| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.203662 |
| TENM1 | teneurin transmembrane protein 1 | 0.0944216 |
| CENPF | centromere protein F, 350/400kDa | 0.0866073 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0855482 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0798064 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0768996 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0712696 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0658109 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0623978 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0608579 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0606651 |
| PTMA | prothymosin, alpha | 0.0588353 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.057742 |
| FAT1 | FAT atypical cadherin 1 | 0.0553496 |
| MATR3 | matrin 3 | 0.0552587 |
| PCBP2 | poly(rC) binding protein 2 | 0.0550135 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0536341 |
| PEG10 | paternally expressed 10 | 0.0525202 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0524258 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0481669 |
| XPO1 | exportin 1 | 0.0442532 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0431325 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0431085 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0428716 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0420585 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0414628 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0410932 |
| NFIA | nuclear factor I/A | 0.0385534 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0384699 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0368339 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0362642 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0362264 |
| POTEF | POTE ankyrin domain family, member F | 0.0359774 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0359577 |
| JAM3 | junctional adhesion molecule 3 | 0.035242 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0345919 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0342102 |
| TPM3 | tropomyosin 3 | 0.0330964 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0323081 |
| MIS18BP1 | MIS18 binding protein 1 | 0.032148 |
| HDAC9 | histone deacetylase 9 | 0.0321277 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0314646 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0312937 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0305522 |
| MED13L | mediator complex subunit 13-like | 0.030344 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0301295 |
| NUP58 | nucleoporin 58 | 0.0299415 |
| TXNRD1 | thioredoxin reductase 1 | 0.0298506 |
| SMC1A | structural maintenance of chromosomes 1A | 0.029621 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0292623 |
| IRS2 | insulin receptor substrate 2 | 0.0290098 |
| VGF | VGF nerve growth factor inducible | 0.0287048 |
| FOXN3 | forkhead box N3 | 0.0285916 |
| TPX2 | TPX2, microtubule-associated | 0.0285452 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0283876 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0283524 |
| GPRIN3 | GPRIN family member 3 | 0.028025 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0273599 |
| RTN4 | reticulon 4 | 0.0271776 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0270121 |
| MKI67 | marker of proliferation Ki-67 | 0.0269009 |
| PDS5B | PDS5 cohesin associated factor B | 0.026896 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0268705 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.0267346 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0263365 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0261939 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0261004 |
| STK24 | serine/threonine kinase 24 | 0.0260847 |
| NCKAP1 | NCK-associated protein 1 | 0.0259317 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0254572 |
| CCNY | cyclin Y | 0.025136 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0251241 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0250514 |
| ECT2 | epithelial cell transforming 2 | 0.025029 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.024974 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0247875 |
| TUFT1 | tuftelin 1 | 0.0247805 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0247691 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0246571 |
| ANLN | anillin, actin binding protein | 0.0245904 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0243955 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0242836 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0241314 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.024125 |
| PKM | pyruvate kinase, muscle | 0.0240926 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0240756 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0240511 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0239485 |
| CALCA | calcitonin-related polypeptide alpha | 0.0239374 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0238555 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0238536 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0237117 |
| FOXC1 | forkhead box C1 | 0.0235671 |
| MTMR7 | myotubularin related protein 7 | 0.0235509 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0235238 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0235052 |
| CADM1 | cell adhesion molecule 1 | 0.0234221 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0232354 |
| RPS18 | ribosomal protein S18 | 0.0231147 |
| TUBB | tubulin, beta class I | 0.0225396 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.157423 |
| GPC6 | glypican 6 | -0.109023 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.100003 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.094327 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0794001 |
| ESRRG | estrogen-related receptor gamma | -0.0784538 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0694709 |
| KIF26B | kinesin family member 26B | -0.0633528 |
| GPC5 | glypican 5 | -0.0620853 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0617628 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0601963 |
| RORA | RAR-related orphan receptor A | -0.057572 |
| STC1 | stanniocalcin 1 | -0.0566084 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0523505 |
| NCKAP5 | NCK-associated protein 5 | -0.0522474 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.050903 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0508376 |
| PTCHD4 | patched domain containing 4 | -0.0492175 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.048555 |
| NELL1 | NEL-like 1 (chicken) | -0.0482066 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0480859 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0473767 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0464682 |
| SNTG1 | syntrophin, gamma 1 | -0.0453361 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0433066 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0432768 |
| SMYD3 | SET and MYND domain containing 3 | -0.0424003 |
| NDRG1 | N-myc downstream regulated 1 | -0.0415112 |
| ACTG1 | actin gamma 1 | -0.0412023 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.039436 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0387914 |
| EPHA6 | EPH receptor A6 | -0.0376717 |
| CNKSR3 | CNKSR family member 3 | -0.0372742 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0363956 |
| SCG2 | secretogranin II | -0.0359624 |
| MYT1L | myelin transcription factor 1-like | -0.0353159 |
| NBEA | neurobeachin | -0.0352522 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0338111 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0306621 |
| FGF14 | fibroblast growth factor 14 | -0.0302917 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0300207 |
| KLHL29 | kelch-like family member 29 | -0.0293291 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0292332 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0291401 |
| GOLGB1 | golgin B1 | -0.0289149 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0288337 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0288275 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0287222 |
| ASPH | aspartate beta-hydroxylase | -0.0279811 |
| SVIL | supervillin | -0.0270048 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0268858 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0266875 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0264822 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0260271 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0256627 |
| EFNA5 | ephrin-A5 | -0.0255543 |
| MT2A | metallothionein 2A | -0.0253771 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.025035 |
| HM13 | histocompatibility (minor) 13 | -0.024465 |
| SP100 | SP100 nuclear antigen | -0.024377 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0241797 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0238425 |
| CNTNAP5 | contactin associated protein-like 5 | -0.0238303 |
| DENND4A | DENN/MADD domain containing 4A | -0.0237861 |
| CDK13 | cyclin-dependent kinase 13 | -0.0235854 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0235816 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0231447 |
| EGR1 | early growth response 1 | -0.0230343 |
| SLC38A2 | solute carrier family 38, member 2 | -0.022518 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0225038 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0224161 |
| NAV1 | neuron navigator 1 | -0.0223718 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0220611 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0218293 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0214893 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.021267 |
| ZFHX3 | zinc finger homeobox 3 | -0.0212354 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0211154 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0210364 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0208022 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0207827 |
| SETX | senataxin | -0.0207542 |
| FN1 | fibronectin 1 | -0.0207454 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0206138 |
| ARFGEF3 | ARFGEF family member 3 | -0.0205818 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.020133 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.020102 |
| TRAPPC12 | trafficking protein particle complex 12 | -0.0197697 |
| HOMER1 | homer scaffolding protein 1 | -0.0196237 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.019538 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0191508 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0190834 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0189944 |
| BPTF | bromodomain PHD finger transcription factor | -0.0189 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0184091 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0182803 |
| ZNF804A | zinc finger protein 804A | -0.0182613 |
| TMEM165 | transmembrane protein 165 | -0.0180692 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0179366 |
| RIGI | RNA sensor RIG-I | -0.017802 |
