Dapagliflozin ((2S)-1,2-propanediol, hydrate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.226876
FNDC3B fibronectin type III domain containing 3B 0.0853221
CD109 CD109 molecule 0.0692191
PGK1 phosphoglycerate kinase 1 0.0684828
LOXL2 lysyl oxidase-like 2 0.0524882
EXT1 exostosin glycosyltransferase 1 0.051656
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0514313
PDE4D phosphodiesterase 4D, cAMP-specific 0.0463172
TRIO trio Rho guanine nucleotide exchange factor 0.0461064
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0447544
JARID2 jumonji, AT rich interactive domain 2 0.0442623
PSD3 pleckstrin and Sec7 domain containing 3 0.0398146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.037619
MYH9 myosin, heavy chain 9, non-muscle 0.0372709
ATP13A3 ATPase type 13A3 0.0345331
ZFP36L1 ZFP36 ring finger protein-like 1 0.0343587
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0334519
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.031756
ICAM1 intercellular adhesion molecule 1 0.0309455
PCBP2 poly(rC) binding protein 2 0.0302846
TMEM178B transmembrane protein 178B 0.0277882
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0276606
MEF2A myocyte enhancer factor 2A 0.0274242
FAM162A family with sequence similarity 162, member A 0.0271652
TRAM2 translocation associated membrane protein 2 0.0262416
ARHGAP35 Rho GTPase activating protein 35 0.0256466
GRB10 growth factor receptor-bound protein 10 0.0252268
PCBP3 poly(rC) binding protein 3 0.024988
FAM13A family with sequence similarity 13, member A 0.0246834
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0246671
MYOF myoferlin 0.0244549
ADM adrenomedullin 0.0240809
KMT2C lysine (K)-specific methyltransferase 2C 0.0227345
EML5 echinoderm microtubule associated protein like 5 0.0227283
SNAP25 synaptosomal-associated protein, 25kDa 0.0225176
MMP2 matrix metallopeptidase 2 0.0217279
ESYT2 extended synaptotagmin-like protein 2 0.021695
MACF1 microtubule-actin crosslinking factor 1 0.0216322
LPP LIM domain containing preferred translocation partner in lipoma 0.0214821
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.021471
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0214085
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.021365
COL1A2 collagen, type I, alpha 2 0.0209635
ZEB2 zinc finger E-box binding homeobox 2 0.0208126
CADM1 cell adhesion molecule 1 0.0207597
INSIG2 insulin induced gene 2 0.0202729
LARP4B La ribonucleoprotein domain family, member 4B 0.0201382
ERRFI1 ERBB receptor feedback inhibitor 1 0.0201277
CDH13 cadherin 13 0.0199371
UGCG UDP-glucose ceramide glucosyltransferase 0.0196923
RAD23B RAD23 homolog B (S. cerevisiae) 0.0196647
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0195789
SAMD4A sterile alpha motif domain containing 4A 0.0195759
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019385
DLG1 discs, large homolog 1 (Drosophila) 0.019372
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0190772
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0188019
KDM3A lysine (K)-specific demethylase 3A 0.0183384
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0177497
GLIS3 GLIS family zinc finger 3 0.0176266
SOD2 superoxide dismutase 2, mitochondrial 0.0174961
FRMD6 FERM domain containing 6 0.0172912
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0172104
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0172041
HILPDA hypoxia inducible lipid droplet-associated 0.0170364
CORO1C coronin, actin binding protein, 1C 0.0169333
WSB1 WD repeat and SOCS box containing 1 0.0169167
FGFR1 fibroblast growth factor receptor 1 0.0164406
CLIC4 chloride intracellular channel 4 0.0163667
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0163193
PTPRG protein tyrosine phosphatase, receptor type, G 0.0163152
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0161567
ELL2 elongation factor, RNA polymerase II, 2 0.0161131
RAB8B RAB8B, member RAS oncogene family 0.0159976
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0156955
INHBA inhibin, beta A 0.0156458
WNT5A wingless-type MMTV integration site family, member 5A 0.0154241
CTSB cathepsin B 0.0151784
ARL4C ADP-ribosylation factor-like 4C 0.0151351
COL5A1 collagen, type V, alpha 1 0.0151265
TPM4 tropomyosin 4 0.0150991
SAMD9 sterile alpha motif domain containing 9 0.0150447
TENT5A terminal nucleotidyltransferase 5A 0.0150261
CCNL1 cyclin L1 0.0147357
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0147213
RNF213 ring finger protein 213 0.0145725
INSIG1 insulin induced gene 1 0.0144618
FAT1 FAT atypical cadherin 1 0.0144325
CYLD cylindromatosis (turban tumor syndrome) 0.0143765
UBE2H ubiquitin-conjugating enzyme E2H 0.0142942
XPO1 exportin 1 0.0142927
ABI1 abl-interactor 1 0.0142832
COL6A2 collagen, type VI, alpha 2 0.0142747
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0142409
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0140694
PFKP phosphofructokinase, platelet 0.01398
TOP2B topoisomerase (DNA) II beta 180kDa 0.0136846
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0136598
SPAG9 sperm associated antigen 9 0.0135504
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0134895

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.212609
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157271
MT2A metallothionein 2A -0.0990232
TMSB10 thymosin beta 10 -0.0728024
CD44 CD44 molecule (Indian blood group) -0.0497768
RPS27A ribosomal protein S27a -0.0497118
STC1 stanniocalcin 1 -0.0481358
RPLP1 ribosomal protein, large, P1 -0.046387
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.043005
UBC ubiquitin C -0.0422681
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0416441
ASPH aspartate beta-hydroxylase -0.0413526
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0404872
HLA-B major histocompatibility complex, class I, B -0.0390676
RPS6 ribosomal protein S6 -0.0387581
FTL ferritin, light polypeptide -0.0384771
RPL37A ribosomal protein L37a -0.0372906
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0366382
B2M beta-2-microglobulin -0.0316735
TFPI2 tissue factor pathway inhibitor 2 -0.030745
PKM pyruvate kinase, muscle -0.0303683
RPS19 ribosomal protein S19 -0.0300364
PDIA3 protein disulfide isomerase family A, member 3 -0.0293101
RPS17 ribosomal protein S17 -0.0291964
RPL35A ribosomal protein L35a -0.0271013
RPS12 ribosomal protein S12 -0.0254278
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.02528
DOCK5 dedicator of cytokinesis 5 -0.0239214
WWTR1 WW domain containing transcription regulator 1 -0.0236836
RPS21 ribosomal protein S21 -0.0228637
FRMD4A FERM domain containing 4A -0.0219547
ZNFX1 zinc finger, NFX1-type containing 1 -0.021564
RPS13 ribosomal protein S13 -0.0214458
RHOA ras homolog family member A -0.0209566
CALU calumenin -0.0208156
PTMA prothymosin, alpha -0.0207697
RPL26 ribosomal protein L26 -0.0205304
RAB2A RAB2A, member RAS oncogene family -0.020374
HM13 histocompatibility (minor) 13 -0.0202944
TOP1 topoisomerase (DNA) I -0.0201306
IER3 immediate early response 3 -0.0199907
RPL23 ribosomal protein L23 -0.0198613
RPS8 ribosomal protein S8 -0.0195626
HMGA2 high mobility group AT-hook 2 -0.0195184
RPL30 ribosomal protein L30 -0.019504
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0195017
CDCP1 CUB domain containing protein 1 -0.0193832
ACTN4 actinin, alpha 4 -0.0192362
RPL37 ribosomal protein L37 -0.0191886
MBD5 methyl-CpG binding domain protein 5 -0.0190003
LOC112694756 uncharaterized LOC112694756 -0.018844
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.018759
ZBTB20 zinc finger and BTB domain containing 20 -0.0186964
PRRC2C proline-rich coiled-coil 2C -0.018664
PNISR PNN-interacting serine/arginine-rich protein -0.0183344
CENPE centromere protein E, 312kDa -0.0182768
MYO9A myosin IXA -0.0182027
RRBP1 ribosome binding protein 1 -0.0176608
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0175153
HDAC8 histone deacetylase 8 -0.0174386
SCLT1 sodium channel and clathrin linker 1 -0.0171989
TPT1 tumor protein, translationally-controlled 1 -0.0169643
RPS3 ribosomal protein S3 -0.0166934
MTSS1 metastasis suppressor 1 -0.0165655
TPM1 tropomyosin 1 (alpha) -0.0165377
RPLP2 ribosomal protein, large, P2 -0.0163413
RPL9 ribosomal protein L9 -0.0162224
ZMYND8 zinc finger, MYND-type containing 8 -0.0162049
NF1 neurofibromin 1 -0.0161951
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0161366
UBE3A ubiquitin protein ligase E3A -0.016109
IFI44L interferon-induced protein 44-like -0.0161026
ACTG1 actin gamma 1 -0.0160331
NPAS2 neuronal PAS domain protein 2 -0.0159205
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0158772
RAB22A RAB22A, member RAS oncogene family -0.0158717
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0157549
RPL4 ribosomal protein L4 -0.0157124
P4HB prolyl 4-hydroxylase, beta polypeptide -0.015498
SVIL supervillin -0.0154873
ANKRD12 ankyrin repeat domain 12 -0.0154035
RPL13A ribosomal protein L13a -0.0153379
PMP22 peripheral myelin protein 22 -0.0152395
RPS16 ribosomal protein S16 -0.0152187
SEC61G Sec61 gamma subunit -0.015215
RPL32 ribosomal protein L32 -0.0151656
RPL12 ribosomal protein L12 -0.0151407
EMP1 epithelial membrane protein 1 -0.0151282
IFI16 interferon, gamma-inducible protein 16 -0.0150736
SMC4 structural maintenance of chromosomes 4 -0.0150166
RPL11 ribosomal protein L11 -0.0148657
RPL36 ribosomal protein L36 -0.0146632
CBX3 chromobox homolog 3 -0.0146401
RPS5 ribosomal protein S5 -0.0146076
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.014508
RBM25 RNA binding motif protein 25 -0.014423
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0143539
SP100 SP100 nuclear antigen -0.0141533
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0140832
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0139567