| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MSI2 | musashi RNA-binding protein 2 | 0.0990539 |
| FN1 | fibronectin 1 | 0.0940886 |
| NLGN1 | neuroligin 1 | 0.0829974 |
| PCBP2 | poly(rC) binding protein 2 | 0.0664553 |
| FMNL2 | formin-like 2 | 0.061572 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0597916 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0585758 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0584126 |
| SPAG9 | sperm associated antigen 9 | 0.0581492 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0566609 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0549207 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0537321 |
| MSN | moesin | 0.0533193 |
| PGK1 | phosphoglycerate kinase 1 | 0.0524792 |
| RPL3 | ribosomal protein L3 | 0.0521261 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0518914 |
| CADM1 | cell adhesion molecule 1 | 0.0518066 |
| SETD5 | SET domain containing 5 | 0.0509913 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0502718 |
| TPM3 | tropomyosin 3 | 0.0467163 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0459735 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.044207 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.043998 |
| BBX | bobby sox homolog (Drosophila) | 0.0428537 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0423563 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0413061 |
| HELZ | helicase with zinc finger | 0.0412089 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0402795 |
| NGLY1 | N-glycanase 1 | 0.0393782 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0379971 |
| PKM | pyruvate kinase, muscle | 0.0375885 |
| COPA | coatomer protein complex, subunit alpha | 0.0373852 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0369661 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0369267 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0367088 |
| MCL1 | myeloid cell leukemia 1 | 0.0362649 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0357776 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0351377 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0351376 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0350739 |
| FAM13A | family with sequence similarity 13, member A | 0.0349409 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0349281 |
| CCNY | cyclin Y | 0.0347898 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.034773 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0345257 |
| PHF21A | PHD finger protein 21A | 0.0343053 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0342905 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0332707 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0332122 |
| CTBP2 | C-terminal binding protein 2 | 0.0332061 |
| MEF2A | myocyte enhancer factor 2A | 0.0331019 |
| WDR45B | WD repeat domain 45B | 0.0328341 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0328309 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0325136 |
| SEPTIN9 | septin 9 | 0.0324182 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0323288 |
| QKI | QKI, KH domain containing, RNA binding | 0.0321415 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0319127 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0317968 |
| CA8 | carbonic anhydrase VIII | 0.0314265 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0311857 |
| HPCAL1 | hippocalcin-like 1 | 0.0307021 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.029727 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0296526 |
| RNF145 | ring finger protein 145 | 0.029527 |
| NAV2 | neuron navigator 2 | 0.0294824 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0294788 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0291276 |
| SMAD3 | SMAD family member 3 | 0.0290877 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0287787 |
| SSH1 | slingshot protein phosphatase 1 | 0.0285664 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0281477 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0277888 |
| MED13L | mediator complex subunit 13-like | 0.0277887 |
| OGA | O-GlcNAcase | 0.0277125 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0276996 |
| CD109 | CD109 molecule | 0.0274821 |
| ATP13A3 | ATPase type 13A3 | 0.027251 |
| FLNB | filamin B, beta | 0.0271716 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0270849 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0268526 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0265483 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0265475 |
| TFG | TRK-fused gene | 0.0265148 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 0.0264952 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0264786 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.0261313 |
| UBC | ubiquitin C | 0.0260919 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.025992 |
| AFDN | afadin, adherens junction formation factor | 0.0258254 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0258232 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0257665 |
| NUP58 | nucleoporin 58 | 0.0256598 |
| CLINT1 | clathrin interactor 1 | 0.0256134 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0255701 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0255242 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0254167 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0252918 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0252585 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0252147 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.110203 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0906152 |
| FMN1 | formin 1 | -0.0856307 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.083997 |
| VIM | vimentin | -0.0800193 |
| RPS3 | ribosomal protein S3 | -0.0691601 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0658242 |
| RPLP1 | ribosomal protein, large, P1 | -0.0638587 |
| TMSB10 | thymosin beta 10 | -0.0637339 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0502941 |
| RPL35A | ribosomal protein L35a | -0.0501875 |
| FTL | ferritin, light polypeptide | -0.0489715 |
| RPL23 | ribosomal protein L23 | -0.0428337 |
| FRMD4A | FERM domain containing 4A | -0.0424801 |
| ACTG1 | actin gamma 1 | -0.0407462 |
| CCND1 | cyclin D1 | -0.0401817 |
| RPS6 | ribosomal protein S6 | -0.0383469 |
| FRMD5 | FERM domain containing 5 | -0.0362234 |
| CD44 | CD44 molecule (Indian blood group) | -0.0357791 |
| CDK6 | cyclin-dependent kinase 6 | -0.0349005 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0341151 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0336217 |
| RPL11 | ribosomal protein L11 | -0.0336084 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0325917 |
| RPL37A | ribosomal protein L37a | -0.0302677 |
| RPL34 | ribosomal protein L34 | -0.0297694 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0287016 |
| RPS21 | ribosomal protein S21 | -0.0284432 |
| RACK1 | receptor for activated C kinase 1 | -0.0271762 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0263334 |
| RPLP2 | ribosomal protein, large, P2 | -0.0261842 |
| RPS19 | ribosomal protein S19 | -0.0254404 |
| RRBP1 | ribosome binding protein 1 | -0.024916 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0248949 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0237715 |
| PMEL | premelanosome protein | -0.023745 |
| RPS12 | ribosomal protein S12 | -0.0226449 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0223998 |
| RPS8 | ribosomal protein S8 | -0.0221635 |
| MACROD2 | MACRO domain containing 2 | -0.0219921 |
| RPL9 | ribosomal protein L9 | -0.0218173 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0215442 |
| RPL36 | ribosomal protein L36 | -0.0213361 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0205882 |
| RPS14 | ribosomal protein S14 | -0.0203954 |
| RPL38 | ribosomal protein L38 | -0.0202077 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0201543 |
| RPL5 | ribosomal protein L5 | -0.02009 |
| MT1X | metallothionein 1X | -0.0200827 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | -0.0195455 |
| S100A9 | S100 calcium binding protein A9 | -0.0193991 |
| RPL12 | ribosomal protein L12 | -0.0192598 |
| HMGB1 | high mobility group box 1 | -0.0190505 |
| RPS24 | ribosomal protein S24 | -0.0189398 |
| PCNX4 | pecanex 4 | -0.0187927 |
| RPS29 | ribosomal protein S29 | -0.018327 |
| RPL28 | ribosomal protein L28 | -0.0182062 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0180425 |
| KLHL13 | kelch-like family member 13 | -0.0179898 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0178534 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0178035 |
| RPS27A | ribosomal protein S27a | -0.0177283 |
| RPS13 | ribosomal protein S13 | -0.017703 |
| SAA2 | serum amyloid A2 | -0.0172426 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0169741 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.016964 |
| BPTF | bromodomain PHD finger transcription factor | -0.0169374 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | -0.0166176 |
| MELTF | melanotransferrin | -0.016568 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0165082 |
| RPS20 | ribosomal protein S20 | -0.0163102 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0160775 |
| RPL35 | ribosomal protein L35 | -0.015999 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0159168 |
| RASAL2 | RAS protein activator like 2 | -0.0156632 |
| RPL8 | ribosomal protein L8 | -0.0154872 |
| KLF6 | Kruppel-like factor 6 | -0.0154054 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0153448 |
| TBCA | tubulin folding cofactor A | -0.0149871 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0147585 |
| RPL27 | ribosomal protein L27 | -0.0147486 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0146696 |
| SNX24 | sorting nexin 24 | -0.0143611 |
| RPL19 | ribosomal protein L19 | -0.0143008 |
| CBX3 | chromobox homolog 3 | -0.0142023 |
| RPL26 | ribosomal protein L26 | -0.0141706 |
| RPS23 | ribosomal protein S23 | -0.014024 |
| RPS4X | ribosomal protein S4, X-linked | -0.0139784 |
| RPS16 | ribosomal protein S16 | -0.013965 |
| CLEC2D | C-type lectin domain family 2, member D | -0.0139561 |
| GSTO1 | glutathione S-transferase omega 1 | -0.013924 |
| TP63 | tumor protein p63 | -0.0137746 |
| CEP128 | centrosomal protein 128kDa | -0.0135556 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.0134783 |
| CHRM3 | cholinergic receptor, muscarinic 3 | -0.0134286 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0134061 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0132746 |
| ETV6 | ets variant 6 | -0.0132344 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.0131608 |
| RPS15 | ribosomal protein S15 | -0.0130411 |
