Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.126768
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.116917
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.101519
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0850063
ADAM10 ADAM metallopeptidase domain 10 0.0775137
KDM3A lysine (K)-specific demethylase 3A 0.0767704
NAMPT nicotinamide phosphoribosyltransferase 0.0751914
ZNF292 zinc finger protein 292 0.0727245
SSBP2 single-stranded DNA binding protein 2 0.0723735
RBM39 RNA binding motif protein 39 0.0711683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0680578
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0654305
ZFAND3 zinc finger, AN1-type domain 3 0.0644739
DSCAM Down syndrome cell adhesion molecule 0.0605625
EEF2 eukaryotic translation elongation factor 2 0.0596195
TJP1 tight junction protein 1 0.0583606
GOLGA4 golgin A4 0.0582152
EML4 echinoderm microtubule associated protein like 4 0.0581108
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0558979
KMT2E lysine (K)-specific methyltransferase 2E 0.0555064
FLNB filamin B, beta 0.0545005
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0544698
ELOVL5 ELOVL fatty acid elongase 5 0.0540148
NBAS neuroblastoma amplified sequence 0.0530846
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0529301
CDC73 cell division cycle 73 0.0526013
PGK1 phosphoglycerate kinase 1 0.0507863
CAMTA1 calmodulin binding transcription activator 1 0.0496416
NUP58 nucleoporin 58 0.047831
TXNIP thioredoxin interacting protein 0.0476702
QKI QKI, KH domain containing, RNA binding 0.0472586
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0471076
TFG TRK-fused gene 0.0469499
HDAC9 histone deacetylase 9 0.0458151
GARS1 glycyl-tRNA synthetase 1 0.0453899
CCNL1 cyclin L1 0.0441734
RNF145 ring finger protein 145 0.0437851
EVI5 ecotropic viral integration site 5 0.0433868
EIF4A2 eukaryotic translation initiation factor 4A2 0.0429163
EZR ezrin 0.0429126
ZEB1 zinc finger E-box binding homeobox 1 0.0418152
XPO1 exportin 1 0.041755
WAC WW domain containing adaptor with coiled-coil 0.041597
MSI2 musashi RNA-binding protein 2 0.0410475
RTN4 reticulon 4 0.0408942
PCBP2 poly(rC) binding protein 2 0.0408401
TXNRD1 thioredoxin reductase 1 0.0408357
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0407235
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0404123
PICALM phosphatidylinositol binding clathrin assembly protein 0.0399832
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0398549
ANKRD11 ankyrin repeat domain 11 0.0394407
ECT2 epithelial cell transforming 2 0.0392992
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0390023
NCKAP1 NCK-associated protein 1 0.0389797
PYGB phosphorylase, glycogen; brain 0.0386302
ADAM9 ADAM metallopeptidase domain 9 0.0382629
BRWD1 bromodomain and WD repeat domain containing 1 0.0378353
FNDC3B fibronectin type III domain containing 3B 0.0366668
APP amyloid beta (A4) precursor protein 0.0364411
PDGFC platelet derived growth factor C 0.0362817
SETD5 SET domain containing 5 0.0361379
GSK3B glycogen synthase kinase 3 beta 0.0353369
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0353125
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.034927
JMJD1C jumonji domain containing 1C 0.0345932
RPL3 ribosomal protein L3 0.03416
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0341216
USP3 ubiquitin specific peptidase 3 0.0340761
ZMYM2 zinc finger, MYM-type 2 0.0332455
VCL vinculin 0.0328447
BIRC6 baculoviral IAP repeat containing 6 0.0327246
KDM6A lysine (K)-specific demethylase 6A 0.0326251
PTK2 protein tyrosine kinase 2 0.0325434
UBA6 ubiquitin-like modifier activating enzyme 6 0.0324127
PUM2 pumilio RNA-binding family member 2 0.0319869
SMYD3 SET and MYND domain containing 3 0.0318515
LDHA lactate dehydrogenase A 0.0317093
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0316581
COG5 component of oligomeric golgi complex 5 0.0314425
CHD1 chromodomain helicase DNA binding protein 1 0.0314175
LPP LIM domain containing preferred translocation partner in lipoma 0.0313848
EXT1 exostosin glycosyltransferase 1 0.0313235
ANK2 ankyrin 2, neuronal 0.0311138
TMEM41B transmembrane protein 41B 0.0310281
KMT2C lysine (K)-specific methyltransferase 2C 0.0307684
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0305999
RLF rearranged L-myc fusion 0.0304334
HELZ helicase with zinc finger 0.0303931
NF1 neurofibromin 1 0.0303346
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0302683
TOP2B topoisomerase (DNA) II beta 180kDa 0.0301161
PARD3 par-3 family cell polarity regulator 0.029957
ELP2 elongator acetyltransferase complex subunit 2 0.0298649
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0297745
TNRC6B trinucleotide repeat containing 6B 0.0296491
MATR3 matrin 3 0.0295145
CASC3 cancer susceptibility candidate 3 0.0294896
FXR1 fragile X mental retardation, autosomal homolog 1 0.0293081
PTBP2 polypyrimidine tract binding protein 2 0.0284932

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.1162
RPS8 ribosomal protein S8 -0.0495161
RPLP1 ribosomal protein, large, P1 -0.0472177
BMP10 bone morphogenetic protein 10 -0.0439338
RPS6 ribosomal protein S6 -0.0434744
RPS19 ribosomal protein S19 -0.0421721
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0399664
RPL35A ribosomal protein L35a -0.0379589
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0373332
RPL37A ribosomal protein L37a -0.0364757
RPL23 ribosomal protein L23 -0.0363708
RPL26 ribosomal protein L26 -0.0356773
NAV2 neuron navigator 2 -0.0343722
MT2A metallothionein 2A -0.0336021
RPL31 ribosomal protein L31 -0.0324077
RPL34 ribosomal protein L34 -0.0320405
TPT1 tumor protein, translationally-controlled 1 -0.0316503
MKI67 marker of proliferation Ki-67 -0.0316198
TMSB10 thymosin beta 10 -0.0308095
RPL36 ribosomal protein L36 -0.0305937
RPL12 ribosomal protein L12 -0.0305563
RPS17 ribosomal protein S17 -0.0293249
FTL ferritin, light polypeptide -0.0291222
RPL9 ribosomal protein L9 -0.0289644
RPS12 ribosomal protein S12 -0.0286668
NBEA neurobeachin -0.0272072
RPS3 ribosomal protein S3 -0.0260908
GLI3 GLI family zinc finger 3 -0.0260473
SMC4 structural maintenance of chromosomes 4 -0.0256867
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0253319
CENPF centromere protein F, 350/400kDa -0.0230927
RPLP2 ribosomal protein, large, P2 -0.022962
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0225838
RPL18 ribosomal protein L18 -0.0224662
TUBB4B tubulin, beta 4B class IVb -0.0219475
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0216062
PFN1 profilin 1 -0.0214422
RPS27A ribosomal protein S27a -0.0208621
TBCA tubulin folding cofactor A -0.0207799
RPS27 ribosomal protein S27 -0.0202731
RPS21 ribosomal protein S21 -0.0199557
RPL11 ribosomal protein L11 -0.0199538
RPS29 ribosomal protein S29 -0.0195969
CENPE centromere protein E, 312kDa -0.0193689
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0193661
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0191136
RPL19 ribosomal protein L19 -0.0190382
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0188007
LOC102724023 ES1 protein homolog, mitochondrial -0.0183617
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0179965
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0179878
DIAPH3 diaphanous-related formin 3 -0.0177944
CUX1 cut-like homeobox 1 -0.0175753
RPS16 ribosomal protein S16 -0.017551
PDE7B phosphodiesterase 7B -0.0174245
S100A9 S100 calcium binding protein A9 -0.0170734
RPL37 ribosomal protein L37 -0.0170592
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0170031
RPS13 ribosomal protein S13 -0.0168734
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0168688
RACK1 receptor for activated C kinase 1 -0.0165246
RPL27A ribosomal protein L27a -0.0163392
PRDX2 peroxiredoxin 2 -0.0161766
HJURP Holliday junction recognition protein -0.015712
INTS6 integrator complex subunit 6 -0.0155858
EMP3 epithelial membrane protein 3 -0.0154648
RPLP0 ribosomal protein, large, P0 -0.0144058
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0141707
AEBP2 AE binding protein 2 -0.0141246
CEP112 centrosomal protein 112kDa -0.0140424
RPL27 ribosomal protein L27 -0.0139261
TPX2 TPX2, microtubule-associated -0.0138568
RPL35 ribosomal protein L35 -0.0137529
HSPB1 heat shock 27kDa protein 1 -0.0137494
S100A4 S100 calcium binding protein A4 -0.0137427
RPS14 ribosomal protein S14 -0.013702
FN1 fibronectin 1 -0.0134519
IFI16 interferon, gamma-inducible protein 16 -0.0133751
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0130287
SDK1 sidekick cell adhesion molecule 1 -0.0127298
TUBA1B tubulin, alpha 1b -0.0125895
IFITM3 interferon induced transmembrane protein 3 -0.0125466
NACA nascent polypeptide-associated complex alpha subunit -0.0125137
SCLT1 sodium channel and clathrin linker 1 -0.0125136
RFC3 replication factor C (activator 1) 3, 38kDa -0.0124928
ACTG1 actin gamma 1 -0.0124508
TPI1 triosephosphate isomerase 1 -0.012382
RPL5 ribosomal protein L5 -0.0123747
RPS10 ribosomal protein S10 -0.0123533
VIM vimentin -0.0122118
RPS24 ribosomal protein S24 -0.0119822
RPL8 ribosomal protein L8 -0.011945
RPL30 ribosomal protein L30 -0.0119147
PRUNE2 prune homolog 2 (Drosophila) -0.0113967
HMGB1 high mobility group box 1 -0.0113585
RPL13A ribosomal protein L13a -0.0113176
APLF aprataxin and PNKP like factor -0.0111584
FER1L6 fer-1-like family member 6 -0.0111523
RPS5 ribosomal protein S5 -0.0110842
PABPN1 poly(A) binding protein, nuclear 1 -0.0110435