| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dapagliflozin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dapagliflozin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0841369 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0800664 |
| FBN1 | fibrillin 1 | 0.0778747 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0705038 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0672573 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0581326 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0548975 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0515739 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0431312 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0406249 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.039002 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0389447 |
| SEPTIN9 | septin 9 | 0.0363792 |
| LOX | lysyl oxidase | 0.0353586 |
| COPA | coatomer protein complex, subunit alpha | 0.0346427 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0337185 |
| ATP13A3 | ATPase type 13A3 | 0.0333193 |
| CD109 | CD109 molecule | 0.0320905 |
| DST | dystonin | 0.0310677 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.030393 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0303782 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0289209 |
| APP | amyloid beta (A4) precursor protein | 0.0288497 |
| LOXL2 | lysyl oxidase-like 2 | 0.0270098 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0269283 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0269072 |
| UBC | ubiquitin C | 0.0267974 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.026069 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0252187 |
| FLNA | filamin A, alpha | 0.0250177 |
| PLEC | plectin | 0.0247522 |
| HIP1 | huntingtin interacting protein 1 | 0.0245048 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.024385 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0241377 |
| AUTS2 | autism susceptibility candidate 2 | 0.0238114 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0236094 |
| GPC6 | glypican 6 | 0.0235716 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0235672 |
| FLNB | filamin B, beta | 0.0234376 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0233137 |
| HELZ | helicase with zinc finger | 0.0232816 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.022844 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0224756 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0220738 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0219097 |
| SUCO | SUN domain containing ossification factor | 0.021421 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0213493 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0213038 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.021044 |
| C1D | C1D nuclear receptor corepressor | 0.02089 |
| GOLGA4 | golgin A4 | 0.0207533 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0206668 |
| MMP12 | matrix metallopeptidase 12 | 0.0200668 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0198998 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0197926 |
| SBF2 | SET binding factor 2 | 0.0197413 |
| OGA | O-GlcNAcase | 0.0197065 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0195388 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0194169 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0192473 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0192208 |
| DENND5A | DENN/MADD domain containing 5A | 0.0190535 |
| NDRG1 | N-myc downstream regulated 1 | 0.0188523 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0187742 |
| NOTCH2 | notch 2 | 0.0184521 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0184519 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0183171 |
| SFTPA2 | surfactant protein A2 | 0.0181561 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0181326 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0180633 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0178034 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0177953 |
| ERBIN | erbb2 interacting protein | 0.0174872 |
| SETD5 | SET domain containing 5 | 0.0173857 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0173172 |
| MAP4 | microtubule-associated protein 4 | 0.0171058 |
| USP12 | ubiquitin specific peptidase 12 | 0.0169671 |
| NAV2 | neuron navigator 2 | 0.0169316 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.016891 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0168511 |
| INSIG2 | insulin induced gene 2 | 0.016669 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0164921 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0164604 |
| FMNL2 | formin-like 2 | 0.0163825 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0163377 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0162198 |
| PCGF5 | polycomb group ring finger 5 | 0.0161843 |
| FNIP1 | folliculin interacting protein 1 | 0.0160346 |
| MSN | moesin | 0.0158873 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0158452 |
| NCKAP1 | NCK-associated protein 1 | 0.0158353 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0157361 |
| ATP11B | ATPase, class VI, type 11B | 0.0157232 |
| NGLY1 | N-glycanase 1 | 0.0153607 |
| CTBP2 | C-terminal binding protein 2 | 0.0152736 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0152619 |
| MB21D2 | Mab-21 domain containing 2 | 0.0152362 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0152154 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0152142 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0151704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.241747 |
| VIM | vimentin | -0.218458 |
| MT2A | metallothionein 2A | -0.18208 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0990544 |
| S100A10 | S100 calcium binding protein A10 | -0.0911935 |
| HLA-B | major histocompatibility complex, class I, B | -0.084447 |
| FN1 | fibronectin 1 | -0.0735651 |
| PTMA | prothymosin, alpha | -0.0626449 |
| CSTB | cystatin B (stefin B) | -0.0604189 |
| S100A6 | S100 calcium binding protein A6 | -0.0586346 |
| LMNA | lamin A/C | -0.0552278 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0552062 |
| B2M | beta-2-microglobulin | -0.0543043 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0510955 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0504618 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0499487 |
| PODXL | podocalyxin-like | -0.0495211 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.049292 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0472407 |
| MT1X | metallothionein 1X | -0.0456032 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0455474 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0453049 |
| PRSS23 | protease, serine, 23 | -0.0447239 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0442657 |
| CAVIN1 | caveolae associated protein 1 | -0.0439505 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0438995 |
| SUCNR1 | succinate receptor 1 | -0.0424182 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0416019 |
| CD44 | CD44 molecule (Indian blood group) | -0.0405118 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0381503 |
| RPL23 | ribosomal protein L23 | -0.03759 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0373463 |
| S100A4 | S100 calcium binding protein A4 | -0.0353641 |
| PLAT | plasminogen activator, tissue | -0.0347624 |
| RPL35A | ribosomal protein L35a | -0.0347299 |
| MX2 | MX dynamin-like GTPase 2 | -0.0341634 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334633 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.033236 |
| RPS19 | ribosomal protein S19 | -0.0329668 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0320063 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0306267 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0304942 |
| RPLP1 | ribosomal protein, large, P1 | -0.0304057 |
| S100A11 | S100 calcium binding protein A11 | -0.0303788 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.030109 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0299791 |
| RPL36 | ribosomal protein L36 | -0.0290869 |
| CDH13 | cadherin 13 | -0.0290854 |
| RRBP1 | ribosome binding protein 1 | -0.0288056 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.028116 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0273637 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0269738 |
| RPS8 | ribosomal protein S8 | -0.026484 |
| SEC61G | Sec61 gamma subunit | -0.0261058 |
| RPL26 | ribosomal protein L26 | -0.0260796 |
| TMSB4X | thymosin beta 4, X-linked | -0.0259997 |
| TAGLN2 | transgelin 2 | -0.0257829 |
| RPS6 | ribosomal protein S6 | -0.0257221 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0252492 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0249835 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0246064 |
| DCLK2 | doublecortin-like kinase 2 | -0.0245089 |
| RPL28 | ribosomal protein L28 | -0.024446 |
| RPL12 | ribosomal protein L12 | -0.0243025 |
| ASPH | aspartate beta-hydroxylase | -0.0239482 |
| LRRC17 | leucine rich repeat containing 17 | -0.0231127 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0230408 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0227409 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0226631 |
| RPS21 | ribosomal protein S21 | -0.0226533 |
| RNF213 | ring finger protein 213 | -0.022432 |
| HLA-C | major histocompatibility complex, class I, C | -0.0220237 |
| PLXNA2 | plexin A2 | -0.0220233 |
| MYADM | myeloid-associated differentiation marker | -0.0220118 |
| RPS15 | ribosomal protein S15 | -0.0218774 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0216487 |
| RPL35 | ribosomal protein L35 | -0.021601 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0215648 |
| RPS24 | ribosomal protein S24 | -0.0211944 |
| RPL32 | ribosomal protein L32 | -0.0210957 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0203616 |
| S100A9 | S100 calcium binding protein A9 | -0.0202986 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0202786 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0202672 |
| RPS3 | ribosomal protein S3 | -0.0202234 |
| PFN1 | profilin 1 | -0.0201318 |
| RPL37A | ribosomal protein L37a | -0.0198443 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0197271 |
| ACTG1 | actin gamma 1 | -0.0197229 |
| SEPTIN7 | septin 7 | -0.0197003 |
| RPL34 | ribosomal protein L34 | -0.0196819 |
| TPM4 | tropomyosin 4 | -0.0192506 |
| RIGI | RNA sensor RIG-I | -0.0191698 |
| SP100 | SP100 nuclear antigen | -0.0190699 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0190477 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190292 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0189934 |
| FTL | ferritin, light polypeptide | -0.01897 |
| RPS11 | ribosomal protein S11 | -0.0186683 |
| RPL38 | ribosomal protein L38 | -0.0186594 |
