 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0652015 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0644023 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.064228 |
| TXNIP | thioredoxin interacting protein | 0.0634456 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0614236 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0610086 |
| RNF213 | ring finger protein 213 | 0.0607024 |
| AFDN | afadin, adherens junction formation factor | 0.0570912 |
| B2M | beta-2-microglobulin | 0.0564061 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0563562 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0561716 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0553247 |
| CALR | calreticulin | 0.0552093 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0542999 |
| RPS18 | ribosomal protein S18 | 0.0540705 |
| MEF2A | myocyte enhancer factor 2A | 0.052799 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0525902 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0518306 |
| FMNL2 | formin-like 2 | 0.0512737 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.050868 |
| ANXA11 | annexin A11 | 0.0502123 |
| TPM3 | tropomyosin 3 | 0.0501107 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.048561 |
| C3 | complement component 3 | 0.0482167 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.048122 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0479953 |
| PTK2 | protein tyrosine kinase 2 | 0.0476078 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0468882 |
| DSPP | dentin sialophosphoprotein | 0.0459866 |
| XPO1 | exportin 1 | 0.0455495 |
| ATP13A3 | ATPase type 13A3 | 0.044377 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0440812 |
| FLNB | filamin B, beta | 0.0438725 |
| KRT7 | keratin 7, type II | 0.0424787 |
| PKM | pyruvate kinase, muscle | 0.0421768 |
| AHNAK | AHNAK nucleoprotein | 0.0421297 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0416107 |
| ASPH | aspartate beta-hydroxylase | 0.041596 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0415516 |
| APP | amyloid beta (A4) precursor protein | 0.0413911 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0413712 |
| SLMAP | sarcolemma associated protein | 0.0412561 |
| POTEF | POTE ankyrin domain family, member F | 0.040824 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0405541 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0403615 |
| LDHA | lactate dehydrogenase A | 0.0399178 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0397791 |
| MX1 | MX dynamin-like GTPase 1 | 0.0396159 |
| VEGFA | vascular endothelial growth factor A | 0.0396048 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0389078 |
| HMGA1 | high mobility group AT-hook 1 | 0.0387572 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0386778 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.038156 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0379226 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0378009 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0377863 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0376735 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0375937 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0373385 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0372825 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0368623 |
| TGM2 | transglutaminase 2 | 0.0367262 |
| CCNY | cyclin Y | 0.0362555 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.036088 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0359956 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0356934 |
| PDS5B | PDS5 cohesin associated factor B | 0.0356078 |
| KRT19 | keratin 19, type I | 0.0350728 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.034358 |
| RPL3 | ribosomal protein L3 | 0.0342343 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0339773 |
| NAV2 | neuron navigator 2 | 0.0336942 |
| CD2AP | CD2-associated protein | 0.0333649 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0332634 |
| CCNL1 | cyclin L1 | 0.0329742 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0323659 |
| KRT8 | keratin 8, type II | 0.0322739 |
| ZNF292 | zinc finger protein 292 | 0.0321055 |
| RREB1 | ras responsive element binding protein 1 | 0.0320928 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0319806 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.031659 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0315439 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0313109 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.03126 |
| JUP | junction plakoglobin | 0.0311232 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0311202 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0310415 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.230755 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.108127 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0743931 |
| GOLGB1 | golgin B1 | -0.0709424 |
| RPS6 | ribosomal protein S6 | -0.0671584 |
| RPLP1 | ribosomal protein, large, P1 | -0.061772 |
| RPL35A | ribosomal protein L35a | -0.0578886 |
| ACTG1 | actin gamma 1 | -0.0564549 |
| INTS6 | integrator complex subunit 6 | -0.0551807 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.054819 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0519287 |
| RPS8 | ribosomal protein S8 | -0.0486304 |
| EGR1 | early growth response 1 | -0.0434969 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0431135 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0425935 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0412477 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0410086 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0406697 |
| EMP1 | epithelial membrane protein 1 | -0.0402228 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0396395 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0378715 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0375703 |
| RPL8 | ribosomal protein L8 | -0.0362769 |
| TJP1 | tight junction protein 1 | -0.0358504 |
| RPL23 | ribosomal protein L23 | -0.0356233 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0353731 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0348204 |
| RPS15 | ribosomal protein S15 | -0.0339167 |
| RPS24 | ribosomal protein S24 | -0.0333055 |
| RPS19 | ribosomal protein S19 | -0.0327524 |
| RPL34 | ribosomal protein L34 | -0.0321935 |
| HDAC9 | histone deacetylase 9 | -0.0311274 |
| SQSTM1 | sequestosome 1 | -0.0309297 |
| LAMA4 | laminin, alpha 4 | -0.0309283 |
| INHBA | inhibin, beta A | -0.0306586 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0305197 |
| PATJ | PATJ crumbs cell polarity complex component | -0.030471 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.03044 |
| SIK3 | SIK family kinase 3 | -0.0300207 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0295569 |
| VCL | vinculin | -0.0293151 |
| MT2A | metallothionein 2A | -0.0280774 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0279757 |
| RPS27A | ribosomal protein S27a | -0.0274356 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0272591 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0266787 |
| RPS16 | ribosomal protein S16 | -0.02666 |
| ZDHHC13 | zinc finger, DHHC-type containing 13 | -0.0266583 |
| DIAPH3 | diaphanous-related formin 3 | -0.0265929 |
| EGFR | epidermal growth factor receptor | -0.0263742 |
| RACK1 | receptor for activated C kinase 1 | -0.0262991 |
| ABHD3 | abhydrolase domain containing 3 | -0.025977 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0256813 |
| RPL28 | ribosomal protein L28 | -0.0256437 |
| FTL | ferritin, light polypeptide | -0.0255846 |
| RPL30 | ribosomal protein L30 | -0.0254614 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0252475 |
| RPL19 | ribosomal protein L19 | -0.0251335 |
| RPL12 | ribosomal protein L12 | -0.0249702 |
| MYO1E | myosin IE | -0.0248879 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0245463 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0244922 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0244474 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0243708 |
| GPHN | gephyrin | -0.0242628 |
| RPL37A | ribosomal protein L37a | -0.0240898 |
| CEP350 | centrosomal protein 350kDa | -0.0236332 |
| NABP1 | nucleic acid binding protein 1 | -0.0235577 |
| TBCA | tubulin folding cofactor A | -0.0234591 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.023244 |
| RPS13 | ribosomal protein S13 | -0.0231271 |
| RPLP0 | ribosomal protein, large, P0 | -0.0228943 |
| RASAL2 | RAS protein activator like 2 | -0.0226543 |
| TGFB2 | transforming growth factor, beta 2 | -0.0224567 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0223305 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0223067 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0221782 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0221211 |
| S100A9 | S100 calcium binding protein A9 | -0.0220983 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0220603 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0218735 |
| RPS14 | ribosomal protein S14 | -0.0216371 |
| RPS21 | ribosomal protein S21 | -0.0213116 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0212586 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0212476 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0211813 |
| CLDN1 | claudin 1 | -0.0210424 |
| ANXA2 | annexin A2 | -0.0207965 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.020581 |
| RPS27 | ribosomal protein S27 | -0.020487 |
| CDK13 | cyclin-dependent kinase 13 | -0.0203466 |
| RPL39 | ribosomal protein L39 | -0.0203434 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0201551 |
| HLA-E | major histocompatibility complex, class I, E | -0.0201245 |
| RPL32 | ribosomal protein L32 | -0.0200225 |
| RPS3 | ribosomal protein S3 | -0.0199001 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0198953 |
| RPS5 | ribosomal protein S5 | -0.0196978 |
| RPL36AL | ribosomal protein L36a-like | -0.0196446 |
| RPS29 | ribosomal protein S29 | -0.0195745 |
