Dapagliflozin Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9887712
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Genes

196 proteins with high or low expression in Dapagliflozin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 1.94
ALPK3 alpha-kinase 3 1.51
TTLL4 tubulin tyrosine ligase-like family member 4 1.45
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 1.12
UBN1 ubinuclein 1 0.92
CCDC82 coiled-coil domain containing 82 0.88
LGALSL lectin, galactoside-binding-like 0.8
GPR161 G protein-coupled receptor 161 0.74
NEK4 NIMA-related kinase 4 0.71
KMT2B lysine (K)-specific methyltransferase 2B 0.7
TPM4 tropomyosin 4 0.68
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.63
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.63
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.61
FBXO33 F-box protein 33 0.59
CIR1 corepressor interacting with RBPJ, 1 0.59
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.57
ATF7 activating transcription factor 7 0.56
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.54
ANKRD13B ankyrin repeat domain 13B 0.54
CCDC18 coiled-coil domain containing 18 0.53
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.52
TEN1 TEN1 CST complex subunit 0.5
TM7SF2 transmembrane 7 superfamily member 2 0.5
NDRG1 N-myc downstream regulated 1 0.49
STMN2 stathmin 2 0.48
TPM1 tropomyosin 1 (alpha) 0.47
TPM3 tropomyosin 3 0.46
ATP5PF ATP synthase peripheral stalk subunit F6 0.45
DPY30 dpy-30 homolog (C. elegans) 0.44
UBTD2 ubiquitin domain containing 2 0.44
ADCY10 adenylate cyclase 10 (soluble) 0.44
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.44
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.44
PARP9 poly (ADP-ribose) polymerase family, member 9 0.44
GON7 GON7 subunit of KEOPS complex 0.42
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.42
ETNK2 ethanolamine kinase 2 0.42
ZFYVE1 zinc finger, FYVE domain containing 1 0.41
DBF4 DBF4 zinc finger 0.41
MCRIP1 MAPK regulated corepressor interacting protein 1 0.4
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.4
PHC1 polyhomeotic homolog 1 (Drosophila) 0.4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.4
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.4
KDM5C lysine (K)-specific demethylase 5C 0.4
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 0.39
NUCB2 nucleobindin 2 0.39
GALT galactose-1-phosphate uridylyltransferase 0.39
ALDOC aldolase C, fructose-bisphosphate 0.39
FDX1 ferredoxin 1 0.38
KDM5B lysine (K)-specific demethylase 5B 0.38
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.38
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.38
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 0.38
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.37
SETD6 SET domain containing 6 0.37
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.36
USP48 ubiquitin specific peptidase 48 0.36
STMN1 stathmin 1 0.36
KDM3A lysine (K)-specific demethylase 3A 0.36
UBAP1 ubiquitin associated protein 1 0.36
N4BP2L2 NEDD4 binding protein 2-like 2 0.36
CCDC88C coiled-coil domain containing 88C 0.36
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.35
DCLRE1A DNA cross-link repair 1A 0.35
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.35
KDM4B lysine (K)-specific demethylase 4B 0.35
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.34
PAQR4 progestin and adipoQ receptor family member IV 0.34
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.34
ZNF428 zinc finger protein 428 0.34
WNT16 wingless-type MMTV integration site family, member 16 0.33
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.33
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.33
C20ORF194 chromosome 20 open reading frame 194 0.32
YDJC YdjC homolog (bacterial) 0.32
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 0.32
DIPK1A divergent protein kinase domain 1A 0.32
TMSB10 thymosin beta 10 0.32
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.32
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.31
MARCHF7 membrane associated ring-CH-type finger 7 0.31
CEP89 centrosomal protein 89kDa 0.31
PSAP prosaposin 0.3
ERI1 exoribonuclease 1 0.3
ZCCHC24 zinc finger, CCHC domain containing 24 0.3
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.3
TMEM222 transmembrane protein 222 0.3
TPM2 tropomyosin 2 (beta) 0.3
MTPN myotrophin 0.3
MPHOSPH9 M-phase phosphoprotein 9 0.29
BTG3 BTG family, member 3 0.29
CBY1 chibby homolog 1 (Drosophila) 0.29
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.29
IGFBP3 insulin-like growth factor binding protein 3 0.29

low expression

Symbol Name Standardized Value
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -1.02
MTSS2 MTSS I-BAR domain containing 2 -0.79
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -0.76
NDFIP2 Nedd4 family interacting protein 2 -0.69
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.63
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.62
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.54
CCDC127 coiled-coil domain containing 127 -0.5
UNC80 unc-80 homolog (C. elegans) -0.5
SYK spleen tyrosine kinase -0.49
SUCO SUN domain containing ossification factor -0.49
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -0.48
KLK6 kallikrein-related peptidase 6 -0.48
ZNF7 zinc finger protein 7 -0.46
SVBP small vasohibin binding protein -0.46
ADARB1 adenosine deaminase, RNA-specific, B1 -0.46
SETD5 SET domain containing 5 -0.46
BAK1 BCL2-antagonist/killer 1 -0.45
PCGF5 polycomb group ring finger 5 -0.44
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.44
ABHD13 abhydrolase domain containing 13 -0.42
CCNQ cyclin Q -0.4
RIN3 Ras and Rab interactor 3 -0.39
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -0.39
MYO1G myosin IG -0.38
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -0.38
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 -0.38
EPHB3 EPH receptor B3 -0.37
COL1A2 collagen, type I, alpha 2 -0.36
FBXO45 F-box protein 45 -0.36
ZNF691 zinc finger protein 691 -0.36
TUBAL3 tubulin, alpha-like 3 -0.35
TMEM147 transmembrane protein 147 -0.35
BICRA BRD4 interacting chromatin remodeling complex associated protein -0.35
TCP11L1 t-complex 11, testis-specific-like 1 -0.35
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -0.35
FAM199X family with sequence similarity 199, X-linked -0.35
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -0.35
ATP9B ATPase, class II, type 9B -0.35
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.35
COPS4 COP9 signalosome subunit 4 -0.34
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -0.34
TACSTD2 tumor-associated calcium signal transducer 2 -0.34
MYO3A myosin IIIA -0.33
NRIP1 nuclear receptor interacting protein 1 -0.33
TMEM263 transmembrane protein 263 -0.33
TENT5A terminal nucleotidyltransferase 5A -0.33
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.33
PTPRD protein tyrosine phosphatase, receptor type, D -0.33
IFI30 interferon, gamma-inducible protein 30 -0.33
GGPS1 geranylgeranyl diphosphate synthase 1 -0.33
SOCS2 suppressor of cytokine signaling 2 -0.33
IFRD1 interferon-related developmental regulator 1 -0.32
MYORG myogenesis regulating glycosidase (putative) -0.32
DGKH diacylglycerol kinase, eta -0.32
ARHGAP22 Rho GTPase activating protein 22 -0.31
CLK4 CDC-like kinase 4 -0.31
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -0.3
C16ORF72 chromosome 16 open reading frame 72 -0.3
RHOB ras homolog family member B -0.3
MARCHF6 membrane associated ring-CH-type finger 6 -0.3
PET117 PET117 homolog (S. cerevisiae) -0.29
CCNE1 cyclin E1 -0.29
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -0.29
EXTL3 exostosin-like glycosyltransferase 3 -0.28
ECI1 enoyl-CoA delta isomerase 1 -0.28
CST6 cystatin E/M -0.27
RFXAP regulatory factor X-associated protein -0.27
ELL3 elongation factor RNA polymerase II-like 3 -0.27
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -0.27
EIF3K eukaryotic translation initiation factor 3, subunit K -0.27
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.27
LIN7A lin-7 homolog A (C. elegans) -0.26
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.26
KAZN kazrin, periplakin interacting protein -0.26
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.26
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.26
CCAR2 cell cycle and apoptosis regulator 2 -0.26
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -0.26
FBRSL1 fibrosin-like 1 -0.26
DUSP5 dual specificity phosphatase 5 -0.25
PWWP3A PWWP domain containing 3A, DNA repair factor -0.25
EEF1AKMT2 EEF1A lysine methyltransferase 2 -0.25
SYTL3 synaptotagmin-like 3 -0.25
POTEE POTE ankyrin domain family, member E -0.25
NAT14 N-acetyltransferase 14 (GCN5-related, putative) -0.25
SYNGR2 synaptogyrin 2 -0.25
CENPJ centromere protein J -0.25
CCNE2 cyclin E2 -0.25
HAUS4 HAUS augmin-like complex, subunit 4 -0.25
PLEC plectin -0.25
ASNSD1 asparagine synthetase domain containing 1 -0.25
RMI2 RecQ mediated genome instability 2 -0.25
TMEM168 transmembrane protein 168 -0.25
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type -0.24
MPND MPN domain containing -0.24
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -0.24
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -0.24
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -0.24
F3 coagulation factor III (thromboplastin, tissue factor) -0.24