Dapagliflozin ((2S)-1,2-propanediol, hydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dapagliflozin ((2S)-1,2-propanediol, hydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dapagliflozin ((2S)-1,2-propanediol, hydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.144008
MYH9 myosin, heavy chain 9, non-muscle 0.113316
FNDC3B fibronectin type III domain containing 3B 0.0910913
INHBA inhibin, beta A 0.0881611
JARID2 jumonji, AT rich interactive domain 2 0.0874651
SOD2 superoxide dismutase 2, mitochondrial 0.0815838
LOXL2 lysyl oxidase-like 2 0.0734523
ATP13A3 ATPase type 13A3 0.0715797
FAM13A family with sequence similarity 13, member A 0.0670558
FN1 fibronectin 1 0.066568
HIPK2 homeodomain interacting protein kinase 2 0.0631651
SMAD3 SMAD family member 3 0.058879
ELL2 elongation factor, RNA polymerase II, 2 0.0478746
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0465844
MEIS1 Meis homeobox 1 0.0458532
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0455396
COL4A2 collagen, type IV, alpha 2 0.0447479
PDE4D phosphodiesterase 4D, cAMP-specific 0.0442847
COL4A1 collagen, type IV, alpha 1 0.0376335
PCBP2 poly(rC) binding protein 2 0.0365005
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0354749
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0349242
COL1A2 collagen, type I, alpha 2 0.0347021
APP amyloid beta (A4) precursor protein 0.0329004
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0328344
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0325845
PDE8A phosphodiesterase 8A 0.0319295
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0317944
WNT5A wingless-type MMTV integration site family, member 5A 0.0303041
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0301558
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.030058
GREM1 gremlin 1, DAN family BMP antagonist 0.0290831
APAF1 apoptotic peptidase activating factor 1 0.0277841
COL5A2 collagen, type V, alpha 2 0.0269535
SNX9 sorting nexin 9 0.0266206
RUNX1 runt-related transcription factor 1 0.0264569
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0263076
TNPO1 transportin 1 0.0262275
EXT1 exostosin glycosyltransferase 1 0.0258752
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256224
NBAS neuroblastoma amplified sequence 0.0252943
TRIO trio Rho guanine nucleotide exchange factor 0.0247883
CALD1 caldesmon 1 0.0245254
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0240585
FAT1 FAT atypical cadherin 1 0.0236216
CHD1 chromodomain helicase DNA binding protein 1 0.0231938
SEPTIN9 septin 9 0.0227945
HDLBP high density lipoprotein binding protein 0.02269
NFE2L2 nuclear factor, erythroid 2-like 2 0.0221006
CAMTA1 calmodulin binding transcription activator 1 0.0219349
NAV1 neuron navigator 1 0.0216036
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0214756
SERINC1 serine incorporator 1 0.0212144
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.020898
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0208571
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0207923
SETD5 SET domain containing 5 0.0206435
CLTC clathrin, heavy chain (Hc) 0.0205428
NGLY1 N-glycanase 1 0.0203786
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0203319
COL3A1 collagen, type III, alpha 1 0.0201445
TRAM2 translocation associated membrane protein 2 0.0199536
AHNAK AHNAK nucleoprotein 0.0199262
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0199232
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.01972
SOCS5 suppressor of cytokine signaling 5 0.0195958
SAMD4A sterile alpha motif domain containing 4A 0.0195822
PDE4B phosphodiesterase 4B, cAMP-specific 0.0194025
PLPP3 phospholipid phosphatase 3 0.019159
FBN1 fibrillin 1 0.0190979
NAMPT nicotinamide phosphoribosyltransferase 0.0188739
EPAS1 endothelial PAS domain protein 1 0.0184167
CORO1C coronin, actin binding protein, 1C 0.0183548
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0183262
RPL3 ribosomal protein L3 0.0181862
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0179956
COG6 component of oligomeric golgi complex 6 0.0178911
PCBP3 poly(rC) binding protein 3 0.0177799
CALU calumenin 0.0177339
SMOX spermine oxidase 0.0177338
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0176331
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.017584
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0174286
ZFC3H1 zinc finger, C3H1-type containing 0.0173115
ANKIB1 ankyrin repeat and IBR domain containing 1 0.017255
RPS18 ribosomal protein S18 0.0172474
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0171832
PER1 period circadian clock 1 0.0171526
COL1A1 collagen, type I, alpha 1 0.0166867
SPAG9 sperm associated antigen 9 0.0165291
GPATCH2L G patch domain containing 2-like 0.016382
KDM3A lysine (K)-specific demethylase 3A 0.0162911
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0157645
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0157371
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0154238
BBX bobby sox homolog (Drosophila) 0.0152232
MYOF myoferlin 0.0151688
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0150691
ZNF292 zinc finger protein 292 0.0147376
LOX lysyl oxidase 0.0146107

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.223884
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175132
TMSB10 thymosin beta 10 -0.119961
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0878785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0808472
HMGA2 high mobility group AT-hook 2 -0.074782
AKAP12 A kinase (PRKA) anchor protein 12 -0.0699438
HLA-B major histocompatibility complex, class I, B -0.0667318
RPS6 ribosomal protein S6 -0.0660004
NDRG1 N-myc downstream regulated 1 -0.0637992
STC1 stanniocalcin 1 -0.0633292
FTL ferritin, light polypeptide -0.0514184
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0464103
RPLP1 ribosomal protein, large, P1 -0.0437288
TPT1 tumor protein, translationally-controlled 1 -0.0402372
RPS8 ribosomal protein S8 -0.0388622
ACTG1 actin gamma 1 -0.0381192
MT2A metallothionein 2A -0.0361102
OXR1 oxidation resistance 1 -0.0346378
RPL35A ribosomal protein L35a -0.0345591
B2M beta-2-microglobulin -0.0340462
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0340218
RPS19 ribosomal protein S19 -0.0332757
RPL12 ribosomal protein L12 -0.0324681
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0323346
EIF1 eukaryotic translation initiation factor 1 -0.0322478
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031138
RPL37A ribosomal protein L37a -0.0310934
TMEM165 transmembrane protein 165 -0.0301774
RPS12 ribosomal protein S12 -0.0296559
RPL34 ribosomal protein L34 -0.0296005
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0291504
EMP1 epithelial membrane protein 1 -0.0290043
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0281929
PTMA prothymosin, alpha -0.0272099
RPL26 ribosomal protein L26 -0.0270634
RPL23 ribosomal protein L23 -0.026738
HILPDA hypoxia inducible lipid droplet-associated -0.0267017
PFN1 profilin 1 -0.0263917
RPLP2 ribosomal protein, large, P2 -0.0257664
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.025583
RPL28 ribosomal protein L28 -0.025116
S100A9 S100 calcium binding protein A9 -0.0245743
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.024357
RPS14 ribosomal protein S14 -0.0233715
SLIT2 slit homolog 2 (Drosophila) -0.0232893
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0231212
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0229313
KTN1 kinectin 1 (kinesin receptor) -0.0225185
RPL7A ribosomal protein L7a -0.0223689
RPL5 ribosomal protein L5 -0.0223054
RPL11 ribosomal protein L11 -0.0222451
RPL31 ribosomal protein L31 -0.0220302
AKAP9 A kinase (PRKA) anchor protein 9 -0.0214879
TMSB4X thymosin beta 4, X-linked -0.0213779
PDIA3 protein disulfide isomerase family A, member 3 -0.0212889
RPL9 ribosomal protein L9 -0.0205794
PRRC2C proline-rich coiled-coil 2C -0.0204671
TIMP2 TIMP metallopeptidase inhibitor 2 -0.020018
CLMP CXADR-like membrane protein -0.0196762
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0196385
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0194966
RPS16 ribosomal protein S16 -0.0191459
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0190086
NPTX1 neuronal pentraxin I -0.0190074
WSB1 WD repeat and SOCS box containing 1 -0.0186835
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0184914
LOC112694756 uncharaterized LOC112694756 -0.0184658
TFPI2 tissue factor pathway inhibitor 2 -0.0182985
PKM pyruvate kinase, muscle -0.0179622
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0178896
RPS3 ribosomal protein S3 -0.0177378
EGR1 early growth response 1 -0.0177254
RPS17 ribosomal protein S17 -0.0176806
IGF2 insulin-like growth factor 2 -0.0175816
RPS27A ribosomal protein S27a -0.0175516
POTEF POTE ankyrin domain family, member F -0.0175379
TPM4 tropomyosin 4 -0.0173271
MYADM myeloid-associated differentiation marker -0.017135
RPL30 ribosomal protein L30 -0.0169355
RPL27 ribosomal protein L27 -0.0168824
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0163472
TGFBI transforming growth factor, beta-induced, 68kDa -0.0162792
RPS13 ribosomal protein S13 -0.0162509
ASTN2 astrotactin 2 -0.015894
ALCAM activated leukocyte cell adhesion molecule -0.0156854
DLC1 DLC1 Rho GTPase activating protein -0.0152555
RPL10A ribosomal protein L10a -0.0152089
RPL35 ribosomal protein L35 -0.0151681
SAMD3 sterile alpha motif domain containing 3 -0.015111
KIAA1549L KIAA1549-like -0.0150878
BTG1 B-cell translocation gene 1, anti-proliferative -0.0150503
MAML3 mastermind-like 3 (Drosophila) -0.0149062
TCEAL9 transcription elongation factor A like 9 -0.0147294
RPS29 ribosomal protein S29 -0.0146938
CA12 carbonic anhydrase XII -0.0146671
RPS27 ribosomal protein S27 -0.0146402
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0144009
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0142785
RPL27A ribosomal protein L27a -0.0141811