Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.124898
NAMPT nicotinamide phosphoribosyltransferase 0.105166
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.105067
MYH9 myosin, heavy chain 9, non-muscle 0.0770521
CD109 CD109 molecule 0.0755967
FNDC3B fibronectin type III domain containing 3B 0.0721658
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.069726
HIPK2 homeodomain interacting protein kinase 2 0.0556251
RUNX2 runt-related transcription factor 2 0.0555857
EREG epiregulin 0.0499041
TMEM156 transmembrane protein 156 0.045292
SMAD3 SMAD family member 3 0.0420292
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.038282
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0374513
STC2 stanniocalcin 2 0.0371199
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0332072
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0311885
TXNRD1 thioredoxin reductase 1 0.0305505
HPCAL1 hippocalcin-like 1 0.0289163
AHR aryl hydrocarbon receptor 0.0288534
SOS1 son of sevenless homolog 1 (Drosophila) 0.0286073
MEF2A myocyte enhancer factor 2A 0.0282521
JARID2 jumonji, AT rich interactive domain 2 0.0272619
ARHGAP35 Rho GTPase activating protein 35 0.0264569
SOD2 superoxide dismutase 2, mitochondrial 0.0258787
NEK7 NIMA-related kinase 7 0.0258653
SSH1 slingshot protein phosphatase 1 0.0258058
APP amyloid beta (A4) precursor protein 0.0251751
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0247842
UGCG UDP-glucose ceramide glucosyltransferase 0.0243555
ATP11A ATPase, class VI, type 11A 0.0238602
MB21D2 Mab-21 domain containing 2 0.0237362
CADM1 cell adhesion molecule 1 0.0236505
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0234409
TXNIP thioredoxin interacting protein 0.0232604
CDC73 cell division cycle 73 0.0231059
RBM39 RNA binding motif protein 39 0.0230735
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.022945
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0227717
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0225735
DENND3 DENN/MADD domain containing 3 0.0225729
LPP LIM domain containing preferred translocation partner in lipoma 0.022301
USP12 ubiquitin specific peptidase 12 0.0222681
FTH1 ferritin, heavy polypeptide 1 0.022006
CCNL1 cyclin L1 0.0210062
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0204482
TRIO trio Rho guanine nucleotide exchange factor 0.0201578
AHRR aryl-hydrocarbon receptor repressor 0.0200856
HELZ helicase with zinc finger 0.0199349
MACF1 microtubule-actin crosslinking factor 1 0.0198435
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0198406
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.019714
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.019523
RYBP RING1 and YY1 binding protein 0.0193358
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0192687
RAD23B RAD23 homolog B (S. cerevisiae) 0.0190605
LRP5 low density lipoprotein receptor-related protein 5 0.019027
PTBP3 polypyrimidine tract binding protein 3 0.0189998
CCNJL cyclin J-like 0.0187589
SEC23A Sec23 homolog A (S. cerevisiae) 0.018749
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0185752
SSBP2 single-stranded DNA binding protein 2 0.0185072
BIRC3 baculoviral IAP repeat containing 3 0.018481
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0184712
FLNA filamin A, alpha 0.0183001
PCBP2 poly(rC) binding protein 2 0.0182519
ELL2 elongation factor, RNA polymerase II, 2 0.0180387
ADAR adenosine deaminase, RNA-specific 0.0178929
FAT1 FAT atypical cadherin 1 0.0177027
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0175968
SEPTIN9 septin 9 0.017438
ARRDC3 arrestin domain containing 3 0.0170678
RPS18 ribosomal protein S18 0.016882
IRAK3 interleukin-1 receptor-associated kinase 3 0.0166065
RPL3 ribosomal protein L3 0.0165448
GPC6 glypican 6 0.0164778
LMCD1 LIM and cysteine-rich domains 1 0.0164391
FAM13A family with sequence similarity 13, member A 0.0161363
NRP1 neuropilin 1 0.0161089
MARCHF6 membrane associated ring-CH-type finger 6 0.0160419
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0159621
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0159316
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0158425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0158329
ZMIZ1 zinc finger, MIZ-type containing 1 0.0157849
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0156249
ZNF292 zinc finger protein 292 0.0156045
FHIT fragile histidine triad 0.0154882
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0154437
PELO pelota homolog (Drosophila) 0.0154362
SPRED2 sprouty-related, EVH1 domain containing 2 0.015389
CAB39 calcium binding protein 39 0.015237
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0151054
RAB8B RAB8B, member RAS oncogene family 0.015006
UHMK1 U2AF homology motif (UHM) kinase 1 0.0149907
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0149352
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0148724
MYO1B myosin IB 0.0147952
CORO1C coronin, actin binding protein, 1C 0.0147864
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0147412

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216264
PTMA prothymosin, alpha -0.106512
TMSB10 thymosin beta 10 -0.0898632
VIM vimentin -0.0593357
HLA-B major histocompatibility complex, class I, B -0.0553813
FTL ferritin, light polypeptide -0.0519779
HMGA2 high mobility group AT-hook 2 -0.0513538
NDRG1 N-myc downstream regulated 1 -0.0501965
ASPH aspartate beta-hydroxylase -0.0501632
EFNA5 ephrin-A5 -0.0501184
GLIS3 GLIS family zinc finger 3 -0.0478031
RPS6 ribosomal protein S6 -0.0452675
TPT1 tumor protein, translationally-controlled 1 -0.0448287
NRG1 neuregulin 1 -0.0406489
ACTG1 actin gamma 1 -0.0394636
TMSB4X thymosin beta 4, X-linked -0.0385365
MT2A metallothionein 2A -0.0373211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0352352
TMEM165 transmembrane protein 165 -0.0348955
RPS19 ribosomal protein S19 -0.0345841
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0342317
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0324851
RPLP1 ribosomal protein, large, P1 -0.0324714
FN1 fibronectin 1 -0.0323044
IFI27 interferon, alpha-inducible protein 27 -0.0322481
RPL37A ribosomal protein L37a -0.0320558
LOC102724023 ES1 protein homolog, mitochondrial -0.031703
RPL35A ribosomal protein L35a -0.0310432
RPS3 ribosomal protein S3 -0.0301774
INTS6 integrator complex subunit 6 -0.0301151
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0296412
SOX4 SRY (sex determining region Y)-box 4 -0.0294899
AEBP2 AE binding protein 2 -0.0280233
RPL37 ribosomal protein L37 -0.0272384
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0267847
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0263186
B2M beta-2-microglobulin -0.0261879
RPL26 ribosomal protein L26 -0.0261289
AKAP9 A kinase (PRKA) anchor protein 9 -0.0258488
RPL9 ribosomal protein L9 -0.0258346
HLA-A major histocompatibility complex, class I, A -0.0251978
RPL31 ribosomal protein L31 -0.0247689
RPL11 ribosomal protein L11 -0.0245879
RPL34 ribosomal protein L34 -0.0243995
RPS27A ribosomal protein S27a -0.0233893
EIF5B eukaryotic translation initiation factor 5B -0.0233034
RPL23 ribosomal protein L23 -0.0225988
LOX lysyl oxidase -0.0225693
RPL8 ribosomal protein L8 -0.0225014
S100A9 S100 calcium binding protein A9 -0.0224295
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0220861
SLC38A2 solute carrier family 38, member 2 -0.0219729
RPS16 ribosomal protein S16 -0.0218605
LIMCH1 LIM and calponin homology domains 1 -0.0216885
SEC31A SEC31 homolog A (S. cerevisiae) -0.0216458
RPL12 ribosomal protein L12 -0.0216407
MRPS6 mitochondrial ribosomal protein S6 -0.02142
GCC2 GRIP and coiled-coil domain containing 2 -0.021337
RBM25 RNA binding motif protein 25 -0.0209489
RPS21 ribosomal protein S21 -0.0207934
RPLP2 ribosomal protein, large, P2 -0.0203338
DPYD dihydropyrimidine dehydrogenase -0.0202968
S100A6 S100 calcium binding protein A6 -0.0202491
RPS8 ribosomal protein S8 -0.0201668
RASAL2 RAS protein activator like 2 -0.0201101
RPS27 ribosomal protein S27 -0.0200613
RPS5 ribosomal protein S5 -0.0200529
TTC3 tetratricopeptide repeat domain 3 -0.0199945
RPS24 ribosomal protein S24 -0.0199233
RACK1 receptor for activated C kinase 1 -0.0198084
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0196082
RPS25 ribosomal protein S25 -0.0195645
BPTF bromodomain PHD finger transcription factor -0.0193728
RPL36 ribosomal protein L36 -0.0192941
RPS29 ribosomal protein S29 -0.0191934
TM4SF1 transmembrane 4 L six family member 1 -0.0189411
WSB1 WD repeat and SOCS box containing 1 -0.0188566
TBCA tubulin folding cofactor A -0.0187363
CDK13 cyclin-dependent kinase 13 -0.0187223
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0186317
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0185322
VDAC1 voltage-dependent anion channel 1 -0.0181944
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0180684
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0180256
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0179772
RPS12 ribosomal protein S12 -0.0178319
MTDH metadherin -0.0177454
ETV1 ets variant 1 -0.0177309
SPDYA speedy/RINGO cell cycle regulator family member A -0.017681
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0175242
LRRC23 leucine rich repeat containing 23 -0.0172831
EGR1 early growth response 1 -0.0172535
TAS2R14 taste receptor, type 2, member 14 -0.0170768
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0170142
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0170138
RPL18 ribosomal protein L18 -0.0169696
RAI14 retinoic acid induced 14 -0.0168649
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0166313
RPL28 ribosomal protein L28 -0.0165088
RANBP17 RAN binding protein 17 -0.0165081