| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.137505 |
| COL6A3 | collagen, type VI, alpha 3 | 0.123126 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0957154 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0907782 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0881513 |
| LOXL2 | lysyl oxidase-like 2 | 0.0793029 |
| ANLN | anillin, actin binding protein | 0.070042 |
| FAM13A | family with sequence similarity 13, member A | 0.0667301 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.062196 |
| COL5A1 | collagen, type V, alpha 1 | 0.0602793 |
| EFNA5 | ephrin-A5 | 0.0595728 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.058721 |
| B2M | beta-2-microglobulin | 0.0586348 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0579694 |
| SMAD3 | SMAD family member 3 | 0.0576773 |
| PCBP2 | poly(rC) binding protein 2 | 0.0570438 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0559378 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0555008 |
| STC1 | stanniocalcin 1 | 0.0549454 |
| ATP13A3 | ATPase type 13A3 | 0.053968 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0516728 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0495449 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0483446 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0480675 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0478217 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0456575 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0456053 |
| GSE1 | Gse1 coiled-coil protein | 0.0452328 |
| ENO1 | enolase 1, (alpha) | 0.0451233 |
| HLA-A | major histocompatibility complex, class I, A | 0.0442615 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0438606 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0433307 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0427416 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0402859 |
| MSN | moesin | 0.0396581 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0393057 |
| MYO10 | myosin X | 0.0387241 |
| CENPF | centromere protein F, 350/400kDa | 0.038525 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0377722 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0375042 |
| ANXA2 | annexin A2 | 0.037478 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0364787 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0364396 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0363847 |
| SMYD3 | SET and MYND domain containing 3 | 0.0363698 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0362956 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0359998 |
| SNX13 | sorting nexin 13 | 0.0350211 |
| CUL4B | cullin 4B | 0.0345178 |
| RPS3 | ribosomal protein S3 | 0.034165 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0335045 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.033491 |
| USP47 | ubiquitin specific peptidase 47 | 0.0333763 |
| NEK7 | NIMA-related kinase 7 | 0.0333686 |
| COPA | coatomer protein complex, subunit alpha | 0.0333519 |
| STK10 | serine/threonine kinase 10 | 0.0329142 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0328899 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0328876 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0324714 |
| ZNF395 | zinc finger protein 395 | 0.0323528 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0321197 |
| ARRDC3 | arrestin domain containing 3 | 0.0319775 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0318279 |
| PGM3 | phosphoglucomutase 3 | 0.0317883 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0315984 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0313538 |
| SET | SET nuclear proto-oncogene | 0.0311233 |
| TXNIP | thioredoxin interacting protein | 0.0308717 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0305309 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0304216 |
| COL4A1 | collagen, type IV, alpha 1 | 0.030169 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0299432 |
| PGK1 | phosphoglycerate kinase 1 | 0.0297244 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0295685 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0293892 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.029217 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0291329 |
| TPX2 | TPX2, microtubule-associated | 0.0289167 |
| SEPTIN9 | septin 9 | 0.0287746 |
| CORO1C | coronin, actin binding protein, 1C | 0.0286108 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0285703 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0285581 |
| LONP2 | lon peptidase 2, peroxisomal | 0.0285038 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0284159 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0283246 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0279584 |
| PTMA | prothymosin, alpha | 0.0278202 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0277509 |
| EGFR | epidermal growth factor receptor | 0.0274817 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0272066 |
| STK24 | serine/threonine kinase 24 | 0.0271762 |
| MED13L | mediator complex subunit 13-like | 0.0270423 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0269757 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0269289 |
| HELZ | helicase with zinc finger | 0.0265787 |
| YEATS2 | YEATS domain containing 2 | 0.0265088 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0264956 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.026309 |
| RBM15 | RNA binding motif protein 15 | 0.0258431 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0258371 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.242583 |
| TMSB10 | thymosin beta 10 | -0.144479 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0928274 |
| CALD1 | caldesmon 1 | -0.0644261 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0644082 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0637717 |
| RPS6 | ribosomal protein S6 | -0.0596641 |
| VIM | vimentin | -0.0596072 |
| ACTG1 | actin gamma 1 | -0.0563996 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0563702 |
| TNS3 | tensin 3 | -0.0489141 |
| RTN4 | reticulon 4 | -0.0474272 |
| NABP1 | nucleic acid binding protein 1 | -0.0472189 |
| CD44 | CD44 molecule (Indian blood group) | -0.0467732 |
| FUS | FUS RNA binding protein | -0.0458876 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0450305 |
| DST | dystonin | -0.0447998 |
| NRXN3 | neurexin 3 | -0.0446991 |
| HIP1 | huntingtin interacting protein 1 | -0.0445999 |
| FRMD6 | FERM domain containing 6 | -0.0416998 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0414041 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0408736 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0403797 |
| VEGFC | vascular endothelial growth factor C | -0.0398137 |
| PRKCA | protein kinase C, alpha | -0.0396995 |
| POTEF | POTE ankyrin domain family, member F | -0.0386623 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0384221 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0383064 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0379479 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0371624 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0370115 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0365913 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.036337 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0358762 |
| INTS6 | integrator complex subunit 6 | -0.0358109 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0354787 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0353445 |
| HDAC9 | histone deacetylase 9 | -0.0350922 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0349723 |
| TAOK1 | TAO kinase 1 | -0.034898 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0345014 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0342072 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0338095 |
| CDK6 | cyclin-dependent kinase 6 | -0.0337299 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0337116 |
| SPAG9 | sperm associated antigen 9 | -0.0335501 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0333204 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0333004 |
| MYLK | myosin light chain kinase | -0.0329143 |
| RASAL2 | RAS protein activator like 2 | -0.0326111 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0323219 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0322304 |
| ITGAV | integrin, alpha V | -0.032121 |
| ZNF292 | zinc finger protein 292 | -0.0318854 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0315322 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0314236 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.031103 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0310861 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0306518 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0305379 |
| TPM1 | tropomyosin 1 (alpha) | -0.0300829 |
| JAK1 | Janus kinase 1 | -0.0296962 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0296933 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0296036 |
| FBN1 | fibrillin 1 | -0.0293706 |
| PALLD | palladin, cytoskeletal associated protein | -0.029209 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0290664 |
| RPS12 | ribosomal protein S12 | -0.0289425 |
| ANXA1 | annexin A1 | -0.0288996 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0288562 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0284095 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0277418 |
| FAM3C | family with sequence similarity 3, member C | -0.0275298 |
| RPLP0 | ribosomal protein, large, P0 | -0.0270629 |
| RRBP1 | ribosome binding protein 1 | -0.0270378 |
| TGFB1 | transforming growth factor, beta 1 | -0.0269544 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0268163 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0267134 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0266703 |
| TRIM56 | tripartite motif containing 56 | -0.0265994 |
| TENM3 | teneurin transmembrane protein 3 | -0.0265346 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0263953 |
| THY1 | Thy-1 cell surface antigen | -0.0260305 |
| TPM4 | tropomyosin 4 | -0.0259282 |
| CCDC14 | coiled-coil domain containing 14 | -0.0258538 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0257965 |
| PDLIM5 | PDZ and LIM domain 5 | -0.025669 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0256652 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0255786 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0252031 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0251993 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0251984 |
| RAI14 | retinoic acid induced 14 | -0.0251264 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0246577 |
| EHD2 | EH-domain containing 2 | -0.0246518 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0246414 |
| RPL11 | ribosomal protein L11 | -0.0246175 |
| JPH2 | junctophilin 2 | -0.0242751 |
| SRPK2 | SRSF protein kinase 2 | -0.024106 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0238153 |
