| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.120182 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.118552 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.101975 |
| RPL3 | ribosomal protein L3 | 0.0912306 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0869307 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0859582 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0846566 |
| FLNB | filamin B, beta | 0.0836254 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0829953 |
| MCL1 | myeloid cell leukemia 1 | 0.0818107 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0817015 |
| ZNF292 | zinc finger protein 292 | 0.0803105 |
| HMGA1 | high mobility group AT-hook 1 | 0.0777662 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0732162 |
| NAV2 | neuron navigator 2 | 0.0722877 |
| PCBP2 | poly(rC) binding protein 2 | 0.0716249 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0700387 |
| PGK1 | phosphoglycerate kinase 1 | 0.0698993 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0647704 |
| NUP58 | nucleoporin 58 | 0.0646524 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0645645 |
| RPS18 | ribosomal protein S18 | 0.0643576 |
| NDRG1 | N-myc downstream regulated 1 | 0.0637039 |
| ENO1 | enolase 1, (alpha) | 0.0636448 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0620201 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0616031 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0597191 |
| TPD52 | tumor protein D52 | 0.058998 |
| PKM | pyruvate kinase, muscle | 0.0580869 |
| FMNL2 | formin-like 2 | 0.0578741 |
| LAMB3 | laminin, beta 3 | 0.0569796 |
| USP3 | ubiquitin specific peptidase 3 | 0.0567091 |
| PTK2 | protein tyrosine kinase 2 | 0.0565288 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0554813 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0551153 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0550781 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0548306 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.052758 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0525007 |
| ATP13A3 | ATPase type 13A3 | 0.0523604 |
| FHIT | fragile histidine triad | 0.052305 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0521229 |
| RAD51B | RAD51 paralog B | 0.0513263 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0509184 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0508327 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0507753 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0502626 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0495993 |
| WDR43 | WD repeat domain 43 | 0.0485239 |
| CORO1C | coronin, actin binding protein, 1C | 0.0484367 |
| XPO1 | exportin 1 | 0.0469958 |
| BBX | bobby sox homolog (Drosophila) | 0.0463866 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0458775 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0456415 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0455983 |
| PARD3 | par-3 family cell polarity regulator | 0.0455362 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0454866 |
| APP | amyloid beta (A4) precursor protein | 0.0451388 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.04444 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0437259 |
| UBC | ubiquitin C | 0.0432983 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0431353 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0430355 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0415921 |
| TPM3 | tropomyosin 3 | 0.0412569 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0412468 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0410223 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0405807 |
| RBM39 | RNA binding motif protein 39 | 0.0403029 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0397861 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0394452 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0393171 |
| HELZ | helicase with zinc finger | 0.0393002 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0391622 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0387269 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0383126 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0379999 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0378535 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0378226 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0368998 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0367427 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0366785 |
| NBAS | neuroblastoma amplified sequence | 0.0362738 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0354165 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0353893 |
| NCKAP1 | NCK-associated protein 1 | 0.0349778 |
| FAM120A | family with sequence similarity 120A | 0.0348965 |
| TP53BP2 | tumor protein p53 binding protein 2 | 0.0345339 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0345058 |
| YEATS2 | YEATS domain containing 2 | 0.033954 |
| CUL3 | cullin 3 | 0.0336512 |
| SBF2 | SET binding factor 2 | 0.0335564 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0333704 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0332702 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.033009 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0329828 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0328768 |
| TTR | transthyretin | 0.0328156 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0323159 |
| RBM33 | RNA binding motif protein 33 | 0.0322784 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.124985 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0777172 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0684435 |
| NABP1 | nucleic acid binding protein 1 | -0.0614089 |
| ZNF438 | zinc finger protein 438 | -0.0549871 |
| ACTG1 | actin gamma 1 | -0.0452038 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0442507 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0434379 |
| NAV3 | neuron navigator 3 | -0.0430226 |
| RPLP1 | ribosomal protein, large, P1 | -0.0409192 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0377872 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0364463 |
| EGR1 | early growth response 1 | -0.0346844 |
| RPL35A | ribosomal protein L35a | -0.0333759 |
| HMGA2 | high mobility group AT-hook 2 | -0.0327826 |
| SP100 | SP100 nuclear antigen | -0.0326552 |
| TXNRD1 | thioredoxin reductase 1 | -0.0323299 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0317293 |
| TMSB10 | thymosin beta 10 | -0.0302833 |
| INTS6 | integrator complex subunit 6 | -0.0296719 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0289655 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0286219 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0282631 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0278156 |
| AHI1 | Abelson helper integration site 1 | -0.0277234 |
| SGMS2 | sphingomyelin synthase 2 | -0.026621 |
| PCNX4 | pecanex 4 | -0.0265157 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0261177 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0248825 |
| RPL35 | ribosomal protein L35 | -0.0245242 |
| RBM25 | RNA binding motif protein 25 | -0.0244976 |
| EFNB2 | ephrin-B2 | -0.0242177 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0241439 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0239701 |
| RPS19 | ribosomal protein S19 | -0.0234672 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0227958 |
| RPS6 | ribosomal protein S6 | -0.0227005 |
| RPL30 | ribosomal protein L30 | -0.022635 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0224429 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0223305 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0220173 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0217942 |
| HDAC9 | histone deacetylase 9 | -0.0217881 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0212829 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0212608 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0212435 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0210436 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0207451 |
| RPL37A | ribosomal protein L37a | -0.0206851 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0205862 |
| RPL26 | ribosomal protein L26 | -0.0205358 |
| TBCA | tubulin folding cofactor A | -0.0203129 |
| PLSCR1 | phospholipid scramblase 1 | -0.0202852 |
| FRMD6 | FERM domain containing 6 | -0.0202607 |
| KLF10 | Kruppel-like factor 10 | -0.0200718 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0200523 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0198212 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0196313 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0196092 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0195627 |
| RPL8 | ribosomal protein L8 | -0.0191731 |
| RPLP2 | ribosomal protein, large, P2 | -0.0188975 |
| RIGI | RNA sensor RIG-I | -0.0188687 |
| ATF6 | activating transcription factor 6 | -0.0186823 |
| LRRC69 | leucine rich repeat containing 69 | -0.0186699 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0183765 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0181188 |
| GPHN | gephyrin | -0.0181159 |
| TMEM41B | transmembrane protein 41B | -0.0180659 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0180284 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0178523 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0177667 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0177132 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0174916 |
| RPS5 | ribosomal protein S5 | -0.0174854 |
| CD44 | CD44 molecule (Indian blood group) | -0.0174742 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0174505 |
| BPTF | bromodomain PHD finger transcription factor | -0.0171546 |
| ZNF407 | zinc finger protein 407 | -0.0169574 |
| RPL28 | ribosomal protein L28 | -0.016939 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.016872 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0168399 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0168329 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0166923 |
| ZNF432 | zinc finger protein 432 | -0.0166867 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0166573 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.016622 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.016493 |
| NUP214 | nucleoporin 214kDa | -0.0164604 |
| HM13 | histocompatibility (minor) 13 | -0.0164551 |
| NLK | nemo-like kinase | -0.0164523 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0163981 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0163463 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0163389 |
| RPL34 | ribosomal protein L34 | -0.0162072 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0161109 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0160421 |
| EGFR | epidermal growth factor receptor | -0.0160376 |
| S100A2 | S100 calcium binding protein A2 | -0.0159275 |
| MX2 | MX dynamin-like GTPase 2 | -0.0158802 |
